ENSG00000119396


Homo sapiens

Features
Gene ID: ENSG00000119396
  
Biological name :RAB14
  
Synonyms : P61106 / RAB14 / RAB14, member RAS oncogene family
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: q33.2
Gene start: 121178137
Gene end: 121223014
  
Corresponding Affymetrix probe sets: 200927_s_at (Human Genome U133 Plus 2.0 Array)   200928_s_at (Human Genome U133 Plus 2.0 Array)   211503_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000362946
Ensembl peptide - ENSP00000400107
NCBI entrez gene - 51552     See in Manteia.
OMIM - 612673
RefSeq - NM_016322
RefSeq Peptide - NP_057406
swissprot - A0A024R845
swissprot - P61106
swissprot - X6RFL8
Ensembl - ENSG00000119396
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rab14ENSDARG00000074246Danio rerio
 RAB14ENSGALG00000001474Gallus gallus
 Rab14ENSMUSG00000026878Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RAB4A / P20338 / RAB4A, member RAS oncogene familyENSG0000016811859
RAB4B-EGLN2 / RAB4B-EGLN2 readthrough (NMD candidate)ENSG0000017157058
RAB4B / P61018 / RAB4B, member RAS oncogene familyENSG0000016757858
RAB2A / P61019 / RAB2A, member RAS oncogene familyENSG0000010438856
RAB2B / Q8WUD1 / RAB2B, member RAS oncogene familyENSG0000012947255
Q15907 / RAB11B / RAB11B, member RAS oncogene familyENSG0000018523643
P62491 / RAB11A / RAB11A, member RAS oncogene familyENSG0000010376943
RAB25 / P57735 / RAB25, member RAS oncogene familyENSG0000013269840
RAB18 / Q9NP72 / RAB18, member RAS oncogene familyENSG0000009924639
Q14964 / RAB39A / RAB39A, member RAS oncogene familyENSG0000017933139
Q96DA2 / RAB39B / RAB39B, member RAS oncogene familyENSG0000015596136
RAB42 / Q8N4Z0 / RAB42, member RAS oncogene familyENSG0000018806014


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030702  Ras-related protein Rab14


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006661 phosphatidylinositol biosynthetic process TAS
 biological_processGO:0006895 Golgi to endosome transport IEA
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway ISS
 biological_processGO:0009790 embryo development ISS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport NAS
 biological_processGO:0030100 regulation of endocytosis IBA
 biological_processGO:0032456 endocytic recycling IEA
 biological_processGO:0032880 regulation of protein localization IDA
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0046907 intracellular transport NAS
 biological_processGO:0090382 phagosome maturation IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005764 lysosome ISS
 cellular_componentGO:0005765 lysosomal membrane HDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome ISS
 cellular_componentGO:0005770 late endosome ISS
 cellular_componentGO:0005791 rough endoplasmic reticulum ISS
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005795 Golgi stack ISS
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030140 trans-Golgi network transport vesicle ISS
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031901 early endosome membrane TAS
 cellular_componentGO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network ISS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0045335 phagocytic vesicle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 cellular_componentGO:0055037 recycling endosome IEA
 cellular_componentGO:0055038 recycling endosome membrane TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0070821 tertiary granule membrane TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019003 GDP binding IDA
 molecular_functionGO:0031489 myosin V binding IPI


Pathways (from Reactome)
Pathway description
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Synthesis of PIPs at the plasma membrane
Neutrophil degranulation
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000174839 Q8IWF6 / DENND6A / DENN domain containing 6A  / reaction
 ENSG00000168118 RAB4A / P20338 / RAB4A, member RAS oncogene family  / reaction / complex
 ENSG00000144566 RAB5A / P20339 / RAB5A, member RAS oncogene family  / reaction / complex
 ENSG00000057608 GDI2 / P50395 / GDP dissociation inhibitor 2  / complex
 ENSG00000203879 GDI1 / P31150 / GDP dissociation inhibitor 1  / complex
 ENSG00000188419 CHM / P24386 / CHM, Rab escort protein 1  / complex
 ENSG00000203668 CHML / P26374 / CHM like, Rab escort protein 2  / complex
 ENSG00000176783 RUFY1 / Q96T51 / RUN and FYVE domain containing 1  / reaction / complex
 ENSG00000205593 Q8NEG7 / DENND6B / DENN domain containing 6B  / reaction






 

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