ENSGALG00000033781


Gallus gallus

Features
Gene ID: ENSGALG00000033781
  
Biological name :FEN1
  
Synonyms : FEN1 / Flap endonuclease 1 / Q5ZLN4
  
Possible biological names infered from orthology : flap structure-specific endonuclease 1 / P39748
  
Species: Gallus gallus
  
Chr. number: 5
Strand: 1
Band:
Gene start: 225267
Gene end: 227948
  
Corresponding Affymetrix probe sets: Gga.4353.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000046636
NCBI entrez gene - 769677     See in Manteia.
RefSeq - NM_001079491
RefSeq Peptide - NP_001072959
swissprot - Q5ZLN4
Ensembl - ENSGALG00000033781
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fen1ENSDARG00000011404Danio rerio
 FEN1ENSG00000168496Homo sapiens
 Fen1ENSMUSG00000024742Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GEN1* / Q17RS7* / Q8BMI4* / Flap endonuclease GEN homolog 1 * / GEN1, Holliday junction 5 flap endonuclease*ENSGALG0000003103216
GEN1* / Q17RS7* / Q8BMI4* / Flap endonuclease GEN homolog 1 * / GEN1, Holliday junction 5 flap endonuclease*ENSGALG000000164687


Protein motifs (from Interpro)
Interpro ID Name
 IPR002421  5"-3" exonuclease, N-terminal
 IPR006084  XPG/Rad2 endonuclease
 IPR006085  XPG N-terminal
 IPR006086  XPG-I domain
 IPR008918  Helix-hairpin-helix motif, class 2
 IPR019974  XPG conserved site
 IPR020045  DNA polymerase I-like, H3TH domain
 IPR023426  Flap endonuclease 1
 IPR029060  PIN-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0043137 DNA replication, removal of RNA primer IEA
 biological_processGO:0045876 positive regulation of sister chromatid cohesion IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004523 RNA-DNA hybrid ribonuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0008409 5"-3" exonuclease activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016788 hydrolase activity, acting on ester bonds IEA
 molecular_functionGO:0017108 5"-flap endonuclease activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048256 flap endonuclease activity IEA


Pathways (from Reactome)
Pathway description
POLB-Dependent Long Patch Base Excision Repair
PCNA-Dependent Long Patch Base Excision Repair
HDR through MMEJ (alt-NHEJ)
Removal of the Flap Intermediate


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000734 RPA2 / RPA4* / Q13156* / P15927* / replication protein A2* / replication protein A4*  / complex
 ENSGALG00000003072 RPA1 / Q5ZJJ2 / Replication protein A 70 kDa DNA-binding subunit / Q8VEE4* / P27694* / replication protein A1*  / complex
 ENSGALG00000014982 RBBP8 / RB binding protein 8, endonuclease / Q80YR6* / Q99708* / retinoblastoma binding protein 8, endonuclease*  / complex / reaction
 ENSGALG00000010700 RPA3 / replication protein A3 / P35244* / Q9CQ71* / Replication protein A 14 kDa subunit *  / complex
 ENSGALG00000017211 MRE11 / double-strand break repair protein MRE11 / Mre11a* / Q61216* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSGALG00000029292 PCNA / Q9DEA3 / Proliferating cell nuclear antigen / P17918* / P12004* / Pcna-ps2*  / complex / reaction
 ENSGALG00000006794 RAD50* / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / reaction / complex
 ENSGALG00000009228 PARP1 / poly / P09874* / poly(ADP-ribose) polymerase 1* / poly (ADP-ribose) polymerase family, member 1*  / complex / reaction
 ENSGALG00000017307 POLD3 / Q5ZK28 / DNA polymerase delta subunit 3 / Q15054* / DNA polymerase delta 3, accessory subunit* / polymerase (DNA-directed), delta 3, accessory subunit*  / reaction
 ENSGALG00000016312 POLA1 / DNA polymerase alpha 1, catalytic subunit / P09884* / P33609* / polymerase (DNA directed), alpha 1*  / reaction
 ENSGALG00000016278 PRIM2 / DNA primase subunit 2 / P33610* / P49643* / DNA primase large subunit *  / reaction






 

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