ENSMUSG00000015291


Mus musculus

Features
Gene ID: ENSMUSG00000015291
  
Biological name :Gdi1
  
Synonyms : Gdi1 / P50396 / Rab GDP dissociation inhibitor alpha
  
Possible biological names infered from orthology : GDP dissociation inhibitor 1 / P31150
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A7.3
Gene start: 74304998
Gene end: 74311862
  
Corresponding Affymetrix probe sets: 10600390 (MoGene1.0st)   1447613_at (Mouse Genome 430 2.0 Array)   1451070_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000015435
Ensembl peptide - ENSMUSP00000122146
Ensembl peptide - ENSMUSP00000119805
NCBI entrez gene - 14567     See in Manteia.
MGI - MGI:99846
RefSeq - NM_010273
RefSeq Peptide - NP_034403
swissprot - D6RI86
swissprot - B7FAU8
swissprot - P50396
Ensembl - ENSMUSG00000015291
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gdi1ENSDARG00000056122Danio rerio
 GDI1ENSG00000203879Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gdi2 / Q61598 / Rab GDP dissociation inhibitor beta / P50395* / GDP dissociation inhibitor 2*ENSMUSG0000002121885
Chml / choroideremia-like / P26374* / CHM like, Rab escort protein 2*ENSMUSG0000007818525
Chm / choroidermia (RAB escort protein 1) / P24386* / CHM, Rab escort protein 1*ENSMUSG0000002553124


Protein motifs (from Interpro)
Interpro ID Name
 IPR000806  Rab GDI protein
 IPR018203  GDP dissociation inhibitor
 IPR036188  FAD/NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0032482 Rab protein signal transduction ISS
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045773 positive regulation of axon extension IEA
 biological_processGO:0050771 negative regulation of axonogenesis IEA
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0090315 negative regulation of protein targeting to membrane IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043209 myelin sheath IEA
 molecular_functionGO:0005092 GDP-dissociation inhibitor activity IEA
 molecular_functionGO:0005093 Rab GDP-dissociation inhibitor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0017137 Rab GTPase binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Mllt3tm1Thr/Mllt3tm1Thr
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Gdi1tm1Toni/Y
Genetic Background: B6N.129S7-Gdi1tm1Toni

 MP:0002761 abnormal hippocampal mossy fiber morphology "absence or misprojection of axons of neuronal cells in the dentate gyrus" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:4978]
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Allelic Composition: Mllt3tm1Thr/Mllt3tm1Thr
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
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Allelic Composition: Achetm1.1Pata/Achetm1.1Pata
Genetic Background: involves: 129X1/SvJ

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Achetm1.1Pata/Achetm1.1Pata
Genetic Background: involves: 129X1/SvJ

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Mllt3tm1Thr/Mllt3tm1Thr
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Gdi1tm1Toni/Y
Genetic Background: B6N.129S7-Gdi1tm1Toni

 MP:0002919 enhanced paired-pulse facilitation "increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Gdi1tm1Toni/Y
Genetic Background: B6N.129S7-Gdi1tm1Toni

Allelic Composition: Gdi1tm1Ytk/Gdi1tm1Ytk
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * DBA/2)

 MP:0003863 decreased aggression towards mice "when compared to controls, subjects exhibit less than normal level of domineering, assaultive posture and/or hostile physical action towards other mice" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Mllt3tm1Thr/Mllt3tm1Thr
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004494 abnormal synaptic glutamate release "aberrant secretion across synapses of the major excitatory neurotransmitter of the central nervous system (CNS), which acts through both ligand gated ion channels (ionotropic receptors) and G protein-coupled (metabotropic) receptors" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gdi1tm1Toni/Y
Genetic Background: B6N.129S7-Gdi1tm1Toni

 MP:0004495 decreased synaptic glutamate release "reduced secretion across synapses of the major excitatory neurotransmitter of the central nervous system (CNS), which acts through both ligand gated ion channels (ionotropic receptors) and G protein-coupled (metabotropic) receptors" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gdi1tm1Toni/Y
Genetic Background: B6N.129S7-Gdi1tm1Toni

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gdi1tm1Toni/Y
Genetic Background: B6N.129S7-Gdi1tm1Toni

 MP:0008267 abnormal hippocampus CA3 region morphology 
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Allelic Composition: Mllt3tm1Thr/Mllt3tm1Thr
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mllt3tm1Thr/Mllt3tm1Thr
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Gdi1tm1Toni/Y
Genetic Background: B6N.129S7-Gdi1tm1Toni

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020149 Rab1 / P62821 / Ras-related protein Rab-1A / RAB1A* / P62820* / RAB1A, member RAS oncogene family*  / complex
 ENSMUSG00000020132 Rab21 / P35282 / RAB21, member RAS oncogene family / Q9UL25*  / complex
 ENSMUSG00000020671 Rab10 / P61027 / RAB10, member RAS oncogene family / P61026*  / complex
 ENSMUSG00000032202 Q9ERI2 / Rab27a / RAB27A, member RAS oncogene family / P51159*  / complex
 ENSMUSG00000029518 Rab35 / Q6PHN9 / RAB35, member RAS oncogene family / Q15286*  / complex
 ENSMUSG00000017831 Rab5a / Q9CQD1 / Ras-related protein Rab-5A / P20339* / RAB5A, member RAS oncogene family*  / complex
 ENSMUSG00000031840 Rab3a / P63011 / RAB3A, member RAS oncogene family / P20336*  / complex
 ENSMUSG00000056515 Rab31 / RAB31, member RAS oncogene family / Q13636*  / complex
 ENSMUSG00000079477 Rab7 / P51150 / RAB7, member RAS oncogene family / RAB7A* / P51149* / RAB7A, member RAS oncogene family*  / complex
 ENSMUSG00000003037 Rab8a / P55258 / RAB8A, member RAS oncogene family / P61006*  / complex
 ENSMUSG00000023460 Rab12 / P35283 / Ras-related protein Rab-12 / Q6IQ22* / RAB12, member RAS oncogene family*  / complex
 ENSMUSG00000027935 Rab13 / Q9DD03 / Ras-related protein Rab-13 / P51153* / RAB13, member RAS oncogene family*  / complex
 ENSMUSG00000073639 Rab18 / P35293 / RAB18, member RAS oncogene family / Q9NP72*  / complex
 ENSMUSG00000030704 Rab6a / P35279 / RAB6A, member RAS oncogene family / RAB6C* / RAB6D* / Q9H0N0* / P20340* / RAB6C, member RAS oncogene family* / RAB6D, member RAS oncogene family*  / complex
 ENSMUSG00000026878 Rab14 / Q91V41 / RAB14, member RAS oncogene family / P61106*  / complex
 ENSMUSG00000019832 Rab32 / Q9CZE3 / RAB32, member RAS oncogene family / Q13637*  / complex
 ENSMUSG00000002668 Q8CFK6 / Dennd1c / DENN domain-containing protein 1C / Q8IV53* / DENN domain containing 1C*  / reaction
 ENSMUSG00000026867 Gapvd1 / Q6PAR5 / GTPase-activating protein and VPS9 domain-containing protein 1 / Q14C86* / GTPase activating protein and VPS9 domains 1*  / reaction
 ENSMUSG00000028468 Rgp1 / Q8BHT7 / RAB6A-GEF complex partner protein 2 / Q92546* / RGP1 homolog, RAB6A GEF complex partner 1*  / reaction
 ENSMUSG00000036104 Q80UJ7 / Rab3gap1 / Rab3 GTPase-activating protein catalytic subunit / Q15042* / RAB3 GTPase activating protein catalytic subunit 1*  / reaction
 ENSMUSG00000038456 Q8C4S8 / Dennd2a / DENN domain-containing protein 2A / Q9ULE3* / DENN domain containing 2A*  / reaction
 ENSMUSG00000036661 A2RT67 / Dennd3 / DENN domain-containing protein 3 / A2RUS2* / DENN domain containing 3*  / reaction
 ENSMUSG00000042328 Hps4 / Q99KG7 / Hermansky-Pudlak syndrome 4 protein homolog / Q9NQG7* / HPS4, biogenesis of lysosomal organelles complex 3 subunit 2*  / reaction
 ENSMUSG00000053641 Dennd4a / DENN domain containing 4A / Q7Z401*  / reaction
 ENSMUSG00000034867 Q3UMR0 / Ankrd27 / Ankyrin repeat domain-containing protein 27 / Q96NW4* / ankyrin repeat domain 27*  / reaction
 ENSMUSG00000029617 Ccz1 / Q8C1Y8 / Vacuolar fusion / CCZ1B* / P86790* / P86791* / CCZ1 homolog, vacuolar protein trafficking and biogenesis associated* / CCZ1 homolog B, vacuolar protein trafficking and bio...  / reaction
 ENSMUSG00000032583 Mon1a / MON1 homolog A, secretory trafficking associated / Q86VX9*  / reaction
 ENSMUSG00000040818 Q8BH65 / Dennd6a / Protein DENND6A / Q8IWF6* / DENN domain containing 6A*  / reaction
 ENSMUSG00000038658 Ric1 / Q69ZJ7 / RAB6A-GEF complex partner protein 1 / Q4ADV7* / RIC1 homolog, RAB6A GEF complex partner 1*  / reaction
 ENSMUSG00000079316 Rab9 / Q9R0M6 / RAB9, member RAS oncogene family / RAB9A* / P51151* / RAB9A, member RAS oncogene family*  / complex
 ENSMUSG00000020849 Ywhae / P62259 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide / P62258* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation prote...  / reaction
 ENSMUSG00000044456 Rin3 / P59729 / Ras and Rab interactor 3 / Q8TB24*  / reaction
 ENSMUSG00000038024 A6H8H2 / Dennd4c / DENN domain-containing protein 4C / Q5VZ89* / DENN domain containing 4C*  / reaction
 ENSMUSG00000039318 Rab3gap2 / RAB3 GTPase activating non-catalytic protein subunit 2 / Q9H2M9*  / reaction
 ENSMUSG00000055069 Rab39 / Q8BHD0 / RAB39, member RAS oncogene family / Q14964* / RAB39A* / RAB39A, member RAS oncogene family*  / complex
 ENSMUSG00000035901 Q6PAL8 / Dennd5a / DENN domain-containing protein 5A / Q6IQ26* / DENN domain containing 5A*  / reaction
 ENSMUSG00000015377 Q9D9V7 / Dennd6b / Protein DENND6B / Q8NEG7* / DENN domain containing 6B*  / reaction
 ENSMUSG00000056268 Q3U1T9 / Dennd1b / DENN domain-containing protein 1B / Q6P3S1* / DENN domain containing 1B*  / reaction
 ENSMUSG00000035392 Q8K382 / Dennd1a / DENN domain-containing protein 1A / Q8TEH3* / DENN domain containing 1A*  / reaction
 ENSMUSG00000030559 Rab38 / Q8QZZ8 / RAB38, member RAS oncogene family / P57729*  / complex
 ENSMUSG00000042404 Q3U1Y4 / Dennd4b / Mus musculus DENN/MADD domain containing 4B (Dennd4b), transcript variant 2, mRNA. / O75064* / DENN domain containing 4B*  / reaction
 ENSMUSG00000024663 Q8VDV3 / Rab3il1 / Mus musculus RAB3A interacting protein (rabin3)-like 1 (Rab3il1), transcript variant 2, mRNA. / Q8TBN0* / RAB3A interacting protein like 1*  / reaction
 ENSMUSG00000030313 A2RSQ0 / Dennd5b / DENN domain-containing protein 5B / Q6ZUT9* / DENN domain containing 5B*  / reaction
 ENSMUSG00000036529 Sbf1 / Q6ZPE2 / SET binding factor 1 / O95248*  / reaction






 

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