ENSG00000100599


Homo sapiens

Features
Gene ID: ENSG00000100599
  
Biological name :RIN3
  
Synonyms : Q8TB24 / Ras and Rab interactor 3 / RIN3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q32.12
Gene start: 92513774
Gene end: 92688994
  
Corresponding Affymetrix probe sets: 1562005_at (Human Genome U133 Plus 2.0 Array)   219456_s_at (Human Genome U133 Plus 2.0 Array)   219457_s_at (Human Genome U133 Plus 2.0 Array)   220439_at (Human Genome U133 Plus 2.0 Array)   60471_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000216487
Ensembl peptide - ENSP00000450986
Ensembl peptide - ENSP00000452155
Ensembl peptide - ENSP00000480603
Ensembl peptide - ENSP00000450682
NCBI entrez gene - 79890     See in Manteia.
OMIM - 610223
RefSeq - XM_017021654
RefSeq - NM_001319987
RefSeq - NM_024832
RefSeq - XM_011537164
RefSeq - XM_011537165
RefSeq - XM_017021651
RefSeq - XM_017021652
RefSeq - XM_017021653
RefSeq Peptide - NP_001306916
RefSeq Peptide - NP_079108
swissprot - H0YJ83
swissprot - G3V2I7
swissprot - A0A087WWY9
swissprot - Q8TB24
swissprot - G3V534
Ensembl - ENSG00000100599
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rin3ENSDARG00000077618Danio rerio
 RIN3ENSGALG00000010806Gallus gallus
 Rin3ENSMUSG00000044456Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RIN2 / Q8WYP3 / Ras and Rab interactor 2ENSG0000013266930
RIN1 / Q13671 / Ras and Rab interactor 1ENSG0000017479121
RINL / Q6ZS11 / Ras and Rab interactor likeENSG0000018799415


Protein motifs (from Interpro)
Interpro ID Name
 IPR000159  Ras-associating (RA) domain
 IPR000980  SH2 domain
 IPR003123  VPS9 domain
 IPR035869  Ras and Rab interactor 3, SH2 domain
 IPR036860  SH2 domain superfamily
 IPR037191  VPS9 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis NAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017112 Rab guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0017137 Rab GTPase binding IDA


Pathways (from Reactome)
Pathway description
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000203668 CHML / P26374 / CHM like, Rab escort protein 2  / reaction
 ENSG00000168461 RAB31 / Q13636 / RAB31, member RAS oncogene family  / reaction
 ENSG00000057608 GDI2 / P50395 / GDP dissociation inhibitor 2  / reaction
 ENSG00000188419 CHM / P24386 / CHM, Rab escort protein 1  / reaction
 ENSG00000203879 GDI1 / P31150 / GDP dissociation inhibitor 1  / reaction






 

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