ENSGALG00000004037


Gallus gallus

Features
Gene ID: ENSGALG00000004037
  
Biological name :DNA2
  
Synonyms : DNA2 / DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2 / Q5ZKG3
  
Possible biological names infered from orthology : DNA replication helicase/nuclease 2 / P51530 / Q6ZQJ5
  
Species: Gallus gallus
  
Chr. number: 6
Strand: -1
Band:
Gene start: 10593818
Gene end: 10608366
  
Corresponding Affymetrix probe sets: Gga.2100.1.S1_s_at (Chicken Array)   GgaAffx.12224.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000006419
NCBI entrez gene - 423688     See in Manteia.
RefSeq - NM_001006497
RefSeq - XM_015278684
RefSeq Peptide - NP_001006497
swissprot - Q5ZKG3
swissprot - F1NWZ8
Ensembl - ENSGALG00000004037
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dna2ENSDARG00000078759Danio rerio
 DNA2ENSG00000138346Homo sapiens
 Dna2ENSMUSG00000036875Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR014808  DNA replication factor Dna2, N-terminal
 IPR026851  Dna2
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000076 DNA replication checkpoint ISS
 biological_processGO:0000723 telomere maintenance IEA
 biological_processGO:0000729 DNA double-strand break processing ISS
 biological_processGO:0006260 DNA replication ISS
 biological_processGO:0006264 mitochondrial DNA replication ISS
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006284 base-excision repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:0033567 DNA replication, Okazaki fragment processing ISS
 biological_processGO:0043137 DNA replication, removal of RNA primer ISS
 biological_processGO:0043504 mitochondrial DNA repair IEA
 biological_processGO:0045740 positive regulation of DNA replication ISS
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:1902990 mitotic telomere maintenance via semi-conservative replication IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005760 gamma DNA polymerase complex ISS
 cellular_componentGO:0042645 mitochondrial nucleoid IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding ISS
 molecular_functionGO:0003678 DNA helicase activity IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0004518 nuclease activity ISS
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016890 site-specific endodeoxyribonuclease activity, specific for altered base ISS
 molecular_functionGO:0017108 5"-flap endonuclease activity ISS
 molecular_functionGO:0043139 5"-3" DNA helicase activity ISS
 molecular_functionGO:0043142 single-stranded DNA-dependent ATPase activity ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051539 4 iron, 4 sulfur cluster binding IEA


Pathways (from Reactome)
Pathway description
Removal of the Flap Intermediate from the C-strand
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Removal of the Flap Intermediate


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000734 RPA2 / RPA4* / Q13156* / P15927* / replication protein A2* / replication protein A4*  / reaction / complex
 ENSGALG00000002663 ATR / ATR serine/threonine kinase / Q13535*  / reaction / complex
 ENSGALG00000003072 RPA1 / Q5ZJJ2 / Replication protein A 70 kDa DNA-binding subunit / Q8VEE4* / P27694* / replication protein A1*  / complex / reaction
 ENSGALG00000017159 ATM / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / complex / reaction
 ENSGALG00000016312 POLA1 / DNA polymerase alpha 1, catalytic subunit / P09884* / P33609* / polymerase (DNA directed), alpha 1*  / reaction / complex
 ENSGALG00000017307 POLD3 / Q5ZK28 / DNA polymerase delta subunit 3 / Q15054* / DNA polymerase delta 3, accessory subunit* / polymerase (DNA-directed), delta 3, accessory subunit*  / complex / reaction
 ENSGALG00000029292 PCNA / Q9DEA3 / Proliferating cell nuclear antigen / P17918* / P12004* / Pcna-ps2*  / reaction / complex
 ENSGALG00000005028 TOP3A / DNA topoisomerase 3-alpha isoform 1 / O70157* / Q13472* / DNA topoisomerase III alpha* / topoisomerase (DNA) III alpha*  / complex
 ENSGALG00000005279 BRIP1 / Q3YK19 / Fanconi anemia group J protein homolog / Q5SXJ3* / Q9BX63* / BRCA1 interacting protein C-terminal helicase 1*  / complex / reaction
 ENSGALG00000016278 PRIM2 / DNA primase subunit 2 / P33610* / P49643* / DNA primase large subunit *  / reaction / complex
 ENSGALG00000017211 MRE11 / double-strand break repair protein MRE11 / Mre11a* / Q61216* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSGALG00000007155 RMI2 / Q5ZM20 / RecQ-mediated genome instability protein 2 / Q96E14* / Q3UPE3* / RecQ mediated genome instability 2*  / complex
 ENSGALG00000006794 RAD50* / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / complex / reaction
 ENSGALG00000010700 RPA3 / replication protein A3 / P35244* / Q9CQ71* / Replication protein A 14 kDa subunit *  / complex / reaction
 ENSGALG00000014982 RBBP8 / RB binding protein 8, endonuclease / Q80YR6* / Q99708* / retinoblastoma binding protein 8, endonuclease*  / complex / reaction
 ENSGALG00000040909 WRN / Werner syndrome RecQ like helicase / O09053* / Q14191*  / complex






 

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