ENSMUSG00000040818


Mus musculus

Features
Gene ID: ENSMUSG00000040818
  
Biological name :Dennd6a
  
Synonyms : Dennd6a / Protein DENND6A / Q8BH65
  
Possible biological names infered from orthology : DENN domain containing 6A / Q8IWF6
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: A3
Gene start: 26573856
Gene end: 26634322
  
Corresponding Affymetrix probe sets: 10413282 (MoGene1.0st)   1437253_at (Mouse Genome 430 2.0 Array)   1451568_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144906
Ensembl peptide - ENSMUSP00000153187
Ensembl peptide - ENSMUSP00000153200
Ensembl peptide - ENSMUSP00000039361
Ensembl peptide - ENSMUSP00000152966
NCBI entrez gene - 211922     See in Manteia.
MGI - MGI:2442980
RefSeq - XM_006518779
RefSeq - NM_001134465
RefSeq - NM_001285466
RefSeq - NM_001285467
RefSeq - NM_145969
RefSeq - XM_006518778
RefSeq Peptide - NP_001272395
RefSeq Peptide - NP_001272396
RefSeq Peptide - NP_666081
RefSeq Peptide - NP_001127937
swissprot - Q8BH65
swissprot - A0A286YDD5
Ensembl - ENSMUSG00000040818
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dennd6aaENSDARG00000030239Danio rerio
 DENND6AENSGALG00000005656Gallus gallus
 Q8IWF6ENSG00000174839Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9D9V7 / Dennd6b / Protein DENND6B / Q8NEG7* / DENN domain containing 6B*ENSMUSG0000001537756


Protein motifs (from Interpro)
Interpro ID Name
 IPR018307  AVL9/DENND6 domain
 IPR024224  DENND6
 IPR037516  Tripartite DENN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0043547 positive regulation of GTPase activity IBA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:2000049 positive regulation of cell-cell adhesion mediated by cadherin IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0055037 recycling endosome IBA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0017112 Rab guanyl-nucleotide exchange factor activity IBA


Pathways (from Reactome)
Pathway description
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015291 Gdi1 / P50396 / Rab GDP dissociation inhibitor alpha / P31150* / GDP dissociation inhibitor 1*  / reaction
 ENSMUSG00000021218 Gdi2 / Q61598 / Rab GDP dissociation inhibitor beta / P50395* / GDP dissociation inhibitor 2*  / reaction
 ENSMUSG00000026878 Rab14 / Q91V41 / RAB14, member RAS oncogene family / P61106*  / reaction
 ENSMUSG00000025531 Chm / choroidermia (RAB escort protein 1) / P24386* / CHM, Rab escort protein 1*  / reaction
 ENSMUSG00000078185 Chml / choroideremia-like / P26374* / CHM like, Rab escort protein 2*  / reaction






 

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