ENSDARG00000059963


Danio rerio

Features
Gene ID: ENSDARG00000059963
  
Biological name :polk
  
Synonyms : polk / polymerase (DNA directed) kappa
  
Possible biological names infered from orthology : DNA polymerase kappa / Q9QUG2 / Q9UBT6
  
Species: Danio rerio
  
Chr. number: 5
Strand: 1
Band:
Gene start: 45895613
Gene end: 45914457
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000078372
Ensembl peptide - ENSDARP00000112656
NCBI entrez gene - 562749     See in Manteia.
swissprot - B0S5R3
swissprot - E7F6Y7
ZFIN ID - ZDB-GENE-060526-137
Ensembl - ENSDARG00000059963
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 POLKENSGALG00000014956Gallus gallus
 POLKENSG00000122008Homo sapiens
 PolkENSMUSG00000021668Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rev1 / REV1, polymerase (DNA directed) / Q9UBZ9* / Q920Q2* / DNA repair protein REV1 * / REV1, DNA directed polymerase*ENSDARG0000001829617
poli / polymerase (DNA directed) iota / Q9UNA4* / DNA polymerase iota*ENSDARG0000002925016
polh / polymerase (DNA directed), eta / Q9JJN0* / Q9Y253* / DNA polymerase eta*ENSDARG0000007023113


Protein motifs (from Interpro)
Interpro ID Name
 IPR001126  UmuC domain
 IPR006642  Zinc finger, Rad18-type putative
 IPR017061  DNA polymerase eta/kappa/iota/IV
 IPR017961  DNA polymerase, Y-family, little finger domain
 IPR022880  DNA polymerase IV


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0071897 DNA biosynthetic process IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0003887 DNA-directed DNA polymerase activity IEA


Pathways (from Reactome)
Pathway description
Translesion synthesis by POLK
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000003938 rpa1 / Q6NY74 / replication protein A1 / Q8VEE4* / P27694* / Replication protein A 70 kDa DNA-binding subunit *  / complex / reaction
 ENSDARG00000042456 MAD2L2 / Q568H3 / zgc:110299 / Q9D752* / Q9UI95* / mitotic arrest deficient 2 like 2* / Mitotic spindle assembly checkpoint protein MAD2B *  / complex / reaction
 ENSDARG00000058801 rev3l / REV3-like, polymerase (DNA directed), zeta, catalytic subunit / Q61493* / O60673* / DNA polymerase zeta catalytic subunit * / REV3 like, DNA directed polymerase zeta catalytic subunit*  / complex / reaction
 ENSDARG00000037188 rpa2 / replication protein A2 / RPA4* / Q13156* / P15927* / replication protein A4*  / complex / reaction
 ENSDARG00000054155 pcna / Q9PTP1 / proliferating cell nuclear antigen / P17918* / P12004* / Pcna-ps2*  / complex / reaction
 ENSDARG00000018296 rev1 / REV1, polymerase (DNA directed) / Q9UBZ9* / Q920Q2* / DNA repair protein REV1 * / REV1, DNA directed polymerase*  / complex / reaction






 

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