ENSG00000103769


Homo sapiens

Features
Gene ID: ENSG00000103769
  
Biological name :RAB11A
  
Synonyms : P62491 / RAB11A / RAB11A, member RAS oncogene family
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q22.31
Gene start: 65726054
Gene end: 65891991
  
Corresponding Affymetrix probe sets: 200863_s_at (Human Genome U133 Plus 2.0 Array)   200864_s_at (Human Genome U133 Plus 2.0 Array)   234998_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000456420
Ensembl peptide - ENSP00000454673
Ensembl peptide - ENSP00000456638
Ensembl peptide - ENSP00000455567
Ensembl peptide - ENSP00000261890
Ensembl peptide - ENSP00000454381
NCBI entrez gene - 8766     See in Manteia.
OMIM - 605570
RefSeq - NM_004663
RefSeq - NM_001206836
RefSeq Peptide - NP_001193765
RefSeq Peptide - NP_004654
swissprot - H3BSC1
swissprot - B4DQU5
swissprot - P62491
swissprot - A0A024R5Z8
swissprot - H3BMH2
swissprot - H3BN38
Ensembl - ENSG00000103769
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q5ZJN2ENSGALG00000007615Gallus gallus
 P62492ENSMUSG00000004771Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q15907 / RAB11B / RAB11B, member RAS oncogene familyENSG0000018523691
RAB25 / P57735 / RAB25, member RAS oncogene familyENSG0000013269860
RAB2B / Q8WUD1 / RAB2B, member RAS oncogene familyENSG0000012947245
RAB2A / P61019 / RAB2A, member RAS oncogene familyENSG0000010438844
RAB4B-EGLN2 / RAB4B-EGLN2 readthrough (NMD candidate)ENSG0000017157043
RAB4A / P20338 / RAB4A, member RAS oncogene familyENSG0000016811843
RAB14 / P61106 / RAB14, member RAS oncogene familyENSG0000011939643
RAB4B / P61018 / RAB4B, member RAS oncogene familyENSG0000016757843
Q96DA2 / RAB39B / RAB39B, member RAS oncogene familyENSG0000015596140
RAB18 / Q9NP72 / RAB18, member RAS oncogene familyENSG0000009924638
Q14964 / RAB39A / RAB39A, member RAS oncogene familyENSG0000017933138
RAB42 / Q8N4Z0 / RAB42, member RAS oncogene familyENSG0000018806013


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003091 renal water homeostasis TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007080 mitotic metaphase plate congression IMP
 biological_processGO:0010634 positive regulation of epithelial cell migration IMP
 biological_processGO:0010796 regulation of multivesicular body size IMP
 biological_processGO:0010971 positive regulation of G2/M transition of mitotic cell cycle IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IDA
 biological_processGO:0030953 astral microtubule organization IMP
 biological_processGO:0031175 neuron projection development IMP
 biological_processGO:0032402 melanosome transport ISS
 biological_processGO:0032465 regulation of cytokinesis IMP
 biological_processGO:0036258 multivesicular body assembly IMP
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0045773 positive regulation of axon extension IEA
 biological_processGO:0048169 regulation of long-term neuronal synaptic plasticity IEA
 biological_processGO:0048227 plasma membrane to endosome transport NAS
 biological_processGO:0051223 regulation of protein transport IEA
 biological_processGO:0051650 establishment of vesicle localization IMP
 biological_processGO:0060627 regulation of vesicle-mediated transport IMP
 biological_processGO:0072594 establishment of protein localization to organelle IMP
 biological_processGO:0072659 protein localization to plasma membrane IDA
 biological_processGO:0090150 establishment of protein localization to membrane IMP
 biological_processGO:0090307 mitotic spindle assembly IMP
 biological_processGO:0097711 ciliary basal body-plasma membrane docking TAS
 biological_processGO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane IEA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IEA
 biological_processGO:1990182 exosomal secretion IMP
 cellular_componentGO:0000922 spindle pole IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005771 multivesicular body IDA
 cellular_componentGO:0005794 Golgi apparatus HDA
 cellular_componentGO:0005802 trans-Golgi network IDA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IDA
 cellular_componentGO:0005828 kinetochore microtubule IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030133 transport vesicle IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane TAS
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031982 vesicle IDA
 cellular_componentGO:0032154 cleavage furrow IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0045335 phagocytic vesicle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0055037 recycling endosome ISS
 cellular_componentGO:0055038 recycling endosome membrane TAS
 cellular_componentGO:0070062 extracellular exosome IDA
 cellular_componentGO:0098837 postsynaptic recycling endosome IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0008017 microtubule binding IDA
 molecular_functionGO:0019905 syntaxin binding NAS
 molecular_functionGO:0031489 myosin V binding IPI


Pathways (from Reactome)
Pathway description
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Vasopressin regulates renal water homeostasis via Aquaporins
Anchoring of the basal body to the plasma membrane
VxPx cargo-targeting to cilium
TBC/RABGAPs
RAB geranylgeranylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000070729 CNGB1 / Q14028 / cyclic nucleotide gated channel beta 1  / complex / reaction
 ENSG00000127328 Q96QF0 / RAB3IP / RAB3A interacting protein  / complex / reaction
 ENSG00000177169 ULK1 / O75385 / unc-51 like autophagy activating kinase 1  / reaction / complex
 ENSG00000144061 NPHP1 / O15259 / nephrocystin 1  / reaction / complex
 ENSG00000132405 Q9P2M4 / TBC1D14 / TBC1 domain family member 14  / reaction / complex
 ENSG00000132259 CNGA4 / Q8IV77 / cyclic nucleotide gated channel alpha 4  / complex / reaction
 ENSG00000008710 PKD1 / P98161 / polycystin 1, transient receptor potential channel interacting  / complex / reaction
 ENSG00000183862 CNGA2 / Q16280 / cyclic nucleotide gated channel alpha 2  / complex / reaction
 ENSG00000167461 RAB8A / P61006 / RAB8A, member RAS oncogene family  / reaction / complex
 ENSG00000090565 O75154 / RAB11FIP3 / RAB11 family interacting protein 3  / complex / reaction
 ENSG00000103494 Q68CZ1 / RPGRIP1L / RPGRIP1 like  / complex / reaction
 ENSG00000131697 NPHP4 / O75161 / nephrocystin 4  / complex / reaction
 ENSG00000163914 RHO / P08100 / rhodopsin  / complex / reaction
 ENSG00000167306 MYO5B / Q9ULV0 / myosin VB  / complex
 ENSG00000168374 ARF4 / P18085 / ADP ribosylation factor 4  / complex / reaction
 ENSG00000107560 Q7L804 / RAB11FIP2 / RAB11 family interacting protein 2  / complex
 ENSG00000153317 ASAP1 / Q9ULH1 / ArfGAP with SH3 domain, ankyrin repeat and PH domain 1  / reaction / complex






 

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