ENSDARG00000037640


Danio rerio

Features
Gene ID: ENSDARG00000037640
  
Biological name :aurkb
  
Synonyms : aurkb / aurora kinase B
  
Possible biological names infered from orthology : AURKC / aurora kinase C / O70126 / Q96GD4 / Q9UQB9
  
Species: Danio rerio
  
Chr. number: 14
Strand: -1
Band:
Gene start: 240487
Gene end: 246342
  
Corresponding Affymetrix probe sets: Dr.8332.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000054822
NCBI entrez gene - 791894     See in Manteia.
swissprot - F1RDC1
ZFIN ID - ZDB-GENE-020419-40
Ensembl - ENSDARG00000037640
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AURKBENSG00000178999Homo sapiens
 AURKCENSG00000105146Homo sapiens
 AurkbENSMUSG00000020897Mus musculus
 AurkcENSMUSG00000070837Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
aurka / aurora kinase A / O14965* / P97477*ENSDARG0000001248561
stk36 / serine/threonine kinase 36 (fused homolog, Drosophila) / Q69ZM6* / Q9NRP7* / serine/threonine kinase 36*ENSDARG0000006109528
nek10 / NIMA-related kinase 10 / Q3UGM2* / Q6ZWH5* / Serine/threonine-protein kinase Nek10 *ENSDARG0000002533525


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR028772  Aurora kinase B
 IPR030616  Aurora kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Regulation of TP53 Activity through Phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain necrotic , abnormal
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 ZFA:0000012 central nervous system central nervous system necrotic , abnormal
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 ZFA:0000076 swim bladder swim bladder collapsed , abnormal
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 ZFA:0000093 blastomere blastomere germ plasm mislocalised , abnormal
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 ZFA:0000396 nervous system nervous system quality , abnormal
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 ZFA:0000547 mouth mouth protruding , abnormal
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 ZFA:0001094 whole organism whole organism viability , abnormal
whole organism necrotic , abnormal
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 ZFA:0001114 head head flat , abnormal
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 ZFA:0001176 blastoderm blastoderm morphology , abnormal
blastoderm cleavage furrow absent , abnormal
blastoderm cleavage furrow decreased length , abnormal
blastoderm cleavage furrow malformed , abnormal
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 ZFA:0009000 cell cell nucleus condensed , abnormal
cell midbody decreased mass density , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000035559 tp53 / P79734 / tumor protein p53 / Trp53* / P04637* / P02340* / transformation related protein 53*  / complex / reaction
 ENSDARG00000043137 cdca8 / cell division cycle associated 8 / Q53HL2*  / complex
 ENSDARG00000001754 noc2l / NOC2-like nucleolar associated transcriptional repressor / Q9Y3T9*  / reaction / complex






 

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