ENSG00000153317


Homo sapiens

Features
Gene ID: ENSG00000153317
  
Biological name :ASAP1
  
Synonyms : ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 / ASAP1 / Q9ULH1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: q24.22
Gene start: 130052104
Gene end: 130443660
  
Corresponding Affymetrix probe sets: 221039_s_at (Human Genome U133 Plus 2.0 Array)   224790_at (Human Genome U133 Plus 2.0 Array)   224791_at (Human Genome U133 Plus 2.0 Array)   224796_at (Human Genome U133 Plus 2.0 Array)   236533_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000429391
Ensembl peptide - ENSP00000428936
Ensembl peptide - ENSP00000429614
Ensembl peptide - ENSP00000430917
Ensembl peptide - ENSP00000429900
Ensembl peptide - ENSP00000429829
Ensembl peptide - ENSP00000350297
Ensembl peptide - ENSP00000428463
Ensembl peptide - ENSP00000428629
NCBI entrez gene - 50807     See in Manteia.
OMIM - 605953
RefSeq - XM_017013469
RefSeq - XM_005250925
RefSeq - XM_006716563
RefSeq - XM_006716564
RefSeq - XM_006716565
RefSeq - XM_006716566
RefSeq - XM_011517052
RefSeq - XM_011517053
RefSeq - XM_017013467
RefSeq - XM_017013468
RefSeq - NM_001247996
RefSeq - NM_018482
RefSeq Peptide - NP_001234925
RefSeq Peptide - NP_060952
swissprot - E5RFD9
swissprot - H0YBF7
swissprot - E5RHD7
swissprot - Q9ULH1
swissprot - A0A0A0MRE5
swissprot - H0YBM4
swissprot - E5RHA9
Ensembl - ENSG00000153317
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 asap1aENSDARG00000029463Danio rerio
 asap1bENSDARG00000039729Danio rerio
 ASAP1ENSGALG00000037618Gallus gallus
 Asap1ENSMUSG00000022377Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ASAP2 / O43150 / ArfGAP with SH3 domain, ankyrin repeat and PH domain 2ENSG0000015169354
ASAP3 / Q8TDY4 / ArfGAP with SH3 domain, ankyrin repeat and PH domain 3ENSG0000008828037
ACAP3 / Q96P50 / ArfGAP with coiled-coil, ankyrin repeat and PH domains 3ENSG0000013158416
ACAP2 / Q15057 / ArfGAP with coiled-coil, ankyrin repeat and PH domains 2ENSG0000011433116
ACAP1 / Q15027 / ArfGAP with coiled-coil, ankyrin repeat and PH domains 1ENSG0000007281815
AGAP3 / Q96P47 / ArfGAP with GTPase domain, ankyrin repeat and PH domain 3ENSG0000013361214
AGAP1 / Q9UPQ3 / ArfGAP with GTPase domain, ankyrin repeat and PH domain 1ENSG0000015798514
AGAP2 / Q99490 / ArfGAP with GTPase domain, ankyrin repeat and PH domain 2ENSG0000013543913
AGAP6 / Q5VW22 / ArfGAP with GTPase domain, ankyrin repeat and PH domain 6ENSG0000020414911
AGAP4 / Q96P64 / ArfGAP with GTPase domain, ankyrin repeat and PH domain 4ENSG0000018823411
AGAP5 / A6NIR3 / ArfGAP with GTPase domain, ankyrin repeat and PH domain 5ENSG0000017265011
AGAP9 / Q5VTM2 / ArfGAP with GTPase domain, ankyrin repeat and PH domain 9ENSG0000020417210


Protein motifs (from Interpro)
Interpro ID Name
 IPR001164  Arf GTPase activating protein
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR002110  Ankyrin repeat
 IPR011993  PH-like domain superfamily
 IPR020683  Ankyrin repeat-containing domain
 IPR027267  AH/BAR domain superfamily
 IPR036028  SH3-like domain superfamily
 IPR036770  Ankyrin repeat-containing domain superfamily
 IPR037278  ARFGAP/RecO-like zinc finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:0061000 negative regulation of dendritic spine development IEA
 biological_processGO:0071803 positive regulation of podosome assembly IEA
 biological_processGO:1903527 positive regulation of membrane tubulation IEA
 cellular_componentGO:0002102 podosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031253 cell projection membrane IEA
 cellular_componentGO:0043197 dendritic spine IEA
 molecular_functionGO:0001786 phosphatidylserine binding IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding IEA
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IEA
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
VxPx cargo-targeting to cilium


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000167461 RAB8A / P61006 / RAB8A, member RAS oncogene family  / complex / reaction
 ENSG00000070729 CNGB1 / Q14028 / cyclic nucleotide gated channel beta 1  / complex / reaction
 ENSG00000127328 Q96QF0 / RAB3IP / RAB3A interacting protein  / reaction / complex
 ENSG00000153317 ASAP1 / Q9ULH1 / ArfGAP with SH3 domain, ankyrin repeat and PH domain 1  / complex
 ENSG00000103769 P62491 / RAB11A / RAB11A, member RAS oncogene family  / complex / reaction
 ENSG00000008710 PKD1 / P98161 / polycystin 1, transient receptor potential channel interacting  / reaction / complex
 ENSG00000183862 CNGA2 / Q16280 / cyclic nucleotide gated channel alpha 2  / reaction / complex
 ENSG00000090565 O75154 / RAB11FIP3 / RAB11 family interacting protein 3  / reaction / complex
 ENSG00000168374 ARF4 / P18085 / ADP ribosylation factor 4  / reaction / complex
 ENSG00000132259 CNGA4 / Q8IV77 / cyclic nucleotide gated channel alpha 4  / reaction / complex
 ENSG00000163914 RHO / P08100 / rhodopsin  / reaction / complex






 

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