ENSDARG00000012485


Danio rerio

Features
Gene ID: ENSDARG00000012485
  
Biological name :aurka
  
Synonyms : aurka / aurora kinase A
  
Possible biological names infered from orthology : O14965 / P97477
  
Species: Danio rerio
  
Chr. number: 6
Strand: 1
Band:
Gene start: 60125033
Gene end: 60139655
  
Corresponding Affymetrix probe sets: Dr.2110.1.A1_at (Zebrafish Array)   NM_001003640_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000124145
Ensembl peptide - ENSDARP00000021253
NCBI entrez gene - 445246     See in Manteia.
RefSeq - NM_001003640
RefSeq Peptide - NP_001003640
swissprot - F8W4T4
swissprot - F1QEM3
ZFIN ID - ZDB-GENE-040801-161
Ensembl - ENSDARG00000012485
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AURKAENSGALG00000007768Gallus gallus
 AURKAENSG00000087586Homo sapiens
 AurkaENSMUSG00000027496Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
aurkb / aurora kinase B / AURKC* / Q9UQB9* / Q96GD4* / aurora kinase C*ENSDARG0000003764048
nek10 / NIMA-related kinase 10 / Q3UGM2* / Q6ZWH5* / Serine/threonine-protein kinase Nek10 *ENSDARG0000002533523
stk36 / serine/threonine kinase 36 (fused homolog, Drosophila) / Q69ZM6* / Q9NRP7* / serine/threonine kinase 36*ENSDARG0000006109521


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR030611  Aurora kinase A
 IPR030616  Aurora kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000212 meiotic spindle organization IEA
 biological_processGO:0000226 microtubule cytoskeleton organization IEA
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007052 mitotic spindle organization IBA
 biological_processGO:0007098 centrosome cycle IEA
 biological_processGO:0007100 mitotic centrosome separation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0032465 regulation of cytokinesis IBA
 biological_processGO:0035404 histone-serine phosphorylation IEA
 biological_processGO:0051321 meiotic cell cycle IEA
 cellular_componentGO:0000780 condensed nuclear chromosome, centromeric region IBA
 cellular_componentGO:0005876 spindle microtubule IBA
 cellular_componentGO:0031616 spindle pole centrosome IBA
 cellular_componentGO:0032133 chromosome passenger complex IBA
 cellular_componentGO:0051233 spindle midzone IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0035174 histone serine kinase activity IBA


Pathways (from Reactome)
Pathway description
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M Transition
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Regulation of TP53 Activity through Phosphorylation
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
AURKA Activation by TPX2
Interaction between PHLDA1 and AURKA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain decreased size , abnormal
brain malformed , abnormal
brain immature , abnormal
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 ZFA:0000098 proliferative region proliferative region intrinsic apoptotic signaling pathway by p53 class mediator increased occurrence , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000155 somite somite decreased width , abnormal
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 ZFA:0000570 optic primordium optic primordium immature , abnormal
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 ZFA:0001058 caudal fin caudal fin intrinsic apoptotic signaling pathway by p53 class mediator increased occurrence , abnormal
caudal fin shortened , abnormal
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 ZFA:0001094 whole organism whole organism intrinsic apoptotic signaling pathway by p53 class mediator increased occurrence , abnormal
whole organism decreased life span , abnormal
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 ZFA:0001114 head head intrinsic apoptotic signaling pathway by p53 class mediator increased occurrence , abnormal
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 ZFA:0001115 trunk trunk intrinsic apoptotic signaling pathway by p53 class mediator increased occurrence , abnormal
trunk bent , abnormal
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 ZFA:0009000 cell cell spindle disorganized , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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