ENSGALG00000028851


Gallus gallus

Features
Gene ID: ENSGALG00000028851
  
Biological name :RAB8A
  
Synonyms : Q5F470 / RAB8A / Ras-related protein Rab-8A
  
Possible biological names infered from orthology : P55258 / P61006 / RAB8A, member RAS oncogene family
  
Species: Gallus gallus
  
Chr. number: 28
Strand: -1
Band:
Gene start: 4438750
Gene end: 4451556
  
Corresponding Affymetrix probe sets: Gga.16249.1.S1_at (Chicken Array)   Gga.16249.2.S1_s_at (Chicken Array)   Gga.3702.1.S1_a_at (Chicken Array)   Gga.5711.1.S1_at (Chicken Array)   GgaAffx.21524.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000041790
Ensembl peptide - ENSGALP00000064197
NCBI entrez gene - 428352     See in Manteia.
RefSeq - NM_001031504
RefSeq Peptide - NP_001026675
swissprot - Q5F470
Ensembl - ENSGALG00000028851
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rab8aENSDARG00000067920Danio rerio
 RAB8AENSG00000167461Homo sapiens
 Rab8aENSMUSG00000003037Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RAB8B / RAB8B, member RAS oncogene family / P61028* / Q92930*ENSGALG0000000348781
RAB10 / ras-related protein Rab-10 / P61026* / P61027* / RAB10, member RAS oncogene family*ENSGALG0000001653568
RAB3C / RAB3C, member RAS oncogene family / P62823* / Q96E17*ENSGALG0000001472649
RAB3A / RAB3A, member RAS oncogene family / P20336* / P63011*ENSGALG0000003006848
RAB12 / RAB12, member RAS oncogene family / P35283* / Q6IQ22* / Ras-related protein Rab-12 *ENSGALG0000003360844
RAB27A / RAB27A, member RAS oncogene family / P51159* / Q9ERI2*ENSGALG0000000443541
RAB3B / RAB3B, member RAS oncogene family / P20337* / Q9CZT8*ENSGALG0000001056738
ENSGALG0000001518338
RASEF / RAS and EF-hand domain containing / Q5RI75* / Q8IZ41* / Ras and EF-hand domain-containing protein homolog *ENSGALG0000001257634
RAB44 / RAB44, member RAS oncogene family / Q8CB87* / Ras-related protein Rab-44 *ENSGALG0000000054433
ENSGALG0000004648832


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006904 vesicle docking involved in exocytosis IBA
 biological_processGO:0007409 axonogenesis ISS
 biological_processGO:0009306 protein secretion IBA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0017157 regulation of exocytosis IBA
 biological_processGO:0072659 protein localization to plasma membrane IBA
 cellular_componentGO:0005768 endosome IBA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0008021 synaptic vesicle IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030667 secretory granule membrane IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005525 GTP binding ISS
 molecular_functionGO:0017137 Rab GTPase binding ISS
 molecular_functionGO:0019003 GDP binding ISS


Pathways (from Reactome)
Pathway description
Regulation of PLK1 Activity at G2/M Transition
Anchoring of the basal body to the plasma membrane
VxPx cargo-targeting to cilium
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000006110 PLK1 / serine/threonine-protein kinase PLK1 / P53350* / Q07832* / polo like kinase 1*  / reaction
 ENSGALG00000005714 PKD1 / polycystin 1, transient receptor potential channel interacting / O08852* / P98161* / Polycystin-1 *  / complex / reaction
 ENSGALG00000007615 Q5ZJN2 / RAB11A / Ras-related protein Rab-11A / P62491* / P62492* / RAB11A, member RAS oncogene family*  / complex / reaction
 ENSGALG00000009959 Q68EF0* / Q96QF0* / RAB3IP* / AC025263.2* / RAB3A interacting protein*  / reaction / complex
 ENSGALG00000037618 ASAP1 / ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 / Q9QWY8* / Q9ULH1* / Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 *  / reaction / complex
 ENSGALG00000013738 OPTN / Q90Z16 / Optineurin / Q8K3K8* / Q96CV9* / Mus musculus optineurin (Optn), transcript variant 1, mRNA.*  / complex






 

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