ENSMUSG00000015312


Mus musculus

Features
Gene ID: ENSMUSG00000015312
  
Biological name :Gadd45b
  
Synonyms : Gadd45b / Growth arrest and DNA damage-inducible protein GADD45 beta / P22339
  
Possible biological names infered from orthology : growth arrest and DNA damage inducible beta / O75293
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 80930073
Gene end: 80932204
  
Corresponding Affymetrix probe sets: 10364950 (MoGene1.0st)   1420197_at (Mouse Genome 430 2.0 Array)   1449773_s_at (Mouse Genome 430 2.0 Array)   1450971_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151426
Ensembl peptide - ENSMUSP00000015456
NCBI entrez gene - 17873     See in Manteia.
MGI - MGI:107776
RefSeq - NM_008655
RefSeq Peptide - NP_032681
swissprot - A0A1W2P6W4
swissprot - P22339
Ensembl - ENSMUSG00000015312
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gadd45baENSDARG00000027744Danio rerio
 gadd45bbENSDARG00000013576Danio rerio
 GADD45BENSGALG00000029968Gallus gallus
 O75293ENSG00000099860Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P48316 / Gadd45a / Growth arrest and DNA damage-inducible protein GADD45 alpha / P24522* / growth arrest and DNA damage inducible alpha*ENSMUSG0000003639056
Gadd45g / growth arrest and DNA damage inducible gamma / O95257*ENSMUSG0000002145353


Protein motifs (from Interpro)
Interpro ID Name
 IPR004038  Ribosomal protein L7Ae/L30e/S12e/Gadd45
 IPR024824  Growth arrest and DNA damage-inducible protein GADD45
 IPR029064  50S ribosomal protein L30e-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000185 activation of MAPKKK activity IEA
 biological_processGO:0000186 activation of MAPKK activity IDA
 biological_processGO:0006469 negative regulation of protein kinase activity IDA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006950 response to stress IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:1900745 positive regulation of p38MAPK cascade IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aqp2tm1Bxy/Aqp2tm1Bxy,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: En1tm1Gld/En1+,Ntn1Gt(ST629)Byg/Ntn1Gt(ST629)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

Allelic Composition: Gadd45btm1Flv/Gadd45btm1Flv,Gadd45gtm1Flv/Gadd45gtm1Flv
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: P2rx2tm1Ckn/P2rx2tm1Ckn,P2rx3tm1Ckn/P2rx3tm1Ckn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rb1tm1Dwg/Rb1tm1Dwg
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gadd45btm1Flv/Gadd45btm1Flv,Gadd45gtm1Flv/Gadd45gtm1Flv
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: En1tm1Gld/En1+,Ntn1Gt(ST629)Byg/Ntn1Gt(ST629)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

Allelic Composition: Gadd45btm1Flv/Gadd45btm1Flv,Gadd45gtm1Flv/Gadd45gtm1Flv
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gadd45btm1Flv/Gadd45btm1Flv,Gadd45gtm1Flv/Gadd45gtm1Flv
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

 MP:0004796 increased anti-histone antibody level "elevated level of antibodies to histones present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gadd45btm1Flv/Gadd45btm1Flv,Gadd45gtm1Flv/Gadd45gtm1Flv
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gadd45btm1Flv/Gadd45btm1Flv
Genetic Background: B6.129S6-Gadd45btm1Flv

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: En1tm1Gld/En1+,Ntn1Gt(ST629)Byg/Ntn1Gt(ST629)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: P2rx2tm1Ckn/P2rx2tm1Ckn,P2rx3tm1Ckn/P2rx3tm1Ckn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: P2rx2tm1Ckn/P2rx2tm1Ckn,P2rx3tm1Ckn/P2rx3tm1Ckn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gadd45btm1Flv/Gadd45btm1Flv
Genetic Background: B6.129S6-Gadd45btm1Flv

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: P2rx2tm1Ckn/P2rx2tm1Ckn,P2rx3tm1Ckn/P2rx3tm1Ckn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008049 increased memory T cell number "greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Gadd45btm1Flv/Gadd45btm1Flv,Gadd45gtm1Flv/Gadd45gtm1Flv
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

 MP:0008088 abnormal T-helper 1 cell differentiation "atypical production of or inability to produce the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: P2rx2tm1Ckn/P2rx2tm1Ckn,P2rx3tm1Ckn/P2rx3tm1Ckn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gadd45btm1Flv/Gadd45btm1Flv,Gadd45gtm1Flv/Gadd45gtm1Flv
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0008210 increased mature B cell number "greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Gadd45btm1Flv/Gadd45btm1Flv,Gadd45gtm1Flv/Gadd45gtm1Flv
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Gadd45btm1Flv/Gadd45btm1Flv,Gadd45gtm1Flv/Gadd45gtm1Flv
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Gadd45btm1Flv/Gadd45btm1Flv
Genetic Background: B6.129S6-Gadd45btm1Flv

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: P2rx2tm1Ckn/P2rx2tm1Ckn,P2rx3tm1Ckn/P2rx3tm1Ckn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008664 decreased interleukin-12 secretion "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
Show

Allelic Composition: P2rx2tm1Ckn/P2rx2tm1Ckn,P2rx3tm1Ckn/P2rx3tm1Ckn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: P2rx2tm1Ckn/P2rx2tm1Ckn,P2rx3tm1Ckn/P2rx3tm1Ckn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: P2rx2tm1Ckn/P2rx2tm1Ckn,P2rx3tm1Ckn/P2rx3tm1Ckn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: P2rx2tm1Ckn/P2rx2tm1Ckn,P2rx3tm1Ckn/P2rx3tm1Ckn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0020519 renal glomerular immunoglobulin deposits "any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926]
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Allelic Composition: Gadd45btm1Flv/Gadd45btm1Flv
Genetic Background: B6.129S6-Gadd45btm1Flv

Allelic Composition: Gadd45btm1Flv/Gadd45btm1Flv,Gadd45gtm1Flv/Gadd45gtm1Flv
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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