ENSG00000148229


Homo sapiens

Features
Gene ID: ENSG00000148229
  
Biological name :POLE3
  
Synonyms : DNA polymerase epsilon 3, accessory subunit / POLE3 / Q9NRF9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: q32
Gene start: 113407235
Gene end: 113410672
  
Corresponding Affymetrix probe sets: 208828_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000363286
Ensembl peptide - ENSP00000363284
NCBI entrez gene - 54107     See in Manteia.
OMIM - 607267
RefSeq - NM_001278255
RefSeq - NM_017443
RefSeq Peptide - NP_001265184
RefSeq Peptide - NP_059139
swissprot - Q9NRF9
swissprot - A0A024R829
Ensembl - ENSG00000148229
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pole3ENSDARG00000008551Danio rerio
 POLE3ENSGALG00000008873Gallus gallus
 Pole3ENSMUSG00000028394Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NFYB / P25208 / nuclear transcription factor Y subunit betaENSG0000012083729


Protein motifs (from Interpro)
Interpro ID Name
 IPR003958  Transcription factor CBF/NF-Y/archaeal histone domain
 IPR009072  Histone-fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle TAS
 biological_processGO:0006260 DNA replication TAS
 biological_processGO:0006270 DNA replication initiation TAS
 biological_processGO:0032201 telomere maintenance via semi-conservative replication TAS
 biological_processGO:0043966 histone H3 acetylation IDA
 biological_processGO:0071897 DNA biosynthetic process IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IDA
 cellular_componentGO:0008622 epsilon DNA polymerase complex IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003887 DNA-directed DNA polymerase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Recognition of DNA damage by PCNA-containing replication complex
Telomere C-strand synthesis initiation
PCNA-Dependent Long Patch Base Excision Repair
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
DNA replication initiation
Activation of the pre-replicative complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000115350 POLE4 / Q9NR33 / DNA polymerase epsilon 4, accessory subunit  / complex
 ENSG00000177084 POLE / Q07864 / DNA polymerase epsilon, catalytic subunit  / complex
 ENSG00000014138 POLA2 / Q14181 / DNA polymerase alpha 2, accessory subunit  / complex / reaction
 ENSG00000101868 POLA1 / P09884 / DNA polymerase alpha 1, catalytic subunit  / complex / reaction
 ENSG00000146143 PRIM2 / P49643 / DNA primase subunit 2  / reaction / complex
 ENSG00000198056 PRIM1 / P49642 / DNA primase subunit 1  / reaction / complex
 ENSG00000100479 POLE2 / P56282 / DNA polymerase epsilon 2, accessory subunit  / complex






 

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