ENSGALG00000025977


Gallus gallus

Features
Gene ID: ENSGALG00000025977
  
Biological name :GADD45A
  
Synonyms : GADD45A / growth arrest and DNA damage inducible alpha
  
Possible biological names infered from orthology : Growth arrest and DNA damage-inducible protein GADD45 alpha / P24522 / P48316
  
Species: Gallus gallus
  
Chr. number: 8
Strand: 1
Band:
Gene start: 28789111
Gene end: 28790623
  
Corresponding Affymetrix probe sets: Gga.1927.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000041380
NCBI entrez gene - 693255     See in Manteia.
RefSeq - NM_001044678
RefSeq Peptide - NP_001038143
swissprot - Q2HZD6
Ensembl - ENSGALG00000025977
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gadd45aaENSDARG00000043581Danio rerio
 gadd45abENSDARG00000104571Danio rerio
 P24522ENSG00000116717Homo sapiens
 P48316ENSMUSG00000036390Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GADD45G / growth arrest and DNA damage inducible gamma / O95257*ENSGALG0000002800559
GADD45B / growth arrest and DNA damage inducible beta / O75293* / P22339* / Growth arrest and DNA damage-inducible protein GADD45 beta *ENSGALG0000002996844


Protein motifs (from Interpro)
Interpro ID Name
 IPR004038  Ribosomal protein L7Ae/L30e/S12e/Gadd45
 IPR024824  Growth arrest and DNA damage-inducible protein GADD45
 IPR029064  50S ribosomal protein L30e-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000185 activation of MAPKKK activity IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0006950 response to stress IEA
 biological_processGO:0007098 centrosome cycle IEA
 biological_processGO:0042770 signal transduction in response to DNA damage IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071479 cellular response to ionizing radiation IEA
 biological_processGO:0071850 mitotic cell cycle arrest IEA
 biological_processGO:1900745 positive regulation of p38MAPK cascade IEA
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA


Pathways (from Reactome)
Pathway description
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000007768 AURKA / aurora kinase A / O14965* / P97477*  / reaction / complex
 ENSGALG00000029292 PCNA / Q9DEA3 / Proliferating cell nuclear antigen / P17918* / P12004* / Pcna-ps2*  / complex / reaction






 

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