MP:0000339 | decreased intestinal cell number | "fewer than expected number of terminally differentiated cells comprising the majority of the external surface of the intestinal epithelium" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gja1tm1.1Beis/Gja1tm1.1Beis Genetic Background: B6.Cg-Gja1tm1.1Beis
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MP:0000352 | decreased cell proliferation | "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gja1tm1.1Beis/Gja1tm1.1Beis Genetic Background: B6.Cg-Gja1tm1.1Beis
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MP:0000746 | weakness | "state of being infirm or less strong than littermates" [J:45400] |
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Allelic Composition: Ndst1b2b2230Clo/Ndst1b2b2230Clo Genetic Background: C57BL/6J-Ndst1b2b2230Clo
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MP:0001116 | small gonad | "reduced size of the testis or the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193] |
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Allelic Composition: Mad2l2tm1.1Mpz/Mad2l2tm1.1Mpz Genetic Background: involves: 129S2/SvPas * BALB/cJ
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MP:0001126 | abnormal ovary morphology | "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782] |
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Allelic Composition: Mad2l2tm1.1Mpz/Mad2l2tm1.1Mpz Genetic Background: involves: 129S2/SvPas * BALB/cJ
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MP:0001127 | small ovary | "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782] |
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Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp Genetic Background: involves: 129S2/SvPas * CF1
Allelic Composition: Mad2l2tm1Ymu/Mad2l2tm1Ymu Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Mad2l2repro22/Mad2l2repro22 Genetic Background: C3.B6(Cg)-Mad2l2repro22
Allelic Composition: Mad2l2tm1.1Mpz/Mad2l2tm1.1Mpz Genetic Background: involves: 129S2/SvPas * BALB/cJ
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MP:0001147 | small testis | "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959] |
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Allelic Composition: Mad2l2tm1Ymu/Mad2l2tm1Ymu Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Mad2l2repro22/Mad2l2repro22 Genetic Background: C3.B6(Cg)-Mad2l2repro22
Allelic Composition: Mad2l2tm1.1Mpz/Mad2l2tm1.1Mpz Genetic Background: involves: 129S2/SvPas * BALB/cJ
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MP:0001152 | Leydig cell hyperplasia | "increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065] |
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Allelic Composition: Mad2l2tm1.1Mpz/Mad2l2tm1.1Mpz Genetic Background: involves: 129S2/SvPas * BALB/cJ
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MP:0001154 | seminiferous tubule degeneration | "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844] |
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Allelic Composition: Mad2l2tm1Ymu/Mad2l2tm1Ymu Genetic Background: involves: 129 * C57BL/6J
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MP:0001155 | arrest of spermatogenesis | "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271] |
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Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp Genetic Background: involves: 129S2/SvPas * CF1
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MP:0001156 | abnormal spermatogenesis | "incomplete maturation or aberrant formation of the male gametes" [J:58959] |
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Allelic Composition: Ndst1b2b2230Clo/Ndst1b2b2230Clo Genetic Background: C57BL/6J-Ndst1b2b2230Clo
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MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Ndst1b2b2230Clo/Ndst1b2b2230Clo Genetic Background: C57BL/6J-Ndst1b2b2230Clo
Allelic Composition: Mad2l2tm1.1Mpz/Mad2l2tm1.1Mpz Genetic Background: involves: 129S2/SvPas * BALB/cJ
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MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Ndst1b2b2230Clo/Ndst1b2b2230Clo Genetic Background: C57BL/6J-Ndst1b2b2230Clo
Allelic Composition: Mad2l2tm1.1Mpz/Mad2l2tm1.1Mpz Genetic Background: involves: 129S2/SvPas * BALB/cJ
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MP:0001698 | reduced embryo size | "smaller proportions of embryo compared to littermates" [J:61790] |
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Allelic Composition: Mad2l2tm1Ymu/Mad2l2tm1Ymu Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Mad2l2tm1.1Mpz/Mad2l2tm1.1Mpz Genetic Background: involves: 129S2/SvPas * BALB/cJ
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MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Mad2l2tm1.1Mpz/Mad2l2tm1.1Mpz Genetic Background: involves: 129S2/SvPas * BALB/cJ
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MP:0001925 | male infertility | "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409] |
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Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp Genetic Background: involves: 129S2/SvPas * CF1
Allelic Composition: Mad2l2tm1Ymu/Mad2l2tm1Ymu Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Mad2l2repro22/Mad2l2repro22 Genetic Background: C3.B6(Cg)-Mad2l2repro22
Allelic Composition: Mad2l2tm1.1Mpz/Mad2l2tm1.1Mpz Genetic Background: involves: 129S2/SvPas * BALB/cJ
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MP:0001926 | female infertility | "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193] |
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Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp Genetic Background: involves: 129S2/SvPas * CF1
Allelic Composition: Mad2l2tm1Ymu/Mad2l2tm1Ymu Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Mad2l2repro22/Mad2l2repro22 Genetic Background: C3.B6(Cg)-Mad2l2repro22
Allelic Composition: Mad2l2tm1.1Mpz/Mad2l2tm1.1Mpz Genetic Background: involves: 129S2/SvPas * BALB/cJ
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MP:0001931 | abnormal oogenesis | "atypical formation or failure to form the female germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782] |
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Allelic Composition: Ndst1b2b2230Clo/Ndst1b2b2230Clo Genetic Background: C57BL/6J-Ndst1b2b2230Clo
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MP:0002216 | abnormal seminiferous tubule morphology | "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Mad2l2tm1.1Mpz/Mad2l2tm1.1Mpz Genetic Background: involves: 129S2/SvPas * BALB/cJ
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MP:0002777 | absent ovarian follicles | "lack of the sac-like structures in the ovaries that surround the ova" [J:42612, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp Genetic Background: involves: 129S2/SvPas * CF1
Allelic Composition: Mad2l2tm1Ymu/Mad2l2tm1Ymu Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Mad2l2repro22/Mad2l2repro22 Genetic Background: C3.B6(Cg)-Mad2l2repro22
Allelic Composition: Mad2l2tm1.1Mpz/Mad2l2tm1.1Mpz Genetic Background: involves: 129S2/SvPas * BALB/cJ
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MP:0002784 | abnormal Sertoli cell morphology | "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Mad2l2tm1.1Mpz/Mad2l2tm1.1Mpz Genetic Background: involves: 129S2/SvPas * BALB/cJ
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MP:0002982 | abnormal germ cell migration | "defects in the orderly movement of a germ cell, a cell specialized to produce haploid gametes, from one site to another during development" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator] |
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Allelic Composition: Mad2l2tm1.1Mpz/Mad2l2tm1.1Mpz Genetic Background: involves: 129S2/SvPas * BALB/cJ
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MP:0003077 | abnormal cell cycle | "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266] |
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Allelic Composition: Mad2l2tm1.1Mpz/Mad2l2tm1.1Mpz Genetic Background: involves: 129S2/SvPas * BALB/cJ
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MP:0003202 | abnormal neuron apoptosis | "change in the timing or the number of neurons undergoing programmed cell death" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Mad2l2tm1Ymu/Mad2l2tm1Ymu Genetic Background: involves: 129 * C57BL/6J
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MP:0003578 | absent ovary | "absence of the female reproductive gland containing the germ cells" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Mad2l2tm1.1Mpz/Mad2l2tm1.1Mpz Genetic Background: involves: 129S2/SvPas * BALB/cJ
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MP:0004200 | reduced fetal size | "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mad2l2tm1.1Mpz/Mad2l2tm1.1Mpz Genetic Background: involves: 129S2/SvPas * BALB/cJ
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MP:0004806 | absent germ cells | "absence of germ cells, that is, any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Mad2l2repro22/Mad2l2repro22 Genetic Background: C3.B6(Cg)-Mad2l2repro22
Allelic Composition: Mad2l2tm1.1Mpz/Mad2l2tm1.1Mpz Genetic Background: involves: 129S2/SvPas * BALB/cJ
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MP:0004833 | ovary atrophy | "wasting of the ovary due to injury or disease resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mad2l2tm1Ymu/Mad2l2tm1Ymu Genetic Background: involves: 129 * C57BL/6J
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MP:0004852 | decreased testis weight | "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp Genetic Background: involves: 129S2/SvPas * CF1
Allelic Composition: Mad2l2tm1Ymu/Mad2l2tm1Ymu Genetic Background: involves: 129 * C57BL/6J
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MP:0004901 | decreased male germ cell number | "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp Genetic Background: involves: 129S2/SvPas * CF1
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MP:0005159 | azoospermia | "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp Genetic Background: involves: 129S2/SvPas * CF1
Allelic Composition: Mad2l2tm1Ymu/Mad2l2tm1Ymu Genetic Background: involves: 129 * C57BL/6J
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MP:0005431 | oocyte depletion | "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp Genetic Background: involves: 129S2/SvPas * CF1
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MP:0006428 | ectopic Sertoli cells | "abnormal position of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:71710, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mad2l2tm1.1Mpz/Mad2l2tm1.1Mpz Genetic Background: involves: 129S2/SvPas * BALB/cJ
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MP:0008391 | abnormal primordial germ cell morphology | "any structural anomaly of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mad2l2tm1.1Mpz/Mad2l2tm1.1Mpz Genetic Background: involves: 129S2/SvPas * BALB/cJ
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MP:0008392 | decreased primordial germ cell number | "reduced number of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mad2l2tm1Ymu/Mad2l2tm1Ymu Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Mad2l2repro22/Mad2l2repro22 Genetic Background: C3.B6(Cg)-Mad2l2repro22
Allelic Composition: Mad2l2tm1.1Mpz/Mad2l2tm1.1Mpz Genetic Background: involves: 129S2/SvPas * BALB/cJ
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MP:0008393 | absent primordial germ cells | "absence of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mad2l2tm1Ymu/Mad2l2tm1Ymu Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Mad2l2tm1.1Mpz/Mad2l2tm1.1Mpz Genetic Background: involves: 129S2/SvPas * BALB/cJ
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MP:0008489 | postnatal slow weight gain | "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mad2l2tm1.1Mpz/Mad2l2tm1.1Mpz Genetic Background: involves: 129S2/SvPas * BALB/cJ
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MP:0008885 | increased enterocyte apoptosis | "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mad2l2repro22/Mad2l2repro22 Genetic Background: C3.B6(Cg)-Mad2l2repro22
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MP:0009703 | decreased birth body size | "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mad2l2tm1Ymu/Mad2l2tm1Ymu Genetic Background: involves: 129 * C57BL/6J
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MP:0010865 | prenatal growth retardation | "slow or limited development during the prenatal period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mad2l2repro22/Mad2l2repro22 Genetic Background: C3.B6(Cg)-Mad2l2repro22
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MP:0010948 | abnormal double-strand DNA break repair | "any annomaly in the process of repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix" [GO:0006302] |
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Allelic Composition: Mad2l2tm1Ymu/Mad2l2tm1Ymu Genetic Background: involves: 129 * C57BL/6J
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MP:0011102 | partial embryonic lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith] |
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Allelic Composition: Mad2l2repro22/Mad2l2repro22 Genetic Background: C3.B6(Cg)-Mad2l2repro22
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MP:0011112 | partial lethality during fetal growth through weaning | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and weaning age (Mus: E14 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Mad2l2tm1Ymu/Mad2l2tm1Ymu Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Mad2l2tm1.1Mpz/Mad2l2tm1.1Mpz Genetic Background: involves: 129S2/SvPas * BALB/cJ
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MP:0011610 | abnormal primordial germ cell apoptosis | "change in the timing or the number of primordial germ cells undergoing programmed cell death" [MGI:smb] |
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Allelic Composition: Mad2l2tm1Ymu/Mad2l2tm1Ymu Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Mad2l2tm1.1Mpz/Mad2l2tm1.1Mpz Genetic Background: involves: 129S2/SvPas * BALB/cJ
Allelic Composition: Mad2l2tm1Mpz/Mad2l2tm1Mpz,Tg(Prdm1-cre)1Masu/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA
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MP:0012167 | abnormal epigenetic regulation of gene expression | "any anomaly in the process that modulates the frequency, rate or extent of gene expression, in which the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence" [GO:0040029] |
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Allelic Composition: Mad2l2tm1.1Mpz/Mad2l2tm1.1Mpz Genetic Background: involves: 129S2/SvPas * BALB/cJ
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