ENSMUSG00000021668


Mus musculus

Features
Gene ID: ENSMUSG00000021668
  
Biological name :Polk
  
Synonyms : Polk / polymerase (DNA directed), kappa / Q9QUG2
  
Possible biological names infered from orthology : DNA polymerase kappa / Q9UBT6
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: D1
Gene start: 96480690
Gene end: 96542579
  
Corresponding Affymetrix probe sets: 10411306 (MoGene1.0st)   1419501_at (Mouse Genome 430 2.0 Array)   1449483_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152468
Ensembl peptide - ENSMUSP00000152647
Ensembl peptide - ENSMUSP00000152658
Ensembl peptide - ENSMUSP00000022172
Ensembl peptide - ENSMUSP00000088950
Ensembl peptide - ENSMUSP00000152139
Ensembl peptide - ENSMUSP00000152178
Ensembl peptide - ENSMUSP00000152192
Ensembl peptide - ENSMUSP00000152322
NCBI entrez gene - 27015     See in Manteia.
MGI - MGI:1349767
RefSeq - NM_012048
RefSeq - XM_006517679
RefSeq - XM_006517680
RefSeq Peptide - NP_001334531
RefSeq Peptide - NP_036178
swissprot - Q5Q9H5
swissprot - Q5Q9H6
swissprot - Q5Q9H7
swissprot - Q9QUG2
swissprot - Q5Q9H4
swissprot - A0A1Y7VIV8
swissprot - Q5Q9H0
swissprot - Q5Q9H3
swissprot - A0A1Y7VJV3
Ensembl - ENSMUSG00000021668
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 polkENSDARG00000059963Danio rerio
 POLKENSGALG00000014956Gallus gallus
 POLKENSG00000122008Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rev1 / Q920Q2 / DNA repair protein REV1 / Q9UBZ9* / REV1, DNA directed polymerase*ENSMUSG0000002608217
Poli / polymerase (DNA directed), iota / Q9UNA4* / DNA polymerase iota*ENSMUSG0000003842516
Polh / Q9JJN0 / DNA polymerase eta / Q9Y253*ENSMUSG0000002395315


Protein motifs (from Interpro)
Interpro ID Name
 IPR001126  UmuC domain
 IPR006642  Zinc finger, Rad18-type putative
 IPR017061  DNA polymerase eta/kappa/iota/IV
 IPR017961  DNA polymerase, Y-family, little finger domain
 IPR022880  DNA polymerase IV
 IPR036775  DNA polymerase, Y-family, little finger domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006297 nucleotide-excision repair, DNA gap filling IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0034644 cellular response to UV IEA
 biological_processGO:0042276 error-prone translesion synthesis IEA
 biological_processGO:0071897 DNA biosynthetic process IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0090734 site of DNA damage IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0003887 DNA-directed DNA polymerase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Translesion synthesis by POLK
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
Show

Allelic Composition: Slc10a2tm1Pda/Slc10a2tm1Pda
Genetic Background: either: B6.129P2-Slc10a2tm1Pda or (involves: 129P2/OlaHsd * C57BL/6J)

 MP:0008410 increased cellular sensitivity to ultraviolet irradiation "greater incidence of cell death following exposure to ultraviolet irradiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc10a2tm1Pda/Slc10a2tm1Pda
Genetic Background: either: B6.129P2-Slc10a2tm1Pda or (involves: 129P2/OlaHsd * C57BL/6J)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / complex / reaction
 ENSMUSG00000019841 Rev3l / Q61493 / DNA polymerase zeta catalytic subunit / O60673* / REV3 like, DNA directed polymerase zeta catalytic subunit*  / complex / reaction
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / complex / reaction
 ENSMUSG00000000275 Q61510 / Trim25 / E3 ubiquitin/ISG15 ligase TRIM25 / Q14258* / tripartite motif containing 25*  / complex / reaction
 ENSMUSG00000035692 Isg15 / Q64339 / Ubiquitin-like protein ISG15 / P05161* / ISG15 ubiquitin-like modifier*  / reaction
 ENSMUSG00000027342 Pcna / P17918 / proliferating cell nuclear antigen / P12004*  / complex / reaction
 ENSMUSG00000032596 Uba7 / ubiquitin-like modifier activating enzyme 7 / P41226*  / reaction
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / complex / reaction
 ENSMUSG00000027078 Q9QZU9 / Ube2l6 / ubiquitin-conjugating enzyme E2L 6 / O14933*  / reaction / complex
 ENSMUSG00000026082 Rev1 / Q920Q2 / DNA repair protein REV1 / Q9UBZ9* / REV1, DNA directed polymerase*  / complex / reaction
 ENSMUSG00000029003 Mad2l2 / Q9D752 / Mitotic spindle assembly checkpoint protein MAD2B / Q9UI95* / mitotic arrest deficient 2 like 2*  / complex / reaction






 

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