ENSMUSG00000036390


Mus musculus

Features
Gene ID: ENSMUSG00000036390
  
Biological name :Gadd45a
  
Synonyms : Gadd45a / Growth arrest and DNA damage-inducible protein GADD45 alpha / P48316
  
Possible biological names infered from orthology : growth arrest and DNA damage inducible alpha / P24522
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: C1
Gene start: 67035096
Gene end: 67037457
  
Corresponding Affymetrix probe sets: 10545130 (MoGene1.0st)   1449519_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000044034
Ensembl peptide - ENSMUSP00000145432
Ensembl peptide - ENSMUSP00000145136
NCBI entrez gene - 13197     See in Manteia.
MGI - MGI:107799
RefSeq - NM_007836
RefSeq Peptide - NP_031862
swissprot - A0A0N4SVJ9
swissprot - A0A0N4SW99
swissprot - P48316
swissprot - Q3UMH6
Ensembl - ENSMUSG00000036390
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gadd45aaENSDARG00000043581Danio rerio
 gadd45abENSDARG00000104571Danio rerio
 GADD45AENSGALG00000025977Gallus gallus
 P24522ENSG00000116717Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P22339 / Gadd45b / Growth arrest and DNA damage-inducible protein GADD45 beta / O75293* / growth arrest and DNA damage inducible beta*ENSMUSG0000001531254
Gadd45g / growth arrest and DNA damage inducible gamma / O95257*ENSMUSG0000002145353


Protein motifs (from Interpro)
Interpro ID Name
 IPR004038  Ribosomal protein L7Ae/L30e/S12e/Gadd45
 IPR024824  Growth arrest and DNA damage-inducible protein GADD45
 IPR029064  50S ribosomal protein L30e-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000185 activation of MAPKKK activity IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IDA
 biological_processGO:0006950 response to stress IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007098 centrosome cycle IGI
 biological_processGO:0042770 signal transduction in response to DNA damage IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071479 cellular response to ionizing radiation IEA
 biological_processGO:0071850 mitotic cell cycle arrest IEA
 biological_processGO:1900745 positive regulation of p38MAPK cascade IEA
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA


Pathways (from Reactome)
Pathway description
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aqp2tm1Bxy/Aqp2tm1Bxy,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB

 MP:0000714 increased thymocyte number "greater than expected number of precursors to T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * C57BL/6

 MP:0001203 skin irradiation sensitivity "increased incidence of aberrant or damaged cells due to irradiation induced genotoxic damage" [J:65162]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0001204 skin irradiation resistance "decreased incidence of aberrant or damaged cells due to irradiation induced genotoxic damage" [J:65162]
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001272 increased metastatic potential 
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Allelic Composition: Gadd45atm1Ajf/Gadd45atm1Ajf,Xpctm1Ecf/Xpctm1Ecf
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129X1/SvJ * C57BL/6)

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Gadd45atm1Ajf/Gadd45atm1Ajf,Xpctm1Ecf/Xpctm1Ecf
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129X1/SvJ * C57BL/6)

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
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Allelic Composition: Gadd45atm1Ajf/Gadd45atm1Ajf,Xpctm1Ecf/Xpctm1Ecf
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129X1/SvJ * C57BL/6)

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

Allelic Composition: Gadd45atm1Ajf/Gadd45atm1Ajf,Xpctm1Ecf/Xpctm1Ecf
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129X1/SvJ * C57BL/6)

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0002607 decreased basophil count "lower than average number of basophils as measured by the percent of the total number of leukocytes" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, MPD:Mouse Phenome Database]
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003702 abnormal chromosome morphology "anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * C57BL/6

 MP:0004023 abnormal chromosome number "chromosome count is other than the expected diploid chromosome number" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * C57BL/6

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004500 increased incidence of ionizing radiation-induced tumors "higher than normal frequency of tumor incidence induced by radiation in which the individual particle or photon carries sufficient energy to completely remove an electron from its orbit; common types of this radiation include gamma-rays and X-rays" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004501 increased incidence of UV-induced tumors "higher than normal frequency of tumor incidence induced by exposure to ultraviolet light" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0004759 decreased mitotic index "decreased number of cells in G2/M phase" [Bertram_Weiss:Bayer_Schering_Pharma_AG]
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0004771 increased anti-single stranded DNA antibody level "increase in the level of antibodies that recognize single stranded DNA" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0004796 increased anti-histone antibody level "elevated level of antibodies to histones present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0004955 increased thymus weight "greater than average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Gadd45atm1Ajf/Gadd45atm1Ajf,Xpctm1Ecf/Xpctm1Ecf
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129X1/SvJ * C57BL/6)

 MP:0008411 decreased cellular sensitivity to ultraviolet irradiation "reduced incidence of cell death following exposure to ultraviolet irradiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0009050 dilated proximal convoluted tubules "stretched or widened aperture of the luminal space of the convoluted portion of the duct system of the nephron that extends from the renal glomerular capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0009796 abnormal base-excision repair "any anomaly in the process whereby an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate; the small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase" [GO:0006284]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * C57BL/6

 MP:0011427 mesangial cell hyperplasia "increased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna]
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0011440 increased kidney cell proliferation "increase in the expansion rate of any kidney cell population by cell division" [MGI:anna]
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0011453 abnormal glomerular capillary endothelium morphology "any structural anomaly of the thin, extremely flattened layer of cells that line the interior surface of glomerular capillaries and is densely perforated by large transcellular pores (aka fenestrae or fenestrations) that, unlike those of other fenestrated capillaries, are generally thought to lack diaphragms" [MGI:anna]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0011512 mesangial cell interposition "spreading of mesangial cells into the contiguous space between the adjacent glomerular endothelial cells and the glomerular basement membrane (GBM)" [MGI:anna]
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0011703 increased fibroblast proliferation "greater the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0012010 parturition failure "the process of labor and delivery in female animals does not initiate or complete" [MGI:csmith]
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027496 Aurka / P97477 / Aurora kinase A / O14965*  / complex / reaction
 ENSMUSG00000027342 Pcna / P17918 / proliferating cell nuclear antigen / P12004*  / reaction / complex






 

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