ENSGALG00000003072


Gallus gallus

Features
Gene ID: ENSGALG00000003072
  
Biological name :RPA1
  
Synonyms : Q5ZJJ2 / Replication protein A 70 kDa DNA-binding subunit / RPA1
  
Possible biological names infered from orthology : P27694 / Q8VEE4 / replication protein A1
  
Species: Gallus gallus
  
Chr. number: 19
Strand: 1
Band:
Gene start: 5421017
Gene end: 5442516
  
Corresponding Affymetrix probe sets: Gga.4736.1.S1_at (Chicken Array)   GgaAffx.12545.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000004840
NCBI entrez gene - 417563     See in Manteia.
RefSeq - XM_015295750
RefSeq - NM_001006221
RefSeq - XM_015295751
RefSeq Peptide - NP_001006221
swissprot - Q5ZJJ2
Ensembl - ENSGALG00000003072
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rpa1ENSDARG00000003938Danio rerio
 RPA1ENSG00000132383Homo sapiens
 Rpa1ENSMUSG00000000751Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004365  OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
 IPR004591  Replication factor A protein 1
 IPR007199  Replication factor-A protein 1, N-terminal
 IPR012340  Nucleic acid-binding, OB-fold
 IPR013955  Replication factor A, C-terminal
 IPR031657  Replication protein A, OB domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000723 telomere maintenance IEA
 biological_processGO:0000724 double-strand break repair via homologous recombination IEA
 biological_processGO:0006260 DNA replication ISS
 biological_processGO:0006281 DNA repair TAS
 biological_processGO:0006284 base-excision repair IEA
 biological_processGO:0006289 nucleotide-excision repair IEA
 biological_processGO:0006298 mismatch repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0034502 protein localization to chromosome IEA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005662 DNA replication factor A complex IEA
 cellular_componentGO:0016605 PML body IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0098505 G-rich strand telomeric DNA binding IEA


Pathways (from Reactome)
Pathway description
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Removal of the Flap Intermediate from the C-strand
Activation of ATR in response to replication stress
SUMOylation of DNA damage response and repair proteins
Regulation of HSF1-mediated heat shock response
Homologous recombination repair of replication-dependent double-strand breaks
Processing of DNA double-strand break ends
Nucleotide Excision Repair
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Formation of Incision Complex in GG-NER
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Fanconi Anemia Pathway
Activation of the pre-replicative complex
Removal of the Flap Intermediate


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000734 RPA2 / RPA4* / Q13156* / P15927* / replication protein A2* / replication protein A4*  / complex
 ENSGALG00000002663 ATR / ATR serine/threonine kinase / Q13535*  / complex / reaction
 ENSGALG00000003365 RAD1 / RAD1 checkpoint DNA exonuclease / O60671* / Q9QWZ1* / Cell cycle checkpoint protein RAD1 *  / complex / reaction
 ENSGALG00000003144 TRIM25 / Gallus gallus tripartite motif containing 25 (TRIM25), mRNA. / Q14258* / Q61510* / tripartite motif containing 25* / E3 ubiquitin/ISG15 ligase TRIM25 *  / complex
 ENSGALG00000004640 MAD2L2 / Q4KWZ6 / Mitotic spindle assembly checkpoint protein MAD2B / Q9D752* / Q9UI95* / mitotic arrest deficient 2 like 2*  / complex / reaction
 ENSGALG00000007155 RMI2 / Q5ZM20 / RecQ-mediated genome instability protein 2 / Q96E14* / Q3UPE3* / RecQ mediated genome instability 2*  / reaction / complex
 ENSGALG00000033781 FEN1 / Q5ZLN4 / Flap endonuclease 1 / P39748* / flap structure-specific endonuclease 1*  / complex
 ENSGALG00000014956 POLK / DNA polymerase kappa / Q9QUG2* / Q9UBT6* / polymerase (DNA directed), kappa*  / complex / reaction
 ENSGALG00000040909 WRN / Werner syndrome RecQ like helicase / O09053* / Q14191*  / complex / reaction
 ENSGALG00000006794 RAD50* / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / reaction / complex
 ENSGALG00000034198 MCM10 / minichromosome maintenance 10 replication initiation factor / Q0VBD2* / Q7L590*  / reaction / complex
 ENSGALG00000006428 UBE2I / P63283 / SUMO-conjugating enzyme UBC9 / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSGALG00000004037 DNA2 / Q5ZKG3 / DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2 / P51530* / Q6ZQJ5* / DNA replication helicase...  / complex / reaction
 ENSGALG00000007971 SUMO2 / Q5ZJM9 / Small ubiquitin-related modifier 2 / SUMO4* / Q6EEV6* / P61957* / P61956* / small ubiquitin-like modifier 2* / small ubiquitin-like modifier 4*  / reaction
 ENSGALG00000010957 USP1 / ubiquitin carboxyl-terminal hydrolase 1 / O94782* / Q8BJQ2* / ubiquitin specific peptidase 1*  / reaction / complex
 ENSGALG00000016860 ERCC5 / DNA repair protein complementing XP-G cells / P28715* / ERCC excision repair 5, endonuclease*  / reaction / complex
 ENSGALG00000015033 REV3L / REV3 like, DNA directed polymerase zeta catalytic subunit / O60673* / Q61493* / DNA polymerase zeta catalytic subunit *  / complex / reaction
 ENSGALG00000016312 POLA1 / DNA polymerase alpha 1, catalytic subunit / P09884* / P33609* / polymerase (DNA directed), alpha 1*  / complex / reaction
 ENSGALG00000017159 ATM / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / reaction / complex
 ENSGALG00000005028 TOP3A / DNA topoisomerase 3-alpha isoform 1 / O70157* / Q13472* / DNA topoisomerase III alpha* / topoisomerase (DNA) III alpha*  / reaction / complex
 ENSGALG00000029292 PCNA / Q9DEA3 / Proliferating cell nuclear antigen / P17918* / P12004* / Pcna-ps2*  / reaction / complex
 ENSGALG00000006052 WDR48 / Q5F3K4 / WD repeat-containing protein 48 / Q8TAF3* / Q8BH57* / WD repeat domain 48*  / reaction / complex
 ENSGALG00000000102 UBE2T / ubiquitin conjugating enzyme E2 T / Q9CQ37* / Q9NPD8*  / reaction / complex
 ENSGALG00000017211 MRE11 / double-strand break repair protein MRE11 / Mre11a* / Q61216* / P49959* / MRE11 homolog, double strand break repair nuclease*  / reaction / complex
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction / complex
 ENSGALG00000010700 RPA3 / replication protein A3 / P35244* / Q9CQ71* / Replication protein A 14 kDa subunit *  / complex
 ENSGALG00000014982 RBBP8 / RB binding protein 8, endonuclease / Q80YR6* / Q99708* / retinoblastoma binding protein 8, endonuclease*  / complex / reaction
 ENSGALG00000010317 POLH / DNA polymerase eta / Q9JJN0* / Q9Y253*  / complex / reaction
 ENSGALG00000006051 CDC7 / cell division cycle 7 / O00311* / Q9Z0H0* / Cell division cycle 7-related protein kinase *  / complex / reaction
 ENSGALG00000010748 EXO1 / exonuclease 1 / Q9QZ11* / Q9UQ84*  / reaction / complex
 ENSGALG00000017307 POLD3 / Q5ZK28 / DNA polymerase delta subunit 3 / Q15054* / DNA polymerase delta 3, accessory subunit* / polymerase (DNA-directed), delta 3, accessory subunit*  / complex / reaction
 ENSGALG00000039589 HUS1* / HUS1B* / Q8NHY5* / O60921* / Q8K572* / Q8BQY8* / Checkpoint protein HUS1 * / Checkpoint protein HUS1B * / HUS1 checkpoint clamp component* / HUS1 checkpoint clamp component B*  / reaction / complex
 ENSGALG00000016278 PRIM2 / DNA primase subunit 2 / P33610* / P49643* / DNA primase large subunit *  / reaction / complex
 ENSGALG00000005279 BRIP1 / Q3YK19 / Fanconi anemia group J protein homolog / Q5SXJ3* / Q9BX63* / BRCA1 interacting protein C-terminal helicase 1*  / reaction / complex
 ENSGALG00000003720 FANCD2 / Fanconi anemia complementation group D2 / Q80V62* / Q9BXW9* / Fanconi anemia group D2 protein homolog *  / reaction / complex
 ENSGALG00000016766 REV1 / DNA repair protein REV1 / Q920Q2* / Q9UBZ9* / REV1, DNA directed polymerase*  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction / complex
 ENSGALG00000008559 CUL4B / cullin 4B / A2A432* / Q13620*  / complex / reaction
 ENSGALG00000011065 SPRTN / SprT-like N-terminal domain / G3X912* / Q9H040* / SprT-like domain-containing protein Spartan *  / complex / reaction
 ENSGALG00000009837 DTL / Q5ZJW8 / Denticleless protein homolog / Q3TLR7* / Q9NZJ0* / denticleless E3 ubiquitin protein ligase homolog*  / reaction / complex
 ENSGALG00000011993 RBX1 / ring-box 1 / P62877* / P62878* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / reaction / complex
 ENSGALG00000042333 DDB1 / Q805F9 / DNA damage-binding protein 1 / Q16531* / Q3U1J4* / damage specific DNA binding protein 1*  / reaction / complex
 ENSGALG00000032664 UBE2B / ubiquitin conjugating enzyme E2 B / P63146* / P63147*  / reaction / complex






 

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