ENSMUSG00000007080


Mus musculus

Features
Gene ID: ENSMUSG00000007080
  
Biological name :Pole
  
Synonyms : Pole / polymerase (DNA directed), epsilon / Q9WVF7
  
Possible biological names infered from orthology : DNA polymerase epsilon, catalytic subunit / Q07864
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: F
Gene start: 110286306
Gene end: 110337474
  
Corresponding Affymetrix probe sets: 10524169 (MoGene1.0st)   1448650_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000007296
Ensembl peptide - ENSMUSP00000108101
Ensembl peptide - ENSMUSP00000108100
NCBI entrez gene - 18973     See in Manteia.
MGI - MGI:1196391
RefSeq - NM_011132
RefSeq - XM_017320715
RefSeq Peptide - NP_035262
swissprot - E9QAP6
swissprot - Q9WVF7
swissprot - E9QAP5
Ensembl - ENSMUSG00000007080
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 poleENSDARG00000058533Danio rerio
 ENSGALG00000039384Gallus gallus
 ENSGALG00000007665Gallus gallus
 POLEENSG00000177084Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006133  DNA-directed DNA polymerase, family B, exonuclease domain
 IPR006134  DNA-directed DNA polymerase, family B, multifunctional domain
 IPR006172  DNA-directed DNA polymerase, family B
 IPR012337  Ribonuclease H-like superfamily
 IPR013697  DNA polymerase epsilon, catalytic subunit A, C-terminal
 IPR023211  DNA polymerase, palm domain superfamily
 IPR029703  DNA polymerase epsilon catalytic subunit
 IPR036397  Ribonuclease H superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IEA
 biological_processGO:0000278 mitotic cell cycle IBA
 biological_processGO:0000731 DNA synthesis involved in DNA repair IEA
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006272 leading strand elongation IBA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006287 base-excision repair, gap-filling IEA
 biological_processGO:0006297 nucleotide-excision repair, DNA gap filling IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0045004 DNA replication proofreading IBA
 biological_processGO:0048568 embryonic organ development IEA
 biological_processGO:0071897 DNA biosynthetic process IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008622 epsilon DNA polymerase complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003887 DNA-directed DNA polymerase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0008310 single-stranded DNA 3"-5" exodeoxyribonuclease activity IBA
 molecular_functionGO:0008408 3"-5" exonuclease activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051539 4 iron, 4 sulfur cluster binding IEA


Pathways (from Reactome)
Pathway description
Recognition of DNA damage by PCNA-containing replication complex
Telomere C-strand synthesis initiation
PCNA-Dependent Long Patch Base Excision Repair
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
DNA replication initiation
Activation of the pre-replicative complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prdm1tm1.1Clme/Prdm1tm2.1Liz
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Poletm1.1Bdp/Poletm1.1Bdp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pold1tm1.1Bdp/Pold1tm1.1Bdp,Poletm1.1Bdp/Poletm1.1Bdp
Genetic Background: B6.129-Poletm1.1Bdp Pold1tm1.1Bdp

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prdm1tm1.1Clme/Prdm1tm2.1Liz
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

Allelic Composition: Poletm1.1Bdp/Poletm1.1Bdp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Pold1tm1.1Bdp/Pold1tm1.1Bdp,Poletm1.1Bdp/Poletm1.1Bdp
Genetic Background: B6.129-Poletm1.1Bdp Pold1tm1.1Bdp

 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Prdm1tm1.1Clme/Prdm1tm2.1Liz
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

 MP:0002957 intestinal adenocarcinoma "malignant neoplasm of epithelial cells in the intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Prdm1tm1.1Clme/Prdm1tm2.1Liz
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Prdm1tm1.1Clme/Prdm1tm2.1Liz
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

 MP:0009309 small intestine adenocarcinoma "malignant neoplasm of epithelial cells in the small intestine" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Prdm1tm1.1Clme/Prdm1tm2.1Liz
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

 MP:0009314 colon adenocarcinoma "malignant neoplasm of epithelial cells in the colon" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Prdm1tm1.1Clme/Prdm1tm2.1Liz
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

 MP:0009321 histiocytic sarcoma 
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Allelic Composition: Prdm1tm1.1Clme/Prdm1tm2.1Liz
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

 MP:0010300 increased skin tumor incidence "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pold1tm1.1Bdp/Pold1tm1.1Bdp,Poletm1.1Bdp/Poletm1.1Bdp
Genetic Background: B6.129-Poletm1.1Bdp Pold1tm1.1Bdp

 MP:0010383 increased adenoma incidence "greater than the expected number of a benign epithelial neoplasm with a glandular organization, occurring in a specific population in a given time period; this tumor type usually does not invade or infiltrate surrounding tissue but may remain a benign tumor or progress to malignancy" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:C04.557.470.035]
Show

Allelic Composition: Prdm1tm1.1Clme/Prdm1tm2.1Liz
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Mlh1tm1Rak/Mlh1tm1Rak,Pold1tm1.1Bdp/Pold1tm1.1Bdp
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J

 MP:0011095 complete embryonic lethality between implantation and placentation "death of all organisms of a given genotype in a population between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]
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Allelic Composition: Hsp90aa1Tg(Tyr)2396BOve/Hsp90aa1Tg(Tyr)2396BOve
Genetic Background: FVB/N-Hsp90aa1Tg(Tyr)2396BOve

 MP:0011111 complete lethality during fetal growth through weaning "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and weaning age (Mus: E14 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Mlh1tm1Rak/Mlh1tm1Rak,Pold1tm1.1Bdp/Pold1tm1.1Bdp
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Prdm1tm1.1Clme/Prdm1tm2.1Liz
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025395 Prim1 / P20664 / DNA primase, p49 subunit / P49642* / DNA primase subunit 1*  / reaction / complex
 ENSMUSG00000030042 Pole4 / Q9CQ36 / polymerase (DNA-directed), epsilon 4 (p12 subunit) / Q9NR33* / DNA polymerase epsilon 4, accessory subunit*  / complex
 ENSMUSG00000026134 Prim2 / P33610 / DNA primase large subunit / P49643* / DNA primase subunit 2*  / reaction / complex
 ENSMUSG00000024833 Pola2 / P33611 / polymerase (DNA directed), alpha 2 / Q14181* / DNA polymerase alpha 2, accessory subunit*  / complex / reaction
 ENSMUSG00000006678 Pola1 / P33609 / polymerase (DNA directed), alpha 1 / P09884* / DNA polymerase alpha 1, catalytic subunit*  / reaction / complex
 ENSMUSG00000028394 Pole3 / polymerase (DNA directed), epsilon 3 (p17 subunit) / Q9NRF9* / DNA polymerase epsilon 3, accessory subunit*  / complex
 ENSMUSG00000020974 Pole2 / O54956 / polymerase (DNA directed), epsilon 2 (p59 subunit) / P56282* / DNA polymerase epsilon 2, accessory subunit*  / complex






 

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