ENSMUSG00000044456


Mus musculus

Features
Gene ID: ENSMUSG00000044456
  
Biological name :Rin3
  
Synonyms : P59729 / Ras and Rab interactor 3 / Rin3
  
Possible biological names infered from orthology : Q8TB24
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: E
Gene start: 102283048
Gene end: 102390855
  
Corresponding Affymetrix probe sets: 10397853 (MoGene1.0st)   1434684_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000060771
Ensembl peptide - ENSMUSP00000098673
Ensembl peptide - ENSMUSP00000122646
Ensembl peptide - ENSMUSP00000123268
NCBI entrez gene - 217835     See in Manteia.
MGI - MGI:2385708
RefSeq - XM_011244094
RefSeq - NM_001161365
RefSeq - NM_177620
RefSeq - XM_006515741
RefSeq Peptide - NP_808288
RefSeq Peptide - NP_001154837
swissprot - P59729
swissprot - Q3U332
swissprot - Q3UZ87
swissprot - D3Z076
Ensembl - ENSMUSG00000044456
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rin3ENSDARG00000077618Danio rerio
 RIN3ENSGALG00000010806Gallus gallus
 RIN3ENSG00000100599Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rin2 / Q9D684 / Ras and Rab interactor 2 / Q8WYP3*ENSMUSG0000000176829
Rin1 / Q921Q7 / Ras and Rab interactor 1 / Q13671*ENSMUSG0000002488322
Rinl / Q80UW3 / Mus musculus Ras and Rab interactor-like (Rinl), transcript variant 2, mRNA. / Q6ZS11* / Ras and Rab interactor like*ENSMUSG0000005173515


Protein motifs (from Interpro)
Interpro ID Name
 IPR000159  Ras-associating (RA) domain
 IPR003123  VPS9 domain
 IPR035869  Ras and Rab interactor 3, SH2 domain
 IPR036860  SH2 domain superfamily
 IPR037191  VPS9 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome ISO
 cellular_componentGO:0031410 cytoplasmic vesicle ISO
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0017112 Rab guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0017137 Rab GTPase binding IEA


Pathways (from Reactome)
Pathway description
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003020 decreased circulating chloride level "reduced concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

 MP:0013279 increased fasted circulating glucose level "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
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Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000078185 Chml / choroideremia-like / P26374* / CHM like, Rab escort protein 2*  / reaction
 ENSMUSG00000021218 Gdi2 / Q61598 / Rab GDP dissociation inhibitor beta / P50395* / GDP dissociation inhibitor 2*  / reaction
 ENSMUSG00000056515 Rab31 / RAB31, member RAS oncogene family / Q13636*  / reaction
 ENSMUSG00000015291 Gdi1 / P50396 / Rab GDP dissociation inhibitor alpha / P31150* / GDP dissociation inhibitor 1*  / reaction
 ENSMUSG00000025531 Chm / choroidermia (RAB escort protein 1) / P24386* / CHM, Rab escort protein 1*  / reaction






 

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