ENSMUSG00000033276


Mus musculus

Features
Gene ID: ENSMUSG00000033276
  
Biological name :Stk36
  
Synonyms : Q69ZM6 / serine/threonine kinase 36 / Stk36
  
Possible biological names infered from orthology : Q9NRP7
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C3
Gene start: 74601445
Gene end: 74636894
  
Corresponding Affymetrix probe sets: 10347427 (MoGene1.0st)   1434733_at (Mouse Genome 430 2.0 Array)   1453584_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000109324
Ensembl peptide - ENSMUSP00000140912
Ensembl peptide - ENSMUSP00000120020
Ensembl peptide - ENSMUSP00000084430
Ensembl peptide - ENSMUSP00000084433
NCBI entrez gene - 269209     See in Manteia.
MGI - MGI:1920831
RefSeq - NM_175031
RefSeq - XM_006496039
RefSeq Peptide - NP_778196
swissprot - E9Q341
swissprot - Q69ZM6
swissprot - Q9D9B2
swissprot - A0A087WS61
Ensembl - ENSMUSG00000033276
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stk36ENSDARG00000061095Danio rerio
 STK36ENSGALG00000011371Gallus gallus
 STK36ENSG00000163482Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nek10 / Q3UGM2 / Serine/threonine-protein kinase Nek10 / Q6ZWH5* / NIMA related kinase 10*ENSMUSG0000004256711
Aurkb / O70126 / Aurora kinase B / Q96GD4*ENSMUSG000000208977
Aurka / P97477 / Aurora kinase A / O14965*ENSMUSG000000274967
Aurkc / Q9UQB9* / aurora kinase C*ENSMUSG000000708377


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003351 epithelial cilium movement IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007228 positive regulation of hh target transcription factor activity IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007420 brain development IMP
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0045880 positive regulation of smoothened signaling pathway IDA
 biological_processGO:0051090 regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0060271 cilium assembly IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoftm1(KOMP)Vlcg/Apof+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Alms1L2131X/Alms1L2131X
Genetic Background: involves: C57BL/6 * NOD

 MP:0000440 domed skull 
Show

Allelic Composition: Alms1L2131X/Alms1L2131X
Genetic Background: involves: C57BL/6 * NOD

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Alms1L2131X/Alms1L2131X
Genetic Background: involves: C57BL/6 * NOD

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Alms1L2131X/Alms1L2131X
Genetic Background: involves: C57BL/6 * NOD

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoftm1(KOMP)Vlcg/Apof+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Hfetm1.1Wsr/Hfetm1.1Wsr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Stk36tm1Lex/Stk36tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Alms1L2131X/Alms1L2131X
Genetic Background: involves: C57BL/6 * NOD

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Alms1L2131X/Alms1L2131X
Genetic Background: involves: C57BL/6 * NOD

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Alms1L2131X/Alms1L2131X
Genetic Background: involves: C57BL/6 * NOD

Allelic Composition: Stk36tm1.1Ptch/Stk36tm1.1Ptch
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * Swiss Webster

Allelic Composition: Stk36tm1Lex/Stk36tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001850 otitis media "middle ear inflammation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]
Show

Allelic Composition: Stk36tm1Lex/Stk36tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001867 rhinitis "inflammation of the mucous membrane of the nose" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Alms1L2131X/Alms1L2131X
Genetic Background: involves: C57BL/6 * NOD

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Stk36tm1Lex/Stk36tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001893 non-obstructive hydrocephaly "abnormal cerebrospinal fluid absorption where there is no obstruction to fluid flow in the ventricular system" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Alms1L2131X/Alms1L2131X
Genetic Background: involves: C57BL/6 * NOD

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Alms1L2131X/Alms1L2131X
Genetic Background: involves: C57BL/6 * NOD

Allelic Composition: Stk36tm1Ptch/Stk36tm1Ptch,Tg(Ddx4-cre)1Ptch/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Stk36tm1Lex/Stk36tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoftm1(KOMP)Vlcg/Apof+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0002673 abnormal sperm count "increased or decreased numbers of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Stk36tm1Ptch/Stk36tm1Ptch,Tg(Ddx4-cre)1Ptch/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0003643 spleen atrophy "wasting of the spleen resulting in reduced size" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Alms1L2131X/Alms1L2131X
Genetic Background: involves: C57BL/6 * NOD

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Alms1L2131X/Alms1L2131X
Genetic Background: involves: C57BL/6 * NOD

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Smarcd2tm1.1(KOMP)Vlcg/Smarcd2+
Genetic Background: C57BL/6N-Smarcd2tm1.1(KOMP)Vlcg/Ucd

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stk36tm1Ptch/Stk36tm1Ptch,Tg(Ddx4-cre)1Ptch/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0008892 abnormal sperm flagellum "any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]
Show

Allelic Composition: Stk36tm1Ptch/Stk36tm1Ptch,Tg(Ddx4-cre)1Ptch/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0009230 abnormal sperm head morphology "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stk36tm1Ptch/Stk36tm1Ptch,Tg(Ddx4-cre)1Ptch/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0009232 abnormal sperm nucleus morphology "any structural abnormality of the sperm head nucleus, including an abnormal nuclear shape or defects in the compaction of nuclear chromatin" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stk36tm1Ptch/Stk36tm1Ptch,Tg(Ddx4-cre)1Ptch/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0009234 absent sperm head "absence of the head segment of the sperm cell" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stk36tm1Ptch/Stk36tm1Ptch,Tg(Ddx4-cre)1Ptch/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0009280 reduced activated sperm motility "loss or reduction of the activated type of sperm mobility, resulting in immotile sperm that are generally unable to reach the uterotubal junction; decreases in activated sperm motility may result in reduced male fertility" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stk36tm1Ptch/Stk36tm1Ptch,Tg(Ddx4-cre)1Ptch/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0009376 abnormal manchette morphology "any structural abnormality of the conic array of microtubules that invests the posterior nucleus of a spermatid, and is believed to play a role in definitive posterior head-shaping events during spermiogenesis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stk36tm1Ptch/Stk36tm1Ptch,Tg(Ddx4-cre)1Ptch/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0009836 abnormal sperm principal piece morphology "any structural abnormality in the segment of the sperm flagellum where the mitochondrial sheath ends and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs; the principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece" [PMID:14581499]
Show

Allelic Composition: Stk36tm1Ptch/Stk36tm1Ptch,Tg(Ddx4-cre)1Ptch/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0009838 abnormal sperm axoneme morphology "any structural abnormality of the central core of the sperm flagellum, composed of a ring of 9 outer microtubule doublets surrounding a central pair; inner and outer dynein arms project from each of the outer 9 doublets, and these arms are responsible for generating the motive force of the flagellum; in addition, 9 radial spokes, each of which originates from 1 of the 9 outer microtubular doublet pairs, project inward toward the central pair in a helical fashion" [PMID:14581499]
Show

Allelic Composition: Stk36tm1Ptch/Stk36tm1Ptch,Tg(Ddx4-cre)1Ptch/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Alms1L2131X/Alms1L2131X
Genetic Background: involves: C57BL/6 * NOD

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Stk36tm1.1Ptch/Stk36tm1.1Ptch
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * Swiss Webster

 MP:0020451 decreased sperm progressive motility "decrease in the ability of sperm to move in a more or less straight line" [MGI:smb]
Show

Allelic Composition: Stk36tm1Ptch/Stk36tm1Ptch,Tg(Ddx4-cre)1Ptch/0
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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