ENSGALG00000006110


Gallus gallus

Features
Gene ID: ENSGALG00000006110
  
Biological name :PLK1
  
Synonyms : PLK1 / serine/threonine-protein kinase PLK1
  
Possible biological names infered from orthology : P53350 / polo like kinase 1 / Q07832
  
Species: Gallus gallus
  
Chr. number: 14
Strand: 1
Band:
Gene start: 6936437
Gene end: 6941976
  
Corresponding Affymetrix probe sets: GgaAffx.12701.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000009850
Ensembl peptide - ENSGALP00000064482
Ensembl peptide - ENSGALP00000060797
Ensembl peptide - ENSGALP00000058975
NCBI entrez gene - 416575     See in Manteia.
RefSeq - NM_001030639
RefSeq Peptide - NP_001025810
swissprot - A0A1L1S025
swissprot - A0A1L1RPS3
swissprot - A0A1L1RJN9
swissprot - F1NCX7
Ensembl - ENSGALG00000006110
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plk1ENSDARG00000058471Danio rerio
 PLK1ENSG00000166851Homo sapiens
 Plk1ENSMUSG00000030867Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PLK3 / polo like kinase 3 / Q9H4B4* / serine/threonine-protein kinase PLK3 isoform 2 *ENSGALG0000001012939
PLK2 / polo like kinase 2 / P53351* / Q9NYY3* / Serine/threonine-protein kinase PLK2 *ENSGALG0000001472538
PLK4 / polo like kinase 4 / O00444* / Q64702* / Serine/threonine-protein kinase PLK4 *ENSGALG0000001019524


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000959  POLO box domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000070 mitotic sister chromatid segregation IEA
 biological_processGO:0000086 G2/M transition of mitotic cell cycle IEA
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0000281 mitotic cytokinesis IEA
 biological_processGO:0001578 microtubule bundle formation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007094 mitotic spindle assembly checkpoint IEA
 biological_processGO:0007098 centrosome cycle IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IEA
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016321 female meiosis chromosome segregation IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0030071 regulation of mitotic metaphase/anaphase transition IEA
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0032465 regulation of cytokinesis IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043393 regulation of protein binding IEA
 biological_processGO:0045143 homologous chromosome segregation IEA
 biological_processGO:0045184 establishment of protein localization IEA
 biological_processGO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IEA
 biological_processGO:0045862 positive regulation of proteolysis IEA
 biological_processGO:0051081 nuclear envelope disassembly IEA
 biological_processGO:0051443 positive regulation of ubiquitin-protein transferase activity IEA
 biological_processGO:0070194 synaptonemal complex disassembly IEA
 biological_processGO:0071168 protein localization to chromatin IEA
 biological_processGO:0072425 signal transduction involved in G2 DNA damage checkpoint IEA
 biological_processGO:0090435 protein localization to nuclear envelope IEA
 biological_processGO:1901673 regulation of mitotic spindle assembly IEA
 biological_processGO:1904668 positive regulation of ubiquitin protein ligase activity IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000780 condensed nuclear chromosome, centromeric region IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0000795 synaptonemal complex IEA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0000942 condensed nuclear chromosome outer kinetochore IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005876 spindle microtubule IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0051233 spindle midzone IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0010997 anaphase-promoting complex binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Polo-like kinase mediated events
Golgi Cisternae Pericentriolar Stack Reorganization
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Phosphorylation of the APC/C
Phosphorylation of Emi1
Condensation of Prophase Chromosomes
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
RHO GTPases Activate Formins
Mitotic Prometaphase
Mitotic Metaphase/Anaphase Transition
Mitotic Telophase/Cytokinesis
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000016931 BORA / Q6PGQ7* / Q8BS90* / Protein aurora borealis * / bora, aurora kinase A activator*  / reaction / complex
 ENSGALG00000042491 P62801 / Histone H4   / complex / reaction
 ENSGALG00000002085 FZR1 / fizzy-related protein homolog / Q9R1K5* / Q9UM11* / fizzy and cell division cycle 20 related 1*  / reaction
 ENSGALG00000001907 WAPL / wings apart-like protein homolog / Q65Z40* / Q7Z5K2* / WAPL cohesin release factor*  / reaction
 ENSGALG00000009971 CDC20 / cell division cycle 20 / Q12834* / Q9JJ66* / Cell division cycle *  / reaction
 ENSGALG00000035030 KIF20A / kinesin family member 20A / O95235* / P97329* / Kinesin-like protein KIF20A *  / reaction
 ENSGALG00000017070 PDS5B / PDS5 cohesin associated factor B / Q4VA53* / Q9NTI5* / Mus musculus PDS5 cohesin associated factor B (Pds5b), transcript variant 2, mRNA.*  / reaction
 ENSGALG00000005769 WEE1 / wee1-like protein kinase / P47810* / P30291* / WEE1 G2 checkpoint kinase* / WEE 1 homolog 1 (S. pombe)*  / reaction
 ENSGALG00000028851 RAB8A / Q5F470 / Ras-related protein Rab-8A / P61006* / P55258* / RAB8A, member RAS oncogene family*  / reaction
 ENSGALG00000013738 OPTN / Q90Z16 / Optineurin / Q8K3K8* / Q96CV9* / Mus musculus optineurin (Optn), transcript variant 1, mRNA.*  / reaction
 ENSGALG00000007768 AURKA / aurora kinase A / O14965* / P97477*  / complex / reaction
 ENSGALG00000031582 RAB1B / RAB1A, member RAS oncogene family / Rab1* / RAB1A* / P62821* / P62820* / Ras-related protein Rab-1A *  / complex






 

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