ENSGALG00000029292


Gallus gallus

Features
Gene ID: ENSGALG00000029292
  
Biological name :PCNA
  
Synonyms : PCNA / Proliferating cell nuclear antigen / Q9DEA3
  
Possible biological names infered from orthology : P12004 / P17918 / Pcna-ps2
  
Species: Gallus gallus
  
Chr. number: 22
Strand: 1
Band:
Gene start: 342048
Gene end: 345143
  
Corresponding Affymetrix probe sets: Gga.4036.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000045018
Ensembl peptide - ENSGALP00000064149
Ensembl peptide - ENSGALP00000062926
Ensembl peptide - ENSGALP00000050878
NCBI entrez gene - 373984     See in Manteia.
RefSeq - NM_204170
RefSeq Peptide - NP_989501
swissprot - A0A1L1RVR8
swissprot - A0A1D5PDN3
swissprot - A0A1D5NXC3
swissprot - Q9DEA3
Ensembl - ENSGALG00000029292
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pcnaENSDARG00000054155Danio rerio
 PCNAENSG00000132646Homo sapiens
 PcnaENSMUSG00000027342Mus musculus
 Pcna-ps2ENSMUSG00000067608Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000730  Proliferating cell nuclear antigen, PCNA
 IPR022648  Proliferating cell nuclear antigen, PCNA, N-terminal
 IPR022649  Proliferating cell nuclear antigen, PCNA, C-terminal
 IPR022659  Proliferating cell nuclear antigen, PCNA, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006259 DNA metabolic process IEA
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006272 leading strand elongation IBA
 biological_processGO:0006275 regulation of DNA replication IEA
 biological_processGO:0006281 DNA repair TAS
 biological_processGO:0006298 mismatch repair IEA
 biological_processGO:0019985 translesion synthesis IEA
 biological_processGO:0030855 epithelial cell differentiation IEA
 biological_processGO:0032077 positive regulation of deoxyribonuclease activity IEA
 biological_processGO:0034644 cellular response to UV IEA
 biological_processGO:0045739 positive regulation of DNA repair IEA
 biological_processGO:0045740 positive regulation of DNA replication IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005657 replication fork IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0043596 nuclear replication fork IEA
 cellular_componentGO:0043626 PCNA complex IEA
 cellular_componentGO:0070557 PCNA-p21 complex IEA
 molecular_functionGO:0000701 purine-specific mismatch base pair DNA N-glycosylase activity IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0030337 DNA polymerase processivity factor activity IEA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IEA
 molecular_functionGO:0032139 dinucleotide insertion or deletion binding IEA
 molecular_functionGO:0032405 MutLalpha complex binding IEA
 molecular_functionGO:0035035 histone acetyltransferase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0070182 DNA polymerase binding IEA


Pathways (from Reactome)
Pathway description
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Polymerase switching on the C-strand of the telomere
Removal of the Flap Intermediate from the C-strand
RAD18 and ubiquitinated PCNA-mediated recruitment of translesion polymerases
Nucleotide Excision Repair
SUMOylation of DNA replication proteins
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand
E3 ubiquitin ligases ubiquitinate target proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000734 RPA2 / RPA4* / Q13156* / P15927* / replication protein A2* / replication protein A4*  / reaction / complex
 ENSGALG00000003144 TRIM25 / Gallus gallus tripartite motif containing 25 (TRIM25), mRNA. / Q14258* / Q61510* / tripartite motif containing 25* / E3 ubiquitin/ISG15 ligase TRIM25 *  / complex
 ENSGALG00000004640 MAD2L2 / Q4KWZ6 / Mitotic spindle assembly checkpoint protein MAD2B / Q9D752* / Q9UI95* / mitotic arrest deficient 2 like 2*  / complex / reaction
 ENSGALG00000003072 RPA1 / Q5ZJJ2 / Replication protein A 70 kDa DNA-binding subunit / Q8VEE4* / P27694* / replication protein A1*  / complex / reaction
 ENSGALG00000004037 DNA2 / Q5ZKG3 / DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2 / P51530* / Q6ZQJ5* / DNA replication helicase...  / complex / reaction
 ENSGALG00000008559 CUL4B / cullin 4B / A2A432* / Q13620*  / complex / reaction
 ENSGALG00000008962 MSH2 / mutS homolog 2 / P43246* / P43247* / DNA mismatch repair protein Msh2 *  / complex / reaction
 ENSGALG00000014956 POLK / DNA polymerase kappa / Q9QUG2* / Q9UBT6* / polymerase (DNA directed), kappa*  / complex / reaction
 ENSGALG00000016312 POLA1 / DNA polymerase alpha 1, catalytic subunit / P09884* / P33609* / polymerase (DNA directed), alpha 1*  / complex / reaction
 ENSGALG00000011065 SPRTN / SprT-like N-terminal domain / G3X912* / Q9H040* / SprT-like domain-containing protein Spartan *  / reaction / complex
 ENSGALG00000010748 EXO1 / exonuclease 1 / Q9QZ11* / Q9UQ84*  / reaction
 ENSGALG00000010700 RPA3 / replication protein A3 / P35244* / Q9CQ71* / Replication protein A 14 kDa subunit *  / reaction / complex
 ENSGALG00000016766 REV1 / DNA repair protein REV1 / Q920Q2* / Q9UBZ9* / REV1, DNA directed polymerase*  / complex / reaction
 ENSGALG00000017307 POLD3 / Q5ZK28 / DNA polymerase delta subunit 3 / Q15054* / DNA polymerase delta 3, accessory subunit* / polymerase (DNA-directed), delta 3, accessory subunit*  / complex
 ENSGALG00000016278 PRIM2 / DNA primase subunit 2 / P33610* / P49643* / DNA primase large subunit *  / reaction / complex
 ENSGALG00000009837 DTL / Q5ZJW8 / Denticleless protein homolog / Q3TLR7* / Q9NZJ0* / denticleless E3 ubiquitin protein ligase homolog*  / reaction / complex
 ENSGALG00000015033 REV3L / REV3 like, DNA directed polymerase zeta catalytic subunit / O60673* / Q61493* / DNA polymerase zeta catalytic subunit *  / complex / reaction
 ENSGALG00000011993 RBX1 / ring-box 1 / P62877* / P62878* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / reaction / complex
 ENSGALG00000010957 USP1 / ubiquitin carboxyl-terminal hydrolase 1 / O94782* / Q8BJQ2* / ubiquitin specific peptidase 1*  / complex / reaction
 ENSGALG00000006428 UBE2I / P63283 / SUMO-conjugating enzyme UBC9 / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / complex / reaction
 ENSGALG00000010317 POLH / DNA polymerase eta / Q9JJN0* / Q9Y253*  / complex / reaction
 ENSGALG00000008957 MSH6 / mutS homolog 6 / P52701* / P54276* / DNA mismatch repair protein Msh6 *  / reaction / complex
 ENSGALG00000028133 UBE2V2 / Q5F3Z3 / Ubiquitin-conjugating enzyme E2 variant 2 / Q9D2M8* / Q15819* / ubiquitin conjugating enzyme E2 V2*  / complex / reaction
 ENSGALG00000033781 FEN1 / Q5ZLN4 / Flap endonuclease 1 / P39748* / flap structure-specific endonuclease 1*  / complex / reaction
 ENSGALG00000025977 GADD45A / growth arrest and DNA damage inducible alpha / P24522* / P48316* / Growth arrest and DNA damage-inducible protein GADD45 alpha *  / complex / reaction
 ENSGALG00000008435 SUMO1 / Q8QGH2 / Small ubiquitin-related modifier 1 / P63166* / P63165* / small ubiquitin-like modifier 1*  / reaction / complex
 ENSGALG00000032664 UBE2B / ubiquitin conjugating enzyme E2 B / P63146* / P63147*  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction / complex
 ENSGALG00000039169 MLH1 / mutL homolog 1 / P40692* / Q9JK91* / DNA mismatch repair protein Mlh1 *  / reaction / complex
 ENSGALG00000006052 WDR48 / Q5F3K4 / WD repeat-containing protein 48 / Q8TAF3* / Q8BH57* / WD repeat domain 48*  / reaction / complex
 ENSGALG00000029292 PCNA / Q9DEA3 / Proliferating cell nuclear antigen / P17918* / P12004* / Pcna-ps2*  / complex
 ENSGALG00000012289 SHPRH / SNF2 histone linker PHD RING helicase / Q149N8* / Q7TPQ3* / E3 ubiquitin-protein ligase SHPRH *  / reaction / complex
 ENSGALG00000042333 DDB1 / Q805F9 / DNA damage-binding protein 1 / Q16531* / Q3U1J4* / damage specific DNA binding protein 1*  / reaction / complex






 

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