ENSG00000100479


Homo sapiens

Features
Gene ID: ENSG00000100479
  
Biological name :POLE2
  
Synonyms : DNA polymerase epsilon 2, accessory subunit / P56282 / POLE2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q21.3
Gene start: 49643555
Gene end: 49688422
  
Corresponding Affymetrix probe sets: 205909_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000216367
Ensembl peptide - ENSP00000446313
Ensembl peptide - ENSP00000451621
Ensembl peptide - ENSP00000475468
NCBI entrez gene - 5427     See in Manteia.
OMIM - 602670
RefSeq - XM_017021375
RefSeq - NM_001197330
RefSeq - NM_001197331
RefSeq - NM_001348384
RefSeq - NM_001348385
RefSeq - NM_002692
RefSeq - XM_011536842
RefSeq - XM_011536843
RefSeq - XM_011536844
RefSeq - XM_017021374
RefSeq Peptide - NP_001184260
RefSeq Peptide - NP_001335314
RefSeq Peptide - NP_002683
RefSeq Peptide - NP_001184259
RefSeq Peptide - NP_001335313
swissprot - U3KQ22
swissprot - P56282
Ensembl - ENSG00000100479
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pole2ENSDARG00000100028Danio rerio
 POLE2ENSGALG00000012237Gallus gallus
 AC099934.2ENSMUSG00000113786Mus musculus
 Pole2ENSMUSG00000020974Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007185  DNA polymerase alpha/epsilon, subunit B
 IPR016266  DNA polymerase epsilon, subunit B
 IPR024639  DNA polymerase epsilon subunit B, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle TAS
 biological_processGO:0006260 DNA replication TAS
 biological_processGO:0006261 DNA-dependent DNA replication IBA
 biological_processGO:0006270 DNA replication initiation TAS
 biological_processGO:0006281 DNA repair TAS
 biological_processGO:0032201 telomere maintenance via semi-conservative replication TAS
 biological_processGO:0042276 error-prone translesion synthesis IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0008622 epsilon DNA polymerase complex IDA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003887 DNA-directed DNA polymerase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA


Pathways (from Reactome)
Pathway description
Recognition of DNA damage by PCNA-containing replication complex
Telomere C-strand synthesis initiation
PCNA-Dependent Long Patch Base Excision Repair
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
DNA replication initiation
Activation of the pre-replicative complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000146143 PRIM2 / P49643 / DNA primase subunit 2  / reaction / complex
 ENSG00000014138 POLA2 / Q14181 / DNA polymerase alpha 2, accessory subunit  / reaction / complex
 ENSG00000101868 POLA1 / P09884 / DNA polymerase alpha 1, catalytic subunit  / reaction / complex
 ENSG00000198056 PRIM1 / P49642 / DNA primase subunit 1  / complex / reaction
 ENSG00000115350 POLE4 / Q9NR33 / DNA polymerase epsilon 4, accessory subunit  / complex
 ENSG00000177084 POLE / Q07864 / DNA polymerase epsilon, catalytic subunit  / complex
 ENSG00000148229 POLE3 / Q9NRF9 / DNA polymerase epsilon 3, accessory subunit  / complex






 

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