ENSMUSG00000025395


Mus musculus

Features
Gene ID: ENSMUSG00000025395
  
Biological name :Prim1
  
Synonyms : DNA primase, p49 subunit / P20664 / Prim1
  
Possible biological names infered from orthology : DNA primase subunit 1 / P49642
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: D3
Gene start: 128015168
Gene end: 128030037
  
Corresponding Affymetrix probe sets: 10367076 (MoGene1.0st)   1418369_at (Mouse Genome 430 2.0 Array)   1449061_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026461
Ensembl peptide - ENSMUSP00000136556
NCBI entrez gene - 19075     See in Manteia.
MGI - MGI:97757
RefSeq - NM_008921
RefSeq Peptide - NP_032947
swissprot - J3QN19
swissprot - P20664
swissprot - Q5FW94
Ensembl - ENSMUSG00000025395
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prim1ENSDARG00000040163Danio rerio
 PRIM1ENSGALG00000041973Gallus gallus
 PRIM1ENSG00000198056Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002755  DNA primase, small subunit
 IPR014052  DNA primase, small subunit, eukaryotic/archaeal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006269 DNA replication, synthesis of RNA primer IEA
 cellular_componentGO:0005658 alpha DNA polymerase:primase complex IBA
 molecular_functionGO:0003697 single-stranded DNA binding IBA
 molecular_functionGO:0003896 DNA primase activity IEA
 molecular_functionGO:0003899 DNA-directed 5"-3" RNA polymerase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Polymerase switching on the C-strand of the telomere
Telomere C-strand synthesis initiation
DNA replication initiation
Activation of the pre-replicative complex
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006678 Pola1 / P33609 / polymerase (DNA directed), alpha 1 / P09884* / DNA polymerase alpha 1, catalytic subunit*  / reaction / complex
 ENSMUSG00000007080 Pole / Q9WVF7 / polymerase (DNA directed), epsilon / Q07864* / DNA polymerase epsilon, catalytic subunit*  / complex / reaction
 ENSMUSG00000020974 Pole2 / O54956 / polymerase (DNA directed), epsilon 2 (p59 subunit) / P56282* / DNA polymerase epsilon 2, accessory subunit*  / reaction / complex
 ENSMUSG00000026134 Prim2 / P33610 / DNA primase large subunit / P49643* / DNA primase subunit 2*  / reaction / complex
 ENSMUSG00000024742 Fen1 / flap structure-specific endonuclease 1 / P39748*  / reaction
 ENSMUSG00000024833 Pola2 / P33611 / polymerase (DNA directed), alpha 2 / Q14181* / DNA polymerase alpha 2, accessory subunit*  / complex / reaction
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / reaction / complex
 ENSMUSG00000025395 Prim1 / P20664 / DNA primase, p49 subunit / P49642* / DNA primase subunit 1*  / reaction
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / complex / reaction
 ENSMUSG00000036875 Dna2 / Q6ZQJ5 / DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2 / P51530* / DNA replication helicase/nuclease 2*  / reaction / complex
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / reaction / complex
 ENSMUSG00000024854 Pold4 / Q9CWP8 / polymerase (DNA-directed), delta 4 / Q9HCU8* / AP003419.1* / DNA polymerase delta 4, accessory subunit*  / reaction / complex
 ENSMUSG00000028394 Pole3 / polymerase (DNA directed), epsilon 3 (p17 subunit) / Q9NRF9* / DNA polymerase epsilon 3, accessory subunit*  / complex / reaction
 ENSMUSG00000027342 Pcna / P17918 / proliferating cell nuclear antigen / P12004*  / complex / reaction
 ENSMUSG00000038644 Pold1 / P52431 / polymerase (DNA directed), delta 1, catalytic subunit / P28340* / DNA polymerase delta 1, catalytic subunit*  / reaction / complex
 ENSMUSG00000030042 Pole4 / Q9CQ36 / polymerase (DNA-directed), epsilon 4 (p12 subunit) / Q9NR33* / DNA polymerase epsilon 4, accessory subunit*  / complex / reaction
 ENSMUSG00000020471 Pold2 / O35654 / polymerase (DNA directed), delta 2, regulatory subunit / P49005* / DNA polymerase delta 2, accessory subunit*  / complex / reaction






 

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