ENSGALG00000012237


Gallus gallus

Features
Gene ID: ENSGALG00000012237
  
Biological name :POLE2
  
Synonyms : DNA polymerase epsilon subunit 2 / POLE2 / Q5ZKQ6
  
Possible biological names infered from orthology : AC099934.2 / DNA polymerase epsilon 2, accessory subunit / O54956 / P56282 / polymerase (DNA directed), epsilon 2 (p59 subunit)
  
Species: Gallus gallus
  
Chr. number: 5
Strand: -1
Band:
Gene start: 57744141
Gene end: 57763640
  
Corresponding Affymetrix probe sets: GgaAffx.12131.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000050255
Ensembl peptide - ENSGALP00000061368
Ensembl peptide - ENSGALP00000052295
Ensembl peptide - ENSGALP00000019955
NCBI entrez gene - 423567     See in Manteia.
RefSeq - XM_015276729
RefSeq - NM_001006493
RefSeq - XM_015276725
RefSeq - XM_015276726
RefSeq - XM_015276727
RefSeq - XM_015276728
RefSeq Peptide - NP_001006493
swissprot - A0A1L1RRE6
swissprot - A0A1D5PHL5
swissprot - A0A1D5PBX3
swissprot - Q5ZKQ6
Ensembl - ENSGALG00000012237
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pole2ENSDARG00000100028Danio rerio
 POLE2ENSG00000100479Homo sapiens
 AC099934.2ENSMUSG00000113786Mus musculus
 Pole2ENSMUSG00000020974Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007185  DNA polymerase alpha/epsilon, subunit B
 IPR016266  DNA polymerase epsilon, subunit B
 IPR024639  DNA polymerase epsilon subunit B, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006261 DNA-dependent DNA replication IBA
 biological_processGO:0042276 error-prone translesion synthesis IBA
 biological_processGO:0071897 DNA biosynthetic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0008622 epsilon DNA polymerase complex IBA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003887 DNA-directed DNA polymerase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA


Pathways (from Reactome)
Pathway description
Recognition of DNA damage by PCNA-containing replication complex
Telomere C-strand synthesis initiation
Nucleotide Excision Repair
PCNA-Dependent Long Patch Base Excision Repair
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Dual Incision in GG-NER
Dual incision in TC-NER
DNA replication initiation
Activation of the pre-replicative complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000016312 POLA1 / DNA polymerase alpha 1, catalytic subunit / P09884* / P33609* / polymerase (DNA directed), alpha 1*  / complex / reaction
 ENSGALG00000016278 PRIM2 / DNA primase subunit 2 / P33610* / P49643* / DNA primase large subunit *  / reaction / complex
 ENSGALG00000008873 POLE3 / DNA polymerase epsilon 3, accessory subunit / Q9NRF9* / polymerase (DNA directed), epsilon 3 (p17 subunit)*  / complex






 

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