ENSG00000174839


Homo sapiens

Features
Gene ID: ENSG00000174839
  
Biological name :DENND6A
  
Synonyms : DENND6A / DENN domain containing 6A / Q8IWF6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p14.3
Gene start: 57625457
Gene end: 57693089
  
Corresponding Affymetrix probe sets: 226965_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000311401
Ensembl peptide - ENSP00000419334
Ensembl peptide - ENSP00000419570
NCBI entrez gene - 201627     See in Manteia.
RefSeq - XM_017005864
RefSeq - NM_152678
RefSeq - XM_006713019
RefSeq - XM_006713020
RefSeq Peptide - NP_689891
swissprot - Q8IWF6
swissprot - H7C5D0
swissprot - H7C598
Ensembl - ENSG00000174839
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dennd6aaENSDARG00000030239Danio rerio
 DENND6AENSGALG00000005656Gallus gallus
 Q8BH65ENSMUSG00000040818Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8NEG7 / DENND6B / DENN domain containing 6BENSG0000020559355


Protein motifs (from Interpro)
Interpro ID Name
 IPR018307  AVL9/DENND6 domain
 IPR024224  DENND6
 IPR037516  Tripartite DENN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:2000049 positive regulation of cell-cell adhesion mediated by cadherin IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0055037 recycling endosome IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0017112 Rab guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000188419 CHM / P24386 / CHM, Rab escort protein 1  / reaction
 ENSG00000119396 RAB14 / P61106 / RAB14, member RAS oncogene family  / reaction
 ENSG00000057608 GDI2 / P50395 / GDP dissociation inhibitor 2  / reaction
 ENSG00000203668 CHML / P26374 / CHM like, Rab escort protein 2  / reaction
 ENSG00000203879 GDI1 / P31150 / GDP dissociation inhibitor 1  / reaction






 

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