ENSMUSG00000070837


Mus musculus

Features
Gene ID: ENSMUSG00000070837
  
Biological name :Aurkc
  
Synonyms : Aurkc
  
Possible biological names infered from orthology : aurora kinase C / Q9UQB9
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A1
Gene start: 6995300
Gene end: 7003091
  
Corresponding Affymetrix probe sets: 10512680 (MoGene1.0st)   10549889 (MoGene1.0st)   10559989 (MoGene1.0st)   10560004 (MoGene1.0st)   1449364_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147207
Ensembl peptide - ENSMUSP00000146450
Ensembl peptide - ENSMUSP00000146898
Ensembl peptide - ENSMUSP00000147055
Ensembl peptide - ENSMUSP00000083426
NCBI entrez gene - 20871     See in Manteia.
MGI - MGI:1321119
RefSeq - XM_017322081
RefSeq - NM_001080966
RefSeq - NM_020572
RefSeq - XM_006539697
RefSeq - XM_006539701
RefSeq - XM_011250466
RefSeq - XM_017322079
RefSeq - XM_017322080
RefSeq - NM_001080965
RefSeq Peptide - NP_065597
RefSeq Peptide - NP_001074434
RefSeq Peptide - NP_001074435
swissprot - A0A140LIP1
swissprot - Q6P209
swissprot - A0A140LJ30
swissprot - E9QL04
Ensembl - ENSMUSG00000070837
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aurkbENSDARG00000037640Danio rerio
 AURKCENSG00000105146Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Aurkb / O70126 / Aurora kinase B / Q96GD4*ENSMUSG0000002089768
Aurka / P97477 / Aurora kinase A / O14965*ENSMUSG0000002749659
Stk36 / Q69ZM6 / serine/threonine kinase 36 / Q9NRP7*ENSMUSG0000003327628
Nek10 / Q3UGM2 / Serine/threonine-protein kinase Nek10 / Q6ZWH5* / NIMA related kinase 10*ENSMUSG0000004256725


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR030613  Aurora kinase C
 IPR030616  Aurora kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000910 cytokinesis IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0048599 oocyte development IEA
 biological_processGO:0051255 spindle midzone assembly IEA
 biological_processGO:0051321 meiotic cell cycle IEA
 cellular_componentGO:0032133 chromosome passenger complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hesx1tm1Icar/Hesx1tm3Jpmb
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB/N

 MP:0008898 abnormal acrosome morphology "any structural anomaly of the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration" [MESH:A05.360.490.890.820.100]
Show

Allelic Composition: Hesx1tm1Icar/Hesx1tm3Jpmb
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB/N

 MP:0009230 abnormal sperm head morphology "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hesx1tm1Icar/Hesx1tm3Jpmb
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB/N

 MP:0009231 detached acrosome "detachment or loss of adhesion of the acrosome cap from the sperm head nucleus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hesx1tm1Icar/Hesx1tm3Jpmb
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB/N

 MP:0009232 abnormal sperm nucleus morphology "any structural abnormality of the sperm head nucleus, including an abnormal nuclear shape or defects in the compaction of nuclear chromatin" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hesx1tm1Icar/Hesx1tm3Jpmb
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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