ENSGALG00000016278


Gallus gallus

Features
Gene ID: ENSGALG00000016278
  
Biological name :PRIM2
  
Synonyms : DNA primase subunit 2 / PRIM2
  
Possible biological names infered from orthology : DNA primase large subunit / P33610 / P49643
  
Species: Gallus gallus
  
Chr. number: 3
Strand: -1
Band:
Gene start: 86965136
Gene end: 87048983
  
Corresponding Affymetrix probe sets: Gga.2485.1.S1_s_at (Chicken Array)   GgaAffx.11681.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000053379
Ensembl peptide - ENSGALP00000058686
Ensembl peptide - ENSGALP00000026194
NCBI entrez gene - 421878     See in Manteia.
RefSeq - NM_001012880
RefSeq - XM_015284827
RefSeq Peptide - NP_001012898
swissprot - A0A1D5PKL8
swissprot - Q5ZM06
Ensembl - ENSGALG00000016278
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prim2ENSDARG00000052721Danio rerio
 PRIM2ENSG00000146143Homo sapiens
 Prim2ENSMUSG00000026134Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007238  DNA primase large subunit, eukaryotic/archaeal
 IPR016558  DNA primase, large subunit, eukaryotic


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006269 DNA replication, synthesis of RNA primer IEA
 biological_processGO:0071897 DNA biosynthetic process IEA
 cellular_componentGO:0005658 alpha DNA polymerase:primase complex IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IBA
 molecular_functionGO:0003887 DNA-directed DNA polymerase activity IBA
 molecular_functionGO:0003896 DNA primase activity IEA
 molecular_functionGO:0003899 DNA-directed 5"-3" RNA polymerase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0019899 enzyme binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051539 4 iron, 4 sulfur cluster binding IEA


Pathways (from Reactome)
Pathway description
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Polymerase switching on the C-strand of the telomere
Telomere C-strand synthesis initiation
DNA replication initiation
Activation of the pre-replicative complex
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000734 RPA2 / RPA4* / Q13156* / P15927* / replication protein A2* / replication protein A4*  / complex / reaction
 ENSGALG00000003072 RPA1 / Q5ZJJ2 / Replication protein A 70 kDa DNA-binding subunit / Q8VEE4* / P27694* / replication protein A1*  / complex / reaction
 ENSGALG00000004037 DNA2 / Q5ZKG3 / DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2 / P51530* / Q6ZQJ5* / DNA replication helicase...  / reaction / complex
 ENSGALG00000016312 POLA1 / DNA polymerase alpha 1, catalytic subunit / P09884* / P33609* / polymerase (DNA directed), alpha 1*  / reaction / complex
 ENSGALG00000010700 RPA3 / replication protein A3 / P35244* / Q9CQ71* / Replication protein A 14 kDa subunit *  / complex / reaction
 ENSGALG00000017307 POLD3 / Q5ZK28 / DNA polymerase delta subunit 3 / Q15054* / DNA polymerase delta 3, accessory subunit* / polymerase (DNA-directed), delta 3, accessory subunit*  / complex
 ENSGALG00000029292 PCNA / Q9DEA3 / Proliferating cell nuclear antigen / P17918* / P12004* / Pcna-ps2*  / reaction / complex
 ENSGALG00000008873 POLE3 / DNA polymerase epsilon 3, accessory subunit / Q9NRF9* / polymerase (DNA directed), epsilon 3 (p17 subunit)*  / reaction / complex
 ENSGALG00000016278 PRIM2 / DNA primase subunit 2 / P33610* / P49643* / DNA primase large subunit *  / reaction
 ENSGALG00000012237 POLE2 / Q5ZKQ6 / DNA polymerase epsilon subunit 2 / O54956* / P56282* / AC099934.2* / DNA polymerase epsilon 2, accessory subunit* / polymerase (DNA directed), epsilon 2 (p59 subunit)*  / complex / reaction
 ENSGALG00000033781 FEN1 / Q5ZLN4 / Flap endonuclease 1 / P39748* / flap structure-specific endonuclease 1*  / reaction






 

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