ENSMUSG00000019841


Mus musculus

Features
Gene ID: ENSMUSG00000019841
  
Biological name :Rev3l
  
Synonyms : DNA polymerase zeta catalytic subunit / Q61493 / Rev3l
  
Possible biological names infered from orthology : O60673 / REV3 like, DNA directed polymerase zeta catalytic subunit
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: B1
Gene start: 39732118
Gene end: 39875211
  
Corresponding Affymetrix probe sets: 10362633 (MoGene1.0st)   1424632_a_at (Mouse Genome 430 2.0 Array)   1426194_x_at (Mouse Genome 430 2.0 Array)   1451960_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000019986
Ensembl peptide - ENSMUSP00000115630
Ensembl peptide - ENSMUSP00000117456
Ensembl peptide - ENSMUSP00000131519
NCBI entrez gene - 19714     See in Manteia.
MGI - MGI:1337131
RefSeq - XM_017313854
RefSeq - NM_011264
RefSeq - XM_006512622
RefSeq - XM_006512623
RefSeq - XM_006512624
RefSeq Peptide - NP_035394
swissprot - F6T1D2
swissprot - Q61493
swissprot - Q9Z281
Ensembl - ENSMUSG00000019841
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rev3lENSDARG00000058801Danio rerio
 REV3LENSGALG00000015033Gallus gallus
 REV3LENSG00000009413Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nexmif / Q5DTT1 / Neurite extension and migration factor / Q5QGS0*ENSMUSG000000464498


Protein motifs (from Interpro)
Interpro ID Name
 IPR006133  DNA-directed DNA polymerase, family B, exonuclease domain
 IPR006134  DNA-directed DNA polymerase, family B, multifunctional domain
 IPR006172  DNA-directed DNA polymerase, family B
 IPR012337  Ribonuclease H-like superfamily
 IPR017964  DNA-directed DNA polymerase, family B, conserved site
 IPR023211  DNA polymerase, palm domain superfamily
 IPR025687  C4-type zinc-finger of DNA polymerase delta
 IPR030559  DNA polymerase zeta catalytic subunit
 IPR032757  Domain of unknown function DUF4683
 IPR036397  Ribonuclease H superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006281 DNA repair IMP
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0019985 translesion synthesis IEA
 biological_processGO:0042276 error-prone translesion synthesis IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0016035 zeta DNA polymerase complex ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003887 DNA-directed DNA polymerase activity IEA
 molecular_functionGO:0008408 3"-5" exonuclease activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051539 4 iron, 4 sulfur cluster binding IEA


Pathways (from Reactome)
Pathway description
Translesion synthesis by REV1
Translesion synthesis by POLK
Translesion synthesis by POLI


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
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Allelic Composition: Hes1tm1Fgu/Hes1+,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001691 abnormal somite shape "atypical characteristic surface configuration of a segmental mass along the notochord of the developing embryo" [J:37888]
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Allelic Composition: Hes1tm1Fgu/Hes1+,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Hes1tm1Fgu/Hes1+,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Rev3ltm1Msn/Rev3ltm1Msn
Genetic Background: Not Specified

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
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Allelic Composition: Hes1tm1Fgu/Hes1+,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Rev3ltm1Kaji/Rev3ltm1Kaji
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: Hes1tm1Fgu/Hes1+,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rev3ltm1Rwd/Rev3ltm2.1Rwd,Trp53tm1Brd/Trp53tm1Brd,Tg(MMTV-cre)1Mam/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Lmx1btm1Rjo/Lmx1btm1Zfc,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

Allelic Composition: Rev3ltm1Rwd/Rev3ltm2.1Rwd,Trp53tm1Brd/Trp53+,Tg(MMTV-cre)1Mam/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rev3ltm1Rwd/Rev3ltm2.1Rwd,Trp53tm1Brd/Trp53tm1Brd,Tg(MMTV-cre)1Mam/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hes1tm1Fgu/Hes1+,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Rev3ltm1Esp/Rev3ltm1Esp
Genetic Background: involves: C57BL/6

Allelic Composition: Rev3ltm1Kaji/Rev3ltm1Kaji
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Rev3ltm1Ndew/Rev3ltm1Ndew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Rev3ltm1Ndew/Rev3ltm1Ndew,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Hes1tm1Fgu/Hes1+,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003789 osteosarcoma "malignant neoplasm derived from bone" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rev3ltm1Rwd/Rev3ltm2.1Rwd,Trp53tm1Brd/Trp53+,Tg(MMTV-cre)1Mam/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0003935 abnormal craniofacial development "anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hes1tm1Fgu/Hes1+,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hes1tm1Fgu/Hes1+,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004029 spontaneous chromosome breakage "chromosome breakage due to inherent instability of chromosomes" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Eef1a1tm1(Kras*)Arge/Eef1a1+,Igf1rtm2Arge/Igf1rtm2Arge,Waptm1(cre)Arge/Wap+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Rev3ltm1Ndew/Rev3ltm1Ndew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004188 delayed embryo turning "completion of axial rotation occurs later than in controls but is eventually completed" [smb:Susan M Bello, Mouse Genome Informatics Curator ""]
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Allelic Composition: Hes1tm1Fgu/Hes1+,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Hes1tm1Fgu/Hes1+,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004815 abnormal somatic hypermutation frequency "any anomaly in the high frequency of programmed mutation that occurs in the gene segments encoding the variable regions of antibodies during the differentiation of individual B lymphocytes into antibody producing plasma cells " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Eef1a1tm1(Kras*)Arge/Eef1a1+,Igf1rtm2Arge/Igf1rtm2Arge,Waptm1(cre)Arge/Wap+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Rev3ltm1.1Diaz/Rev3ltm1.1Diaz,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6NTac

Allelic Composition: Rev3ltm1.1Kunk/Rev3ltm1.1Kunk
Genetic Background: involves: C57BL/6

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Eef1a1tm1(Kras*)Arge/Eef1a1+,Igf1rtm2Arge/Igf1rtm2Arge,Waptm1(cre)Arge/Wap+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Rev3ltm1.1Diaz/Rev3ltm1.1Diaz,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6NTac

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Eef1a1tm1(Kras*)Arge/Eef1a1+,Igf1rtm2Arge/Igf1rtm2Arge,Waptm1(cre)Arge/Wap+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Rev3ltm1.1Diaz/Rev3ltm1.1Diaz,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6NTac

 MP:0006301 abnormal mesenchyme morphology "abnormality in the loosely packed, unspecialized cells that derive mostly from the mesoderm and contribute to connective tissue, bone, cartilage and circulatory and lymphatic systems." [J:120305, mnk:Michelle Knowlton_MGI Curator]
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Allelic Composition: Hes1tm1Fgu/Hes1+,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0008178 decreased germinal center B cell number "reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Eef1a1tm1(Kras*)Arge/Eef1a1+,Igf1rtm2Arge/Igf1rtm2Arge,Waptm1(cre)Arge/Wap+
Genetic Background: involves: 129S1/Sv

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Eef1a1tm1(Kras*)Arge/Eef1a1+,Igf1rtm2Arge/Igf1rtm2Arge,Waptm1(cre)Arge/Wap+
Genetic Background: involves: 129S1/Sv

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lmx1btm1Rjo/Lmx1btm1Zfc,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

Allelic Composition: Rev3ltm1Rwd/Rev3ltm2.1Rwd,Trp53tm1Brd/Trp53+,Tg(MMTV-cre)1Mam/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Rev3ltm1Esp/Rev3ltm1Esp
Genetic Background: involves: C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Hes1tm1Fgu/Hes1+,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Rev3ltm1Kaji/Rev3ltm1Kaji
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Rev3ltm1Msn/Rev3ltm1Msn
Genetic Background: Not Specified

Allelic Composition: Rev3ltm1Ndew/Rev3ltm1Ndew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Rev3ltm1Ndew/Rev3ltm1Ndew,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0012509 neural tube degeneration "a retrogressive impairment of function or destruction of the hollow epithelial tube found on the dorsal side of the vertebrate embryo that develops into the central nervous system (i.e. brain and spinal cord)" [MGI:anna]
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Allelic Composition: Hes1tm1Fgu/Hes1+,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0012556 increased cell death "increased occurrence of the cessation of function at the cellular level" [http://orcid.org/0000-0001-5208-3432]
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Allelic Composition: Hes1tm1Fgu/Hes1+,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Rev3ltm1Kaji/Rev3ltm1Kaji
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / complex / reaction
 ENSMUSG00000027342 Pcna / P17918 / proliferating cell nuclear antigen / P12004*  / complex / reaction
 ENSMUSG00000021668 Polk / Q9QUG2 / polymerase (DNA directed), kappa / Q9UBT6* / DNA polymerase kappa*  / complex / reaction
 ENSMUSG00000038425 Poli / polymerase (DNA directed), iota / Q9UNA4* / DNA polymerase iota*  / reaction / complex
 ENSMUSG00000026082 Rev1 / Q920Q2 / DNA repair protein REV1 / Q9UBZ9* / REV1, DNA directed polymerase*  / reaction / complex
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / complex / reaction
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / reaction / complex
 ENSMUSG00000029003 Mad2l2 / Q9D752 / Mitotic spindle assembly checkpoint protein MAD2B / Q9UI95* / mitotic arrest deficient 2 like 2*  / reaction / complex






 

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