ENSMUSG00000006678


Mus musculus

Features
Gene ID: ENSMUSG00000006678
  
Biological name :Pola1
  
Synonyms : P33609 / Pola1 / polymerase (DNA directed), alpha 1
  
Possible biological names infered from orthology : DNA polymerase alpha 1, catalytic subunit / P09884
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: C3
Gene start: 93304767
Gene end: 93632155
  
Corresponding Affymetrix probe sets: 10605674 (MoGene1.0st)   1419397_at (Mouse Genome 430 2.0 Array)   1459319_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006856
NCBI entrez gene - 18968     See in Manteia.
MGI - MGI:99660
RefSeq - NM_008892
RefSeq - XM_006527905
RefSeq Peptide - NP_032918
swissprot - P33609
Ensembl - ENSMUSG00000006678
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pola1ENSDARG00000045308Danio rerio
 POLA1ENSGALG00000016312Gallus gallus
 POLA1ENSG00000101868Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006133  DNA-directed DNA polymerase, family B, exonuclease domain
 IPR006134  DNA-directed DNA polymerase, family B, multifunctional domain
 IPR006172  DNA-directed DNA polymerase, family B
 IPR012337  Ribonuclease H-like superfamily
 IPR015088  Zinc finger, DNA-directed DNA polymerase, family B, alpha
 IPR017964  DNA-directed DNA polymerase, family B, conserved site
 IPR023211  DNA polymerase, palm domain superfamily
 IPR024647  DNA polymerase alpha catalytic subunit, N-terminal domain
 IPR036397  Ribonuclease H superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication ISO
 biological_processGO:0006269 DNA replication, synthesis of RNA primer ISO
 biological_processGO:0006270 DNA replication initiation ISO
 biological_processGO:0006271 DNA strand elongation involved in DNA replication ISO
 biological_processGO:0006272 leading strand elongation ISO
 biological_processGO:0006273 lagging strand elongation ISO
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining IBA
 biological_processGO:0008283 cell proliferation ISS
 biological_processGO:0071897 DNA biosynthetic process IEA
 cellular_componentGO:0000785 chromatin ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005635 nuclear envelope ISS
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005658 alpha DNA polymerase:primase complex ISO
 cellular_componentGO:0005730 nucleolus ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016363 nuclear matrix ISO
 molecular_functionGO:0000166 nucleotide binding ISO
 molecular_functionGO:0001882 nucleoside binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003682 chromatin binding ISS
 molecular_functionGO:0003887 DNA-directed DNA polymerase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008408 3"-5" exonuclease activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051539 4 iron, 4 sulfur cluster binding IEA


Pathways (from Reactome)
Pathway description
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Polymerase switching on the C-strand of the telomere
Telomere C-strand synthesis initiation
DNA replication initiation
Activation of the pre-replicative complex
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Relbtm1Brv/Relbtm1Brv
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000036875 Dna2 / Q6ZQJ5 / DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2 / P51530* / DNA replication helicase/nuclease 2*  / reaction / complex
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / reaction / complex
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / reaction / complex
 ENSMUSG00000024833 Pola2 / P33611 / polymerase (DNA directed), alpha 2 / Q14181* / DNA polymerase alpha 2, accessory subunit*  / complex / reaction
 ENSMUSG00000025395 Prim1 / P20664 / DNA primase, p49 subunit / P49642* / DNA primase subunit 1*  / complex / reaction
 ENSMUSG00000026134 Prim2 / P33610 / DNA primase large subunit / P49643* / DNA primase subunit 2*  / reaction / complex
 ENSMUSG00000006678 Pola1 / P33609 / polymerase (DNA directed), alpha 1 / P09884* / DNA polymerase alpha 1, catalytic subunit*  / reaction
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / complex / reaction
 ENSMUSG00000007080 Pole / Q9WVF7 / polymerase (DNA directed), epsilon / Q07864* / DNA polymerase epsilon, catalytic subunit*  / complex / reaction
 ENSMUSG00000020974 Pole2 / O54956 / polymerase (DNA directed), epsilon 2 (p59 subunit) / P56282* / DNA polymerase epsilon 2, accessory subunit*  / complex / reaction
 ENSMUSG00000024742 Fen1 / flap structure-specific endonuclease 1 / P39748*  / reaction
 ENSMUSG00000024854 Pold4 / Q9CWP8 / polymerase (DNA-directed), delta 4 / Q9HCU8* / AP003419.1* / DNA polymerase delta 4, accessory subunit*  / complex / reaction
 ENSMUSG00000028394 Pole3 / polymerase (DNA directed), epsilon 3 (p17 subunit) / Q9NRF9* / DNA polymerase epsilon 3, accessory subunit*  / complex / reaction
 ENSMUSG00000027342 Pcna / P17918 / proliferating cell nuclear antigen / P12004*  / complex / reaction
 ENSMUSG00000038644 Pold1 / P52431 / polymerase (DNA directed), delta 1, catalytic subunit / P28340* / DNA polymerase delta 1, catalytic subunit*  / reaction / complex
 ENSMUSG00000030042 Pole4 / Q9CQ36 / polymerase (DNA-directed), epsilon 4 (p12 subunit) / Q9NR33* / DNA polymerase epsilon 4, accessory subunit*  / reaction / complex
 ENSMUSG00000020471 Pold2 / O35654 / polymerase (DNA directed), delta 2, regulatory subunit / P49005* / DNA polymerase delta 2, accessory subunit*  / complex / reaction






 

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