ENSMUSG00000028394


Mus musculus

Features
Gene ID: ENSMUSG00000028394
  
Biological name :Pole3
  
Synonyms : Pole3 / polymerase (DNA directed), epsilon 3 (p17 subunit)
  
Possible biological names infered from orthology : DNA polymerase epsilon 3, accessory subunit / Q9NRF9
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: B3
Gene start: 62522649
Gene end: 62525068
  
Corresponding Affymetrix probe sets: 10513622 (MoGene1.0st)   1421015_s_at (Mouse Genome 430 2.0 Array)   1452743_at (Mouse Genome 430 2.0 Array)   1459816_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030091
Ensembl peptide - ENSMUSP00000114486
NCBI entrez gene - 59001     See in Manteia.
MGI - MGI:1933378
RefSeq - NM_021498
RefSeq Peptide - NP_067473
swissprot - D6RDT4
swissprot - A0A0R4J091
Ensembl - ENSMUSG00000028394
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pole3ENSDARG00000008551Danio rerio
 POLE3ENSGALG00000008873Gallus gallus
 POLE3ENSG00000148229Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nfyb / P63139 / Nuclear transcription factor Y subunit beta / P25208*ENSMUSG0000002024828


Protein motifs (from Interpro)
Interpro ID Name
 IPR003958  Transcription factor CBF/NF-Y/archaeal histone domain
 IPR009072  Histone-fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0043966 histone H3 acetylation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IEA
 cellular_componentGO:0008622 epsilon DNA polymerase complex IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Recognition of DNA damage by PCNA-containing replication complex
Telomere C-strand synthesis initiation
PCNA-Dependent Long Patch Base Excision Repair
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
DNA replication initiation
Activation of the pre-replicative complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000007080 Pole / Q9WVF7 / polymerase (DNA directed), epsilon / Q07864* / DNA polymerase epsilon, catalytic subunit*  / complex
 ENSMUSG00000020974 Pole2 / O54956 / polymerase (DNA directed), epsilon 2 (p59 subunit) / P56282* / DNA polymerase epsilon 2, accessory subunit*  / complex
 ENSMUSG00000024833 Pola2 / P33611 / polymerase (DNA directed), alpha 2 / Q14181* / DNA polymerase alpha 2, accessory subunit*  / reaction / complex
 ENSMUSG00000026134 Prim2 / P33610 / DNA primase large subunit / P49643* / DNA primase subunit 2*  / complex / reaction
 ENSMUSG00000025395 Prim1 / P20664 / DNA primase, p49 subunit / P49642* / DNA primase subunit 1*  / reaction / complex
 ENSMUSG00000006678 Pola1 / P33609 / polymerase (DNA directed), alpha 1 / P09884* / DNA polymerase alpha 1, catalytic subunit*  / complex / reaction
 ENSMUSG00000030042 Pole4 / Q9CQ36 / polymerase (DNA-directed), epsilon 4 (p12 subunit) / Q9NR33* / DNA polymerase epsilon 4, accessory subunit*  / complex






 

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