ENSMUSG00000026134


Mus musculus

Features
Gene ID: ENSMUSG00000026134
  
Biological name :Prim2
  
Synonyms : DNA primase large subunit / P33610 / Prim2
  
Possible biological names infered from orthology : DNA primase subunit 2 / P49643
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: B
Gene start: 33453810
Gene end: 33669795
  
Corresponding Affymetrix probe sets: 10353733 (MoGene1.0st)   1418035_a_at (Mouse Genome 430 2.0 Array)   1418036_at (Mouse Genome 430 2.0 Array)   1445474_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027312
NCBI entrez gene - 19076     See in Manteia.
MGI - MGI:97758
RefSeq - NM_008922
RefSeq Peptide - NP_032948
swissprot - P33610
Ensembl - ENSMUSG00000026134
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prim2ENSDARG00000052721Danio rerio
 PRIM2ENSGALG00000016278Gallus gallus
 PRIM2ENSG00000146143Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007238  DNA primase large subunit, eukaryotic/archaeal
 IPR016558  DNA primase, large subunit, eukaryotic


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006269 DNA replication, synthesis of RNA primer IEA
 biological_processGO:0071897 DNA biosynthetic process IEA
 cellular_componentGO:0005658 alpha DNA polymerase:primase complex IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IBA
 molecular_functionGO:0003887 DNA-directed DNA polymerase activity IBA
 molecular_functionGO:0003896 DNA primase activity IBA
 molecular_functionGO:0003899 DNA-directed 5"-3" RNA polymerase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051539 4 iron, 4 sulfur cluster binding IEA


Pathways (from Reactome)
Pathway description
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Polymerase switching on the C-strand of the telomere
Telomere C-strand synthesis initiation
DNA replication initiation
Activation of the pre-replicative complex
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006678 Pola1 / P33609 / polymerase (DNA directed), alpha 1 / P09884* / DNA polymerase alpha 1, catalytic subunit*  / reaction / complex
 ENSMUSG00000007080 Pole / Q9WVF7 / polymerase (DNA directed), epsilon / Q07864* / DNA polymerase epsilon, catalytic subunit*  / reaction / complex
 ENSMUSG00000020974 Pole2 / O54956 / polymerase (DNA directed), epsilon 2 (p59 subunit) / P56282* / DNA polymerase epsilon 2, accessory subunit*  / complex / reaction
 ENSMUSG00000036875 Dna2 / Q6ZQJ5 / DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2 / P51530* / DNA replication helicase/nuclease 2*  / reaction / complex
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / reaction / complex
 ENSMUSG00000025395 Prim1 / P20664 / DNA primase, p49 subunit / P49642* / DNA primase subunit 1*  / complex / reaction
 ENSMUSG00000026134 Prim2 / P33610 / DNA primase large subunit / P49643* / DNA primase subunit 2*  / reaction
 ENSMUSG00000024833 Pola2 / P33611 / polymerase (DNA directed), alpha 2 / Q14181* / DNA polymerase alpha 2, accessory subunit*  / reaction / complex
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / reaction / complex
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / reaction / complex
 ENSMUSG00000024742 Fen1 / flap structure-specific endonuclease 1 / P39748*  / reaction
 ENSMUSG00000024854 Pold4 / Q9CWP8 / polymerase (DNA-directed), delta 4 / Q9HCU8* / AP003419.1* / DNA polymerase delta 4, accessory subunit*  / complex / reaction
 ENSMUSG00000028394 Pole3 / polymerase (DNA directed), epsilon 3 (p17 subunit) / Q9NRF9* / DNA polymerase epsilon 3, accessory subunit*  / reaction / complex
 ENSMUSG00000027342 Pcna / P17918 / proliferating cell nuclear antigen / P12004*  / reaction / complex
 ENSMUSG00000038644 Pold1 / P52431 / polymerase (DNA directed), delta 1, catalytic subunit / P28340* / DNA polymerase delta 1, catalytic subunit*  / reaction / complex
 ENSMUSG00000030042 Pole4 / Q9CQ36 / polymerase (DNA-directed), epsilon 4 (p12 subunit) / Q9NR33* / DNA polymerase epsilon 4, accessory subunit*  / reaction / complex
 ENSMUSG00000020471 Pold2 / O35654 / polymerase (DNA directed), delta 2, regulatory subunit / P49005* / DNA polymerase delta 2, accessory subunit*  / complex / reaction






 

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