ENSMUSG00000021453


Mus musculus

Features
Gene ID: ENSMUSG00000021453
  
Biological name :Gadd45g
  
Synonyms : Gadd45g / growth arrest and DNA damage inducible gamma
  
Possible biological names infered from orthology : O95257
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A5
Gene start: 51846678
Gene end: 51848468
  
Corresponding Affymetrix probe sets: 10405211 (MoGene1.0st)   1453851_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021903
NCBI entrez gene - 23882     See in Manteia.
MGI - MGI:1346325
RefSeq - NM_011817
RefSeq Peptide - NP_035947
swissprot - Q9R0S0
Ensembl - ENSMUSG00000021453
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BX530077.1ENSDARG00000113103Danio rerio
 gadd45gaENSDARG00000019417Danio rerio
 gadd45gb.1ENSDARG00000016725Danio rerio
 GADD45GENSGALG00000028005Gallus gallus
 O95257ENSG00000130222Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P48316 / Gadd45a / Growth arrest and DNA damage-inducible protein GADD45 alpha / P24522* / growth arrest and DNA damage inducible alpha*ENSMUSG0000003639055
P22339 / Gadd45b / Growth arrest and DNA damage-inducible protein GADD45 beta / O75293* / growth arrest and DNA damage inducible beta*ENSMUSG0000001531253


Protein motifs (from Interpro)
Interpro ID Name
 IPR004038  Ribosomal protein L7Ae/L30e/S12e/Gadd45
 IPR024824  Growth arrest and DNA damage-inducible protein GADD45
 IPR029064  50S ribosomal protein L30e-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000185 activation of MAPKKK activity IEA
 biological_processGO:0006950 response to stress IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:1900745 positive regulation of p38MAPK cascade IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aqp2tm1Bxy/Aqp2tm1Bxy,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Gadd45btm1Flv/Gadd45btm1Flv,Gadd45gtm1Flv/Gadd45gtm1Flv
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Bcl6tm1.1Mtto/Bcl6tm1.1Mtto,Cd79atm1(cre)Reth/Cd79a+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6JJcl * DBA/2

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Gadd45gtm1Jni/Gadd45gtm1Jni
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Bcl6tm1.1Mtto/Bcl6tm1.1Mtto,Cd79atm1(cre)Reth/Cd79a+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6JJcl * DBA/2

Allelic Composition: Gadd45gtm1Jni/Gadd45gtm1Jni
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001939 secondary sex reversal "secondary sexual phenotype is not consistent with the chromosomal sex, i.e., internal and/or external genitalia are inconsistent with chromosomal sex " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl6tm1.1Mtto/Bcl6tm1.1Mtto,Cd79atm1(cre)Reth/Cd79a+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6JJcl * DBA/2

Allelic Composition: Gadd45gtm1Jni/Gadd45gtm1Jni
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002016 ovarian cysts "cystic ovary; usually refers to a benign growth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Gadd45gtm1Jni/Gadd45gtm1Jni
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gadd45btm1Flv/Gadd45btm1Flv,Gadd45gtm1Flv/Gadd45gtm1Flv
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

 MP:0002534 type IV hypersensitivity reaction "an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact " [Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Kmt2atm1Sjk/Kmt2atm1.2Erns
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gadd45btm1Flv/Gadd45btm1Flv,Gadd45gtm1Flv/Gadd45gtm1Flv
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

 MP:0002995 primary sex reversal "gonad type is not consistent with chromosomal sex" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bcl6tm1.1Mtto/Bcl6tm1.1Mtto,Cd79atm1(cre)Reth/Cd79a+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6JJcl * DBA/2

Allelic Composition: Gadd45gtm1Jni/Gadd45gtm1Jni
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Gadd45gtm1Jni/Gadd45g+,X/SryAKR/J
Genetic Background: involves: 129P2/OlaHsd * AKR/J * C57BL/6J

 MP:0002996 ovotestis "gonad with both ovarian and testicular tissue" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Gadd45gtm1Jni/Gadd45g+,Map3k4tm1Flv/Map3k4+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0003830 abnormal testis development "abnormal morphogenesis of the male reproductive gland containing the germ cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:100020]
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Allelic Composition: Bcl6tm1.1Mtto/Bcl6tm1.1Mtto,Cd79atm1(cre)Reth/Cd79a+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6JJcl * DBA/2

Allelic Composition: Gadd45gtm1Jni/Gadd45gtm1Jni
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Gadd45gtm1Jni/Gadd45g+,Map3k4tm1Flv/Map3k4+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Gadd45gtm1Jni/Gadd45g+,X/SryAKR/J
Genetic Background: involves: 129P2/OlaHsd * AKR/J * C57BL/6J

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gadd45btm1Flv/Gadd45btm1Flv,Gadd45gtm1Flv/Gadd45gtm1Flv
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

 MP:0004796 increased anti-histone antibody level "elevated level of antibodies to histones present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gadd45btm1Flv/Gadd45btm1Flv,Gadd45gtm1Flv/Gadd45gtm1Flv
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Kmt2atm1Sjk/Kmt2atm1.2Erns
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aqp2tm1Bxy/Aqp2tm1Bxy,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0006424 absent testis cords "missing the attachments derived from the primordial seminiferous cords that differentiate into seminiferous tubules in adolescence" [J:104330, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl6tm1.1Mtto/Bcl6tm1.1Mtto,Cd79atm1(cre)Reth/Cd79a+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6JJcl * DBA/2

 MP:0008049 increased memory T cell number "greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Gadd45btm1Flv/Gadd45btm1Flv,Gadd45gtm1Flv/Gadd45gtm1Flv
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

 MP:0008088 abnormal T-helper 1 cell differentiation "atypical production of or inability to produce the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kmt2atm1Sjk/Kmt2atm1.2Erns
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

Allelic Composition: Gadd45btm1Flv/Gadd45btm1Flv,Gadd45gtm1Flv/Gadd45gtm1Flv
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0008210 increased mature B cell number "greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Gadd45btm1Flv/Gadd45btm1Flv,Gadd45gtm1Flv/Gadd45gtm1Flv
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Gadd45btm1Flv/Gadd45btm1Flv,Gadd45gtm1Flv/Gadd45gtm1Flv
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Kmt2atm1Sjk/Kmt2atm1.2Erns
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0008871 abnormal ovarian follicle number "abnormal numbers of spheroid cell aggregations in the ovary" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
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Allelic Composition: Gadd45gtm1Jni/Gadd45gtm1Jni
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
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Allelic Composition: Kmt2atm1Sjk/Kmt2atm1.2Erns
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0011014 decreased core body temperature "reduced degree of heat natural to the internal center of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt2atm1Sjk/Kmt2atm1.2Erns
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Kmt2atm1Sjk/Kmt2atm1.2Erns
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0011698 abnormal brown adipose tissue physiology "any functional anomaly in the thermogenic form of adipose tissue that is composed of brown adipocytes" [MGI:smb]
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Allelic Composition: Kmt2atm1Sjk/Kmt2atm1.2Erns
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0020519 renal glomerular immunoglobulin deposits "any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926]
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Allelic Composition: Gadd45btm1Flv/Gadd45btm1Flv,Gadd45gtm1Flv/Gadd45gtm1Flv
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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