ENSGALG00000007768


Gallus gallus

Features
Gene ID: ENSGALG00000007768
  
Biological name :AURKA
  
Synonyms : AURKA / aurora kinase A
  
Possible biological names infered from orthology : O14965 / P97477
  
Species: Gallus gallus
  
Chr. number: 20
Strand: 1
Band:
Gene start: 12229605
Gene end: 12236352
  
Corresponding Affymetrix probe sets: Gga.9936.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000032883
Ensembl peptide - ENSGALP00000064752
Ensembl peptide - ENSGALP00000060931
NCBI entrez gene - 428167     See in Manteia.
RefSeq - XM_015296533
RefSeq - XM_425725
swissprot - E1BVE1
swissprot - A0A1L1S0U4
Ensembl - ENSGALG00000007768
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aurkaENSDARG00000012485Danio rerio
 AURKAENSG00000087586Homo sapiens
 AurkaENSMUSG00000027496Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
STK36 / serine/threonine kinase 36 / Q69ZM6* / Q9NRP7*ENSGALG0000001137121
NEK10* / Q3UGM2* / Q6ZWH5* / NIMA related kinase 10* / Serine/threonine-protein kinase Nek10 *ENSGALG0000004056915
NEK10* / Q3UGM2* / Q6ZWH5* / NIMA related kinase 10* / Serine/threonine-protein kinase Nek10 *ENSGALG000000113225


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR030611  Aurora kinase A
 IPR030616  Aurora kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000212 meiotic spindle organization IEA
 biological_processGO:0000226 microtubule cytoskeleton organization IEA
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007051 spindle organization IEA
 biological_processGO:0007052 mitotic spindle organization IBA
 biological_processGO:0007057 spindle assembly involved in female meiosis I IEA
 biological_processGO:0007098 centrosome cycle IEA
 biological_processGO:0007100 mitotic centrosome separation IEA
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0009948 anterior/posterior axis specification IEA
 biological_processGO:0031647 regulation of protein stability IEA
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0032465 regulation of cytokinesis IBA
 biological_processGO:0035404 histone-serine phosphorylation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0051642 centrosome localization IEA
 biological_processGO:0071539 protein localization to centrosome IEA
 biological_processGO:0097421 liver regeneration IEA
 biological_processGO:1900195 positive regulation of oocyte maturation IEA
 biological_processGO:1990138 neuron projection extension IEA
 cellular_componentGO:0000780 condensed nuclear chromosome, centromeric region IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005876 spindle microtubule IBA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0031616 spindle pole centrosome IBA
 cellular_componentGO:0032133 chromosome passenger complex IBA
 cellular_componentGO:0042585 germinal vesicle IEA
 cellular_componentGO:0043203 axon hillock IEA
 cellular_componentGO:0045120 pronucleus IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0051233 spindle midzone IBA
 cellular_componentGO:0072686 mitotic spindle IEA
 cellular_componentGO:0072687 meiotic spindle IEA
 cellular_componentGO:0097431 mitotic spindle pole IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0035174 histone serine kinase activity IBA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M Transition
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
AURKA Activation by TPX2
Interaction between PHLDA1 and AURKA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000006110 PLK1 / serine/threonine-protein kinase PLK1 / P53350* / Q07832* / polo like kinase 1*  / complex / reaction
 ENSGALG00000006267 TPX2 / targeting protein for Xklp2 / A2APB8* / Q9ULW0* / TPX2, microtubule nucleation factor*  / reaction / complex
 ENSGALG00000006474 SKP1 / Q5ZKF5 / S-phase kinase-associated protein 1 / Skp1a* / Q9WTX5* / P63208* / AC104109.3* / S-phase kinase-associated protein 1A*  / complex / reaction
 ENSGALG00000016931 BORA / Q6PGQ7* / Q8BS90* / Protein aurora borealis * / bora, aurora kinase A activator*  / complex / reaction
 ENSGALG00000025977 GADD45A / growth arrest and DNA damage inducible alpha / P24522* / P48316* / Growth arrest and DNA damage-inducible protein GADD45 alpha *  / reaction / complex
 ENSGALG00000042009 HMMR / hyaluronan mediated motility receptor / O75330* / Q00547*  / reaction / complex
 ENSGALG00000011993 RBX1 / ring-box 1 / P62877* / P62878* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / reaction / complex
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000036941 CUL1 / cullin 1 / Q13616* / Q9WTX6* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*  / reaction / complex
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction






 

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