ENSGALG00000004640


Gallus gallus

Features
Gene ID: ENSGALG00000004640
  
Biological name :MAD2L2
  
Synonyms : MAD2L2 / Mitotic spindle assembly checkpoint protein MAD2B / Q4KWZ6
  
Possible biological names infered from orthology : mitotic arrest deficient 2 like 2 / Q9D752 / Q9UI95
  
Species: Gallus gallus
  
Chr. number: 21
Strand: 1
Band:
Gene start: 5657941
Gene end: 5663660
  
Corresponding Affymetrix probe sets: Gga.7853.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000060586
Ensembl peptide - ENSGALP00000063368
Ensembl peptide - ENSGALP00000007380
Ensembl peptide - ENSGALP00000044503
Ensembl peptide - ENSGALP00000059484
NCBI entrez gene - 419493     See in Manteia.
RefSeq - XM_015296918
RefSeq - XM_015296919
RefSeq - NM_001025578
RefSeq - XM_015296917
RefSeq Peptide - NP_001020749
swissprot - Q4KWZ6
swissprot - A0A1I7Q3Z1
Ensembl - ENSGALG00000004640
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MAD2L2ENSDARG00000042456Danio rerio
 MAD2L2ENSG00000116670Homo sapiens
 Mad2l2ENSMUSG00000029003Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003511  HORMA domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000724 double-strand break repair via homologous recombination IMP
 biological_processGO:0001558 regulation of cell growth IMP
 biological_processGO:0006281 DNA repair IMP
 biological_processGO:0006302 double-strand break repair IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0009411 response to UV ISS
 biological_processGO:0010719 negative regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0010944 negative regulation of transcription by competitive promoter binding IEA
 biological_processGO:0019985 translesion synthesis TAS
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation ISS
 biological_processGO:0042177 negative regulation of protein catabolic process ISS
 biological_processGO:0042276 error-prone translesion synthesis ISS
 biological_processGO:0042772 DNA damage response, signal transduction resulting in transcription ISS
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0051301 cell division IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:1904667 negative regulation of ubiquitin protein ligase activity ISS
 biological_processGO:2000048 negative regulation of cell-cell adhesion mediated by cadherin IEA
 biological_processGO:2000678 negative regulation of transcription regulatory region DNA binding IEA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005680 anaphase-promoting complex ISS
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005819 spindle ISS
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016035 zeta DNA polymerase complex ISS
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding IEA
 molecular_functionGO:0008432 JUN kinase binding IEA
 molecular_functionGO:0017125 deoxycytidyl transferase activity ISS


Pathways (from Reactome)
Pathway description
Translesion synthesis by REV1
RAD18 and ubiquitinated PCNA-mediated recruitment of translesion polymerases
Translesion synthesis by Pol zeta
Translesion synthesis by POLK
Translesion synthesis by POLI


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000734 RPA2 / RPA4* / Q13156* / P15927* / replication protein A2* / replication protein A4*  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction / complex
 ENSGALG00000029292 PCNA / Q9DEA3 / Proliferating cell nuclear antigen / P17918* / P12004* / Pcna-ps2*  / complex / reaction
 ENSGALG00000016766 REV1 / DNA repair protein REV1 / Q920Q2* / Q9UBZ9* / REV1, DNA directed polymerase*  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction / complex
 ENSGALG00000010700 RPA3 / replication protein A3 / P35244* / Q9CQ71* / Replication protein A 14 kDa subunit *  / complex / reaction
 ENSGALG00000003072 RPA1 / Q5ZJJ2 / Replication protein A 70 kDa DNA-binding subunit / Q8VEE4* / P27694* / replication protein A1*  / complex / reaction
 ENSGALG00000014956 POLK / DNA polymerase kappa / Q9QUG2* / Q9UBT6* / polymerase (DNA directed), kappa*  / complex / reaction
 ENSGALG00000015033 REV3L / REV3 like, DNA directed polymerase zeta catalytic subunit / O60673* / Q61493* / DNA polymerase zeta catalytic subunit *  / complex / reaction






 

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