ENSMUSG00000024742


Mus musculus

Features
Gene ID: ENSMUSG00000024742
  
Biological name :Fen1
  
Synonyms : Fen1 / flap structure-specific endonuclease 1
  
Possible biological names infered from orthology : P39748
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 10199132
Gene end: 10204169
  
Corresponding Affymetrix probe sets: 10465912 (MoGene1.0st)   1421731_a_at (Mouse Genome 430 2.0 Array)   1436454_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025651
Ensembl peptide - ENSMUSP00000112241
Ensembl peptide - ENSMUSP00000117246
Ensembl peptide - ENSMUSP00000119221
NCBI entrez gene - 14156     See in Manteia.
MGI - MGI:102779
RefSeq - XM_006526664
RefSeq - NM_001271614
RefSeq - NM_001271615
RefSeq - NM_007999
RefSeq - XM_006526661
RefSeq - XM_006526662
RefSeq - XM_006526663
RefSeq Peptide - NP_001258543
RefSeq Peptide - NP_001258544
RefSeq Peptide - NP_032025
swissprot - Q91Z50
Ensembl - ENSMUSG00000024742
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fen1ENSDARG00000011404Danio rerio
 FEN1ENSGALG00000033781Gallus gallus
 FEN1ENSG00000168496Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gen1 / Q8BMI4 / Flap endonuclease GEN homolog 1 / Q17RS7* / GEN1, Holliday junction 5 flap endonuclease*ENSMUSG0000005123522


Protein motifs (from Interpro)
Interpro ID Name
 IPR006084  XPG/Rad2 endonuclease
 IPR006085  XPG N-terminal
 IPR006086  XPG-I domain
 IPR008918  Helix-hairpin-helix motif, class 2
 IPR019974  XPG conserved site
 IPR023426  Flap endonuclease 1
 IPR029060  PIN-like domain superfamily
 IPR036279  5"-3" exonuclease, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006284 base-excision repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007613 memory IEA
 biological_processGO:0043137 DNA replication, removal of RNA primer IEA
 biological_processGO:0045876 positive regulation of sister chromatid cohesion IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004523 RNA-DNA hybrid ribonuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0008409 5"-3" exonuclease activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016788 hydrolase activity, acting on ester bonds IEA
 molecular_functionGO:0017108 5"-flap endonuclease activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048256 flap endonuclease activity IEA


Pathways (from Reactome)
Pathway description
POLB-Dependent Long Patch Base Excision Repair
Removal of the Flap Intermediate from the C-strand
PCNA-Dependent Long Patch Base Excision Repair
HDR through MMEJ (alt-NHEJ)
Removal of the Flap Intermediate


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Socs2tm1Wehi/Socs2+
Genetic Background: C57BL/6-Socs2tm1Wehi

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fen1tm3.1Bhsh/Fen1tm3.1Bhsh
Genetic Background: Not Specified

Allelic Composition: Fen1tm3.1Bhsh/Fen1+
Genetic Background: Not Specified

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Notch2tm1Yha/Notch2+
Genetic Background: B6.129-Notch2tm1Yha

Allelic Composition: Fen1tm2Klng/Fen1tm2Klng
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Notch2tm1Yha/Notch2+
Genetic Background: B6.129-Notch2tm1Yha

 MP:0000688 lymphoid hyperplasia "increased cell number in lymphatic tissues" [J:62478]
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Allelic Composition: Fen1tm2Klng/Fen1tm2Klng
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Fen1tm3.1Bhsh/Fen1tm3.1Bhsh
Genetic Background: Not Specified

Allelic Composition: Fen1tm3.1Bhsh/Fen1+
Genetic Background: Not Specified

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fen1tm2Klng/Fen1tm2Klng
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Fen1tm3.1Bhsh/Fen1tm3.1Bhsh
Genetic Background: Not Specified

Allelic Composition: Fen1tm3.1Bhsh/Fen1+
Genetic Background: Not Specified

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Fen1tm2Klng/Fen1tm2Klng
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Notch2tm1Yha/Notch2+
Genetic Background: B6.129-Notch2tm1Yha

 MP:0001178 pulmonary hypoplasia "reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Notch2tm1Yha/Notch2+
Genetic Background: B6.129-Notch2tm1Yha

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Fen1tm2Klng/Fen1tm2Klng
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fen1tm2Klng/Fen1tm2Klng
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Fen1tm2Klng/Fen1tm2Klng
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001713 reduced trophoblast cell number "fewer than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:23171]
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Allelic Composition: Ptstm1Ich/Ptstm1Ich
Genetic Background: B6.129X1-Ptstm1Ich

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Fen1tm3.1Bhsh/Fen1tm3.1Bhsh
Genetic Background: Not Specified

Allelic Composition: Fen1tm3.1Bhsh/Fen1+
Genetic Background: Not Specified

 MP:0001862 interstitial pneumonia "disorder of the lower respiratory tract, primarily affecting the alveolar wall, but may also involve the small airways and blood vessels of the lung parencyma; this is usually inflammatory in nature" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fen1tm3.1Bhsh/Fen1tm3.1Bhsh
Genetic Background: Not Specified

Allelic Composition: Fen1tm3.1Bhsh/Fen1+
Genetic Background: Not Specified

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
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Allelic Composition: Ptstm1Ich/Ptstm1Ich
Genetic Background: B6.129X1-Ptstm1Ich

 MP:0002018 malignant tumors "higher than normal incidence of locally invasive, destructive and metastatic tumors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:44427]
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Allelic Composition: Fen1tm1Rak/Fen1+,Apctm1Rak/Apc+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * SJL/J

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Ednratm7(Hand2)Hku/Ednra+
Genetic Background: chimera involves: 129 * C57BL/6 * ICR

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fen1tm2Klng/Fen1tm2Klng
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Fen1tm1Rak/Fen1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL/J

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Fen1tm3.1Bhsh/Fen1tm3.1Bhsh
Genetic Background: Not Specified

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Fen1tm2Klng/Fen1tm2Klng
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
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Allelic Composition: Fen1tm2Klng/Fen1tm2Klng
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Fen1tm3.1Bhsh/Fen1tm3.1Bhsh
Genetic Background: Not Specified

Allelic Composition: Fen1tm3.1Bhsh/Fen1+
Genetic Background: Not Specified

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fen1tm1Rak/Fen1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL/J

Allelic Composition: Fen1tm3.1Bhsh/Fen1tm3.1Bhsh
Genetic Background: Not Specified

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptstm1Ich/Ptstm1Ich
Genetic Background: B6.129X1-Ptstm1Ich

Allelic Composition: Fen1tm1Bhsh/Fen1+
Genetic Background: involves: 129S1/Sv

 MP:0002362 abnormal spleen marginal zone morphology "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Fen1tm2Klng/Fen1tm2Klng
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002499 chronic inflammation "persistent inflammatory response, often caused by persistent infection or during an autoimmune response" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Fen1tm3.1Bhsh/Fen1tm3.1Bhsh
Genetic Background: Not Specified

Allelic Composition: Fen1tm3.1Bhsh/Fen1+
Genetic Background: Not Specified

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Fen1tm3.1Bhsh/Fen1tm3.1Bhsh
Genetic Background: Not Specified

Allelic Composition: Fen1tm3.1Bhsh/Fen1+
Genetic Background: Not Specified

 MP:0003396 abnormal embryonic hematopoiesis "anomaly in the development of primarily large, nucleated erythroblasts as well as some megakaryocytes and primitive macrophages occuring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans " [J:94136, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Notch2tm1Yha/Notch2+
Genetic Background: B6.129-Notch2tm1Yha

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fen1tm1Rak/Fen1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL/J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Notch2tm1Yha/Notch2+
Genetic Background: B6.129-Notch2tm1Yha

Allelic Composition: Fen1tm3Klng/Fen1tm3Klng
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fen1tm2.1Bhsh/Fen1tm2.1Bhsh
Genetic Background: involves: 129S1/Sv

Allelic Composition: Fen1tm2.1Bhsh/Fen1+
Genetic Background: involves: 129S1/Sv

 MP:0004029 spontaneous chromosome breakage "chromosome breakage due to inherent instability of chromosomes" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Fen1tm2.1Bhsh/Fen1tm2.1Bhsh
Genetic Background: involves: 129S1/Sv

Allelic Composition: Fen1tm2.1Bhsh/Fen1+
Genetic Background: involves: 129S1/Sv

 MP:0004229 abnormal embryonic erythropoiesis "anomaly in the development of primarily large, nucleated erythroblasts occurring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch2tm1Yha/Notch2+
Genetic Background: B6.129-Notch2tm1Yha

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fen1tm3.1Bhsh/Fen1tm3.1Bhsh
Genetic Background: Not Specified

Allelic Composition: Fen1tm3.1Bhsh/Fen1+
Genetic Background: Not Specified

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fen1tm3.1Bhsh/Fen1tm3.1Bhsh
Genetic Background: Not Specified

Allelic Composition: Fen1tm3.1Bhsh/Fen1+
Genetic Background: Not Specified

 MP:0004843 abnormal Paneth cell morphology "any structural anomaly of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fen1tm1Rak/Fen1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL/J

 MP:0004957 abnormal blastocyst morphology "any structural anomaly of the preimplantation embryo of mammals consisting of a hollow sphere of cells with an outer cell layer (trophoblast) that forms the placenta, a fluid-filled cavity (blastocoele), and a cluster of cells on the interior (the inner cell mass) that forms the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptstm1Ich/Ptstm1Ich
Genetic Background: B6.129X1-Ptstm1Ich

 MP:0004964 absent inner cell mass "absence of the cells of the blastocyst that develop into the body of the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptstm1Ich/Ptstm1Ich
Genetic Background: B6.129X1-Ptstm1Ich

 MP:0004965 inner cell mass degeneration 
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Allelic Composition: Ptstm1Ich/Ptstm1Ich
Genetic Background: B6.129X1-Ptstm1Ich

 MP:0005350 increased susceptibility to autoimmune disorders "greater likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fen1tm3.1Bhsh/Fen1tm3.1Bhsh
Genetic Background: Not Specified

Allelic Composition: Fen1tm3.1Bhsh/Fen1+
Genetic Background: Not Specified

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Notch2tm1Yha/Notch2+
Genetic Background: B6.129-Notch2tm1Yha

Allelic Composition: Fen1tm3Klng/Fen1tm3Klng
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Fen1tm1Rak/Fen1+,Apctm1Rak/Apc+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * SJL/J

Allelic Composition: Fen1tm2.1Bhsh/Fen1tm2.1Bhsh
Genetic Background: involves: 129S1/Sv

Allelic Composition: Fen1tm3.1Bhsh/Fen1tm3.1Bhsh
Genetic Background: Not Specified

 MP:0005631 decreased lung weight "less than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
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Allelic Composition: Notch2tm1Yha/Notch2+
Genetic Background: B6.129-Notch2tm1Yha

 MP:0006094 adipocyte hypertrophy "increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802]
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Allelic Composition: Fen1tm2Klng/Fen1tm2Klng
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Fen1tm2.1Bhsh/Fen1tm2.1Bhsh
Genetic Background: involves: 129S1/Sv

 MP:0008019 liver tumor "presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Fen1tm2.1Bhsh/Fen1tm2.1Bhsh
Genetic Background: involves: 129S1/Sv

Allelic Composition: Fen1tm3.1Bhsh/Fen1tm3.1Bhsh
Genetic Background: Not Specified

 MP:0008057 abnormal DNA replication "any anomaly in the process whereby new strands of DNA are synthesized" [GO:0006260]
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Allelic Composition: Ptstm1Ich/Ptstm1Ich
Genetic Background: B6.129X1-Ptstm1Ich

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
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Allelic Composition: Ptstm1Ich/Ptstm1Ich
Genetic Background: B6.129X1-Ptstm1Ich

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fen1tm3.1Bhsh/Fen1tm3.1Bhsh
Genetic Background: Not Specified

Allelic Composition: Fen1tm3.1Bhsh/Fen1+
Genetic Background: Not Specified

 MP:0008404 increased cellular sensitivity to methylmethanesulfonate "greater incidence of cell death following exposure to methylmethanesulfonate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fen1tm3.1Bhsh/Fen1tm3.1Bhsh
Genetic Background: Not Specified

Allelic Composition: Fen1tm3.1Bhsh/Fen1+
Genetic Background: Not Specified

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: Fen1tm2Klng/Fen1tm2Klng
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
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Allelic Composition: Fen1tm2.1Bhsh/Fen1tm2.1Bhsh
Genetic Background: involves: 129S1/Sv

Allelic Composition: Fen1tm3.1Bhsh/Fen1tm3.1Bhsh
Genetic Background: Not Specified

Allelic Composition: Fen1tm3.1Bhsh/Fen1+
Genetic Background: Not Specified

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fen1tm3.1Bhsh/Fen1tm3.1Bhsh
Genetic Background: Not Specified

Allelic Composition: Fen1tm3.1Bhsh/Fen1+
Genetic Background: Not Specified

 MP:0009246 pale spleen "spleen lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch2tm1Yha/Notch2+
Genetic Background: B6.129-Notch2tm1Yha

 MP:0009590 gonad tumor "presence of abnormal rapidly proliferating cells in the testis or ovary, usually in the form of a distinct mass" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fen1tm3.1Bhsh/Fen1tm3.1Bhsh
Genetic Background: Not Specified

 MP:0010207 abnormal telomere morphology "any structural anomaly of the terminal repetitive DNA section of a chromosome which is involved in chromosomal replication and senescence, and which protects the end of the chromosome from deterioration" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fen1tm2.1Bhsh/Fen1tm2.1Bhsh
Genetic Background: involves: 129S1/Sv

 MP:0010279 increased gastrointestinal tumor incidence "greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fen1tm1Rak/Fen1+,Apctm1Rak/Apc+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * SJL/J

 MP:0010365 increased thymus tumor incidence "greater than the expected number of neoplams in the thymus occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fen1tm2.1Bhsh/Fen1tm2.1Bhsh
Genetic Background: involves: 129S1/Sv

 MP:0010948 abnormal double-strand DNA break repair "any annomaly in the process of repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix" [GO:0006302]
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Allelic Composition: Fen1tm2.1Bhsh/Fen1tm2.1Bhsh
Genetic Background: involves: 129S1/Sv

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Notch2tm1Yha/Notch2+
Genetic Background: B6.129-Notch2tm1Yha

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Gja1tm6(Gjb3)Kwi/Gja1tm6(Gjb3)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
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Allelic Composition: Ptstm1Ich/Ptstm1Ich
Genetic Background: B6.129X1-Ptstm1Ich

Allelic Composition: Fen1tm1Rak/Fen1tm1Rak
Genetic Background: involves: 129/Sv * C57BL/6 * SJL/J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Fen1tm3Klng/Fen1tm3Klng
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011143 thick lung-associated mesenchyme "increased thickness of the mesenchymal cell layer due to delay or failure of the mesenchymal compartment to thin down during the late stages of embryonic lung development" [MGI:anna]
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Allelic Composition: Notch2tm1Yha/Notch2+
Genetic Background: B6.129-Notch2tm1Yha

 MP:0011368 increased kidney apoptosis "increase in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Fen1tm3.1Bhsh/Fen1tm3.1Bhsh
Genetic Background: Not Specified

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Fen1tm2.1Bhsh/Fen1tm2.1Bhsh
Genetic Background: involves: 129S1/Sv

Allelic Composition: Fen1tm2.1Bhsh/Fen1+
Genetic Background: involves: 129S1/Sv

 MP:0020519 renal glomerular immunoglobulin deposits "any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926]
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Allelic Composition: Fen1tm3.1Bhsh/Fen1tm3.1Bhsh
Genetic Background: Not Specified

Allelic Composition: Fen1tm3.1Bhsh/Fen1+
Genetic Background: Not Specified

 MP:0030002 increased lung apoptosis "acceleration in the timing or in the number of cells of the lung undergoing programmed cell death" [ORCID:orcid.org/0000-0002-6490-7723, PMID:17589521]
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Allelic Composition: Fen1tm3.1Bhsh/Fen1tm3.1Bhsh
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020380 Rad50 / RAD50 double strand break repair protein / Q92878* / AC116366.3*  / reaction / complex
 ENSMUSG00000024854 Pold4 / Q9CWP8 / polymerase (DNA-directed), delta 4 / Q9HCU8* / AP003419.1* / DNA polymerase delta 4, accessory subunit*  / complex / reaction
 ENSMUSG00000035960 Apex1 / P28352 / DNA-(apurinic or apyrimidinic site) lyase DNA-(apurinic or apyrimidinic site) lyase, mitochondrial / P27695* / apurinic/apyrimidinic endodeoxyribonuclease 1*  / reaction / complex
 ENSMUSG00000025395 Prim1 / P20664 / DNA primase, p49 subunit / P49642* / DNA primase subunit 1*  / reaction
 ENSMUSG00000006678 Pola1 / P33609 / polymerase (DNA directed), alpha 1 / P09884* / DNA polymerase alpha 1, catalytic subunit*  / reaction
 ENSMUSG00000038644 Pold1 / P52431 / polymerase (DNA directed), delta 1, catalytic subunit / P28340* / DNA polymerase delta 1, catalytic subunit*  / reaction / complex
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / complex / reaction
 ENSMUSG00000031536 Polb / Q8K409 / polymerase (DNA directed), beta / P06746* / DNA polymerase beta*  / reaction / complex
 ENSMUSG00000031928 Mre11a / Q61216 / Double-strand break repair protein MRE11 / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSMUSG00000034206 Polq / Q8CGS6 / polymerase (DNA directed), theta / O75417* / DNA polymerase theta*  / complex / reaction
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / reaction / complex
 ENSMUSG00000020471 Pold2 / O35654 / polymerase (DNA directed), delta 2, regulatory subunit / P49005* / DNA polymerase delta 2, accessory subunit*  / reaction / complex
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / reaction / complex
 ENSMUSG00000028224 Nbn / Q9R207 / Nibrin / O60934*  / complex / reaction
 ENSMUSG00000041238 Rbbp8 / Q80YR6 / retinoblastoma binding protein 8, endonuclease / Q99708* / RB binding protein 8, endonuclease*  / complex / reaction
 ENSMUSG00000027342 Pcna / P17918 / proliferating cell nuclear antigen / P12004*  / complex / reaction
 ENSMUSG00000026134 Prim2 / P33610 / DNA primase large subunit / P49643* / DNA primase subunit 2*  / reaction
 ENSMUSG00000026496 Parp1 / poly (ADP-ribose) polymerase family, member 1 / P09874* / poly(ADP-ribose) polymerase 1*  / complex / reaction
 ENSMUSG00000024833 Pola2 / P33611 / polymerase (DNA directed), alpha 2 / Q14181* / DNA polymerase alpha 2, accessory subunit*  / reaction






 

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