ENSG00000167461


Homo sapiens

Features
Gene ID: ENSG00000167461
  
Biological name :RAB8A
  
Synonyms : P61006 / RAB8A / RAB8A, member RAS oncogene family
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.11
Gene start: 16111629
Gene end: 16134234
  
Corresponding Affymetrix probe sets: 208819_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000300935
Ensembl peptide - ENSP00000467501
NCBI entrez gene - 4218     See in Manteia.
OMIM - 165040
RefSeq - NM_005370
RefSeq - XM_011528020
RefSeq Peptide - NP_005361
swissprot - A0A024R7I3
swissprot - P61006
Ensembl - ENSG00000167461
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rab8aENSDARG00000067920Danio rerio
 RAB8AENSGALG00000028851Gallus gallus
 Rab8aENSMUSG00000003037Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RAB8B / Q92930 / RAB8B, member RAS oncogene familyENSG0000016612884
RAB10 / P61026 / RAB10, member RAS oncogene familyENSG0000008473368
RAB13 / P51153 / RAB13, member RAS oncogene familyENSG0000014354561
RAB3C / Q96E17 / RAB3C, member RAS oncogene familyENSG0000015293250
RAB3A / P20336 / RAB3A, member RAS oncogene familyENSG0000010564950
RAB3D / O95716 / RAB3D, member RAS oncogene familyENSG0000010551449
RAB3B / P20337 / RAB3B, member RAS oncogene familyENSG0000016921349
RAB15 / P59190 / RAB15, member RAS oncogene familyENSG0000013999848
RAB12 / Q6IQ22 / RAB12, member RAS oncogene familyENSG0000020641844
P51159 / RAB27A / RAB27A, member RAS oncogene familyENSG0000006997442
O00194 / RAB27B / RAB27B, member RAS oncogene familyENSG0000004135340
RASEF / Q8IZ41 / RAS and EF-hand domain containingENSG0000016510538
RAB44 / RAB44, member RAS oncogene familyENSG0000025558735


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle TAS
 biological_processGO:0006904 vesicle docking involved in exocytosis IDA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0007409 axonogenesis ISS
 biological_processGO:0009306 protein secretion IBA
 biological_processGO:0010506 regulation of autophagy IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0017157 regulation of exocytosis IBA
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0032869 cellular response to insulin stimulus ISS
 biological_processGO:0032880 regulation of protein localization IEA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0048169 regulation of long-term neuronal synaptic plasticity IEA
 biological_processGO:0048210 Golgi vesicle fusion to target membrane IDA
 biological_processGO:0051223 regulation of protein transport IEA
 biological_processGO:0060271 cilium assembly IDA
 biological_processGO:0072659 protein localization to plasma membrane IBA
 biological_processGO:0097711 ciliary basal body-plasma membrane docking TAS
 biological_processGO:0098969 neurotransmitter receptor transport to postsynaptic membrane IEA
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0008021 synaptic vesicle IBA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030140 trans-Golgi network transport vesicle IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030667 secretory granule membrane IBA
 cellular_componentGO:0030670 phagocytic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032588 trans-Golgi network membrane TAS
 cellular_componentGO:0036064 ciliary basal body IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0045335 phagocytic vesicle IEA
 cellular_componentGO:0055037 recycling endosome IEA
 cellular_componentGO:0055038 recycling endosome membrane TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0097546 ciliary base IEA
 cellular_componentGO:0097730 non-motile cilium IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IDA
 molecular_functionGO:0017137 Rab GTPase binding ISS
 molecular_functionGO:0019003 GDP binding IDA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0031489 myosin V binding IPI


Pathways (from Reactome)
Pathway description
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Regulation of PLK1 Activity at G2/M Transition
Anchoring of the basal body to the plasma membrane
VxPx cargo-targeting to cilium
TBC/RABGAPs
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000070729 CNGB1 / Q14028 / cyclic nucleotide gated channel beta 1  / reaction / complex
 ENSG00000127328 Q96QF0 / RAB3IP / RAB3A interacting protein  / complex / reaction
 ENSG00000103769 P62491 / RAB11A / RAB11A, member RAS oncogene family  / complex / reaction
 ENSG00000123240 OPTN / Q96CV9 / optineurin  / complex
 ENSG00000090565 O75154 / RAB11FIP3 / RAB11 family interacting protein 3  / reaction / complex
 ENSG00000008710 PKD1 / P98161 / polycystin 1, transient receptor potential channel interacting  / complex / reaction
 ENSG00000163914 RHO / P08100 / rhodopsin  / complex / reaction
 ENSG00000132259 CNGA4 / Q8IV77 / cyclic nucleotide gated channel alpha 4  / complex / reaction
 ENSG00000057608 GDI2 / P50395 / GDP dissociation inhibitor 2  / complex
 ENSG00000203879 GDI1 / P31150 / GDP dissociation inhibitor 1  / complex
 ENSG00000104946 Q9HA65 / TBC1D17 / TBC1 domain family member 17  / complex / reaction
 ENSG00000188419 CHM / P24386 / CHM, Rab escort protein 1  / complex
 ENSG00000183862 CNGA2 / Q16280 / cyclic nucleotide gated channel alpha 2  / complex / reaction
 ENSG00000153317 ASAP1 / Q9ULH1 / ArfGAP with SH3 domain, ankyrin repeat and PH domain 1  / complex / reaction
 ENSG00000203668 CHML / P26374 / CHM like, Rab escort protein 2  / complex
 ENSG00000166851 PLK1 / P53350 / polo like kinase 1  / reaction






 

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