ENSMUSG00000027496


Mus musculus

Features
Gene ID: ENSMUSG00000027496
  
Biological name :Aurka
  
Synonyms : Aurka / Aurora kinase A / P97477
  
Possible biological names infered from orthology : O14965
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H3
Gene start: 172356190
Gene end: 172370535
  
Corresponding Affymetrix probe sets: 10490104 (MoGene1.0st)   1424511_at (Mouse Genome 430 2.0 Array)   1440129_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028997
Ensembl peptide - ENSMUSP00000104767
Ensembl peptide - ENSMUSP00000104768
NCBI entrez gene - 20878     See in Manteia.
MGI - MGI:894678
RefSeq - XM_006499075
RefSeq - NM_001291185
RefSeq - NM_011497
RefSeq Peptide - NP_035627
RefSeq Peptide - NP_001278114
swissprot - P97477
swissprot - Q3TEY6
Ensembl - ENSMUSG00000027496
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aurkaENSDARG00000012485Danio rerio
 AURKAENSGALG00000007768Gallus gallus
 AURKAENSG00000087586Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Aurkb / O70126 / Aurora kinase B / Q96GD4*ENSMUSG0000002089749
Aurkc / Q9UQB9* / aurora kinase C*ENSMUSG0000007083745
Nek10 / Q3UGM2 / Serine/threonine-protein kinase Nek10 / Q6ZWH5* / NIMA related kinase 10*ENSMUSG0000004256726
Stk36 / Q69ZM6 / serine/threonine kinase 36 / Q9NRP7*ENSMUSG0000003327621


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR030611  Aurora kinase A
 IPR030616  Aurora kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000212 meiotic spindle organization IMP
 biological_processGO:0000226 microtubule cytoskeleton organization IGI
 biological_processGO:0000278 mitotic cell cycle IMP
 biological_processGO:0006468 protein phosphorylation ISO
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007051 spindle organization IEA
 biological_processGO:0007052 mitotic spindle organization IMP
 biological_processGO:0007057 spindle assembly involved in female meiosis I IMP
 biological_processGO:0007098 centrosome cycle IGI
 biological_processGO:0007100 mitotic centrosome separation IMP
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0009948 anterior/posterior axis specification IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0031647 regulation of protein stability IEA
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0032465 regulation of cytokinesis IBA
 biological_processGO:0035404 histone-serine phosphorylation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051321 meiotic cell cycle IMP
 biological_processGO:0051642 centrosome localization IMP
 biological_processGO:0071539 protein localization to centrosome IMP
 biological_processGO:0097421 liver regeneration IEA
 biological_processGO:1900195 positive regulation of oocyte maturation IMP
 biological_processGO:1990138 neuron projection extension IGI
 cellular_componentGO:0000780 condensed nuclear chromosome, centromeric region IBA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0005815 microtubule organizing center IGI
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005876 spindle microtubule IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0031616 spindle pole centrosome IEA
 cellular_componentGO:0032133 chromosome passenger complex IBA
 cellular_componentGO:0042585 germinal vesicle IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043203 axon hillock IDA
 cellular_componentGO:0045120 pronucleus IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0051233 spindle midzone IBA
 cellular_componentGO:0072686 mitotic spindle IDA
 cellular_componentGO:0072687 meiotic spindle IDA
 cellular_componentGO:0097431 mitotic spindle pole IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity ISS
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0035174 histone serine kinase activity IMP
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M Transition
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Regulation of TP53 Activity through Phosphorylation
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
AURKA Activation by TPX2
Interaction between PHLDA1 and AURKA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Aurkatm1.1Tvd/Aurkatm1.1Tvd,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1Sor
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Mad2l1tm2Sorg/Mad2l1tm2Sorg,Tg(KRT14-cre)1Amc/?
Genetic Background: Not Specified

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Tmed299J/Tmed2Gt(PST809)Mfgc
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ * C57BL/6J

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: AurkaGt(XQ0149)Wtsi/AurkaGt(XQ0149)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Aspatm1b(EUCOMM)Wtsi/Aspatm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Aspatm1b(EUCOMM)Wtsi/Ieg

 MP:0002718 abnormal inner cell mass "malformed or absent cells of the blastocyst that develop into the body of the embryo" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mad2l1tm2Sorg/Mad2l1tm2Sorg,Tg(KRT14-cre)1Amc/?
Genetic Background: Not Specified

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Aurkatm1.1Tvd/Aurkatm1.1Tvd,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1Sor
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Aurkatm1.2Sbsn/Aurkatm1.2Sbsn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003694 failure to hatch from the zona pellucida "the embryo fails to break out of the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation, may be seen in vivo or in cultured embryos" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Aurkatm1.1Tvd/Aurkatm1.1Tvd,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aurkatm1.2Sbsn/Aurkatm1.2Sbsn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004023 abnormal chromosome number "chromosome count is other than the expected diploid chromosome number" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aurkatm1.1Tvd/Aurkatm1.1Tvd,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1Sor
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: AurkaGt(XQ0149)Wtsi/AurkaGt(XQ0149)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Aurkatm1.1Tvd/Aurkatm1.1Tvd,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1Sor
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Aurkatm1.1Tvd/Aurkatm1.1Tvd,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6J

Allelic Composition: AurkaGt(XQ0149)Wtsi/AurkaGt(XQ0149)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Aurkatm1.2Sbsn/Aurkatm1.2Sbsn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004207 squamous cell carcinoma "a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: AurkaGt(XQ0149)Wtsi/AurkaGt(XQ0149)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004760 increased mitotic index "increased number of cells in G2/M phase" [Bertram_Weiss:Bayer_Schering_Pharma_AG]
Show

Allelic Composition: Aurkatm1.1Tvd/Aurkatm1.1Tvd,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1Sor
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Aurkatm1.1Tvd/Aurkatm1.1Tvd,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6J

Allelic Composition: Aurkatm1.2Tvd/Aurkatm1.2Tvd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004965 inner cell mass degeneration 
Show

Allelic Composition: Aurkatm1.2Sbsn/Aurkatm1.2Sbsn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Aspatm1b(EUCOMM)Wtsi/Aspatm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Aspatm1b(EUCOMM)Wtsi/Ieg

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Aurkatm1.1Tvd/Aurkatm1.1Tvd,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1Sor
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

 MP:0006204 embryonic lethality before implantation "death anytime after fertilization but before implantation (E0 to less than E4.5)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tmed299J/Tmed2Gt(PST809)Mfgc
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ * C57BL/6J

 MP:0008714 lung carcinoma "a malignant neoplasm of the ling, arising from epithelial cells, usually glandular or squamous" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: AurkaGt(XQ0149)Wtsi/AurkaGt(XQ0149)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
Show

Allelic Composition: AurkaGt(XQ0149)Wtsi/AurkaGt(XQ0149)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009760 abnormal mitotic spindle "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]
Show

Allelic Composition: Aurkatm1.2Tvd/Aurkatm1.2Tvd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: AurkaGt(XQ0149)Wtsi/AurkaGt(XQ0149)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Aurkatm1.2Sbsn/Aurkatm1.2Sbsn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009781 abnormal preimplantation embryo development "an anomaly in the developmental progress of an embryo from 2 cell to blastocyst affecting the viability or number of embryos" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aurkatm1.2Tvd/Aurkatm1.2Tvd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010264 increased hepatoma incidence "greater than the expected number of malignant tumors composed of neoplastic liver cells in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: AurkaGt(XQ0149)Wtsi/AurkaGt(XQ0149)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Aurkatm1.2Sbsn/Aurkatm1.2Sbsn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Aurkatm1.2Tvd/Aurkatm1.2Tvd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: AurkaGt(XQ0149)Wtsi/AurkaGt(XQ0149)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020330 Hmmr / Q00547 / Hyaluronan mediated motility receptor / O75330*  / complex / reaction
 ENSMUSG00000022070 Bora / Q8BS90 / Protein aurora borealis / Q6PGQ7* / bora, aurora kinase A activator*  / complex / reaction
 ENSMUSG00000030867 Plk1 / Q07832 / polo like kinase 1 / P53350*  / reaction / complex
 ENSMUSG00000027469 Tpx2 / A2APB8 / Targeting protein for Xklp2 / Q9ULW0* / TPX2, microtubule nucleation factor*  / reaction / complex
 ENSMUSG00000043556 Fbxl7 / Q5BJ29 / F-box/LRR-repeat protein 7 / Q9UJT9* / F-box and leucine rich repeat protein 7*  / reaction / complex
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / reaction
 ENSMUSG00000036309 Skp1a / Q9WTX5 / S-phase kinase-associated protein 1A / SKP1* / P63208* / AC104109.3* / S-phase kinase associated protein 1*  / reaction / complex
 ENSMUSG00000036390 P48316 / Gadd45a / Growth arrest and DNA damage-inducible protein GADD45 alpha / P24522* / growth arrest and DNA damage inducible alpha*  / complex / reaction
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / reaction / complex
 ENSMUSG00000029686 Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*  / complex / reaction
 ENSMUSG00000022178 Ajuba / Q91XC0 / LIM domain-containing protein ajuba / Q96IF1* / ajuba LIM protein*  / reaction / complex
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex
 ENSMUSG00000020205 Phlda1 / Q62392 / Pleckstrin homology-like domain family A member 1 / Q8WV24*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr