ENSMUSG00000026867


Mus musculus

Features
Gene ID: ENSMUSG00000026867
  
Biological name :Gapvd1
  
Synonyms : Gapvd1 / GTPase-activating protein and VPS9 domain-containing protein 1 / Q6PAR5
  
Possible biological names infered from orthology : GTPase activating protein and VPS9 domains 1 / Q14C86
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: B
Gene start: 34674594
Gene end: 34755232
  
Corresponding Affymetrix probe sets: 10481870 (MoGene1.0st)   1429454_at (Mouse Genome 430 2.0 Array)   1429455_at (Mouse Genome 430 2.0 Array)   1444066_at (Mouse Genome 430 2.0 Array)   1453146_at (Mouse Genome 430 2.0 Array)   1457093_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000129138
Ensembl peptide - ENSMUSP00000126225
Ensembl peptide - ENSMUSP00000127268
Ensembl peptide - ENSMUSP00000028224
Ensembl peptide - ENSMUSP00000099864
Ensembl peptide - ENSMUSP00000108723
Ensembl peptide - ENSMUSP00000108725
Ensembl peptide - ENSMUSP00000108727
Ensembl peptide - ENSMUSP00000108735
Ensembl peptide - ENSMUSP00000120138
NCBI entrez gene - 66691     See in Manteia.
MGI - MGI:1913941
RefSeq - XM_017319199
RefSeq - NM_025709
RefSeq - XM_011239145
RefSeq - XM_011239147
RefSeq - XM_011239148
RefSeq - XM_011239149
RefSeq - XM_011239150
RefSeq - XM_017319195
RefSeq - XM_017319196
RefSeq - XM_017319197
RefSeq - XM_017319198
RefSeq Peptide - NP_079985
RefSeq Peptide - NP_001343370
swissprot - F7ADQ2
swissprot - F7ADS7
swissprot - F7ADT6
swissprot - F6UFP6
swissprot - E9Q0D1
swissprot - F6X819
swissprot - Q6PAR5
swissprot - F6YRL2
Ensembl - ENSMUSG00000026867
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gapvd1ENSDARG00000090183Danio rerio
 GAPVD1ENSGALG00000000993Gallus gallus
 GAPVD1ENSG00000165219Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9JM13 / Rabgef1 / Rab5 GDP/GTP exchange factor / Q9UJ41* / AC027644.4* / RAB guanine nucleotide exchange factor 1*ENSMUSG000000253407


Protein motifs (from Interpro)
Interpro ID Name
 IPR001936  Ras GTPase-activating domain
 IPR003123  VPS9 domain
 IPR008936  Rho GTPase activation protein
 IPR037191  VPS9 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0051223 regulation of protein transport IMP
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity ISO
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0032794 GTPase activating protein binding ISO
 molecular_functionGO:0045296 cadherin binding ISO


Pathways (from Reactome)
Pathway description
Clathrin-mediated endocytosis
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025531 Chm / choroidermia (RAB escort protein 1) / P24386* / CHM, Rab escort protein 1*  / reaction
 ENSMUSG00000056515 Rab31 / RAB31, member RAS oncogene family / Q13636*  / reaction
 ENSMUSG00000015291 Gdi1 / P50396 / Rab GDP dissociation inhibitor alpha / P31150* / GDP dissociation inhibitor 1*  / reaction
 ENSMUSG00000021218 Gdi2 / Q61598 / Rab GDP dissociation inhibitor beta / P50395* / GDP dissociation inhibitor 2*  / reaction
 ENSMUSG00000017831 Rab5a / Q9CQD1 / Ras-related protein Rab-5A / P20339* / RAB5A, member RAS oncogene family*  / complex
 ENSMUSG00000078185 Chml / choroideremia-like / P26374* / CHM like, Rab escort protein 2*  / reaction






 

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