ENSDARG00000054155


Danio rerio

Features
Gene ID: ENSDARG00000054155
  
Biological name :pcna
  
Synonyms : pcna / proliferating cell nuclear antigen / Q9PTP1
  
Possible biological names infered from orthology : P12004 / P17918 / Pcna-ps2
  
Species: Danio rerio
  
Chr. number: 10
Strand: -1
Band:
Gene start: 40821804
Gene end: 40826657
  
Corresponding Affymetrix probe sets: Dr.1348.1.S1_at (Zebrafish Array)   NM_131404_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000070780
NCBI entrez gene - 30678     See in Manteia.
RefSeq - NM_131404
RefSeq Peptide - NP_571479
swissprot - Q9PTP1
ZFIN ID - ZDB-GENE-000210-8
Ensembl - ENSDARG00000054155
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PCNAENSGALG00000029292Gallus gallus
 PCNAENSG00000132646Homo sapiens
 PcnaENSMUSG00000027342Mus musculus
 Pcna-ps2ENSMUSG00000067608Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000730  Proliferating cell nuclear antigen, PCNA
 IPR022648  Proliferating cell nuclear antigen, PCNA, N-terminal
 IPR022649  Proliferating cell nuclear antigen, PCNA, C-terminal
 IPR022659  Proliferating cell nuclear antigen, PCNA, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006272 leading strand elongation IBA
 biological_processGO:0006275 regulation of DNA replication IEA
 biological_processGO:0006298 mismatch repair IBA
 biological_processGO:0009617 response to bacterium IDA
 biological_processGO:0014823 response to activity IDA
 biological_processGO:0019985 translesion synthesis IBA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0043626 PCNA complex IBA
 cellular_componentGO:0070557 PCNA-p21 complex ISS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0030337 DNA polymerase processivity factor activity IBA


Pathways (from Reactome)
Pathway description
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Removal of the Flap Intermediate from the C-strand
SUMOylation of DNA replication proteins
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000003749 polb / polymerase (DNA directed), beta / P06746* / Q8K409* / DNA polymerase beta*  / reaction
 ENSDARG00000052721 prim2 / DNA primase subunit 2 / P33610* / P49643* / DNA primase large subunit *  / complex / reaction
 ENSDARG00000011404 fen1 / Q6TNU4 / flap structure-specific endonuclease 1 / P39748*  / complex / reaction
 ENSDARG00000015070 pola2 / polymerase (DNA directed), alpha 2 / P33611* / Q14181* / DNA polymerase alpha 2, accessory subunit*  / complex / reaction
 ENSDARG00000003938 rpa1 / Q6NY74 / replication protein A1 / Q8VEE4* / P27694* / Replication protein A 70 kDa DNA-binding subunit *  / reaction / complex
 ENSDARG00000029250 poli / polymerase (DNA directed) iota / Q9UNA4* / DNA polymerase iota*  / complex / reaction
 ENSDARG00000027689 pold1 / polymerase (DNA directed), delta 1, catalytic subunit / P28340* / P52431* / DNA polymerase delta 1, catalytic subunit*  / reaction / complex
 ENSDARG00000059963 polk / polymerase (DNA directed) kappa / Q9QUG2* / Q9UBT6* / DNA polymerase kappa*  / complex / reaction
 ENSDARG00000037188 rpa2 / replication protein A2 / RPA4* / Q13156* / P15927* / replication protein A4*  / complex / reaction
 ENSDARG00000042456 MAD2L2 / Q568H3 / zgc:110299 / Q9D752* / Q9UI95* / mitotic arrest deficient 2 like 2* / Mitotic spindle assembly checkpoint protein MAD2B *  / complex / reaction
 ENSDARG00000060041 lig1 / ligase I, DNA, ATP-dependent / P18858* / DNA ligase 1*  / complex / reaction
 ENSDARG00000038030 rbx1 / ring-box 1, E3 ubiquitin protein ligase / P62878* / P62877* / ring-box 1* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / reaction / complex
 ENSDARG00000078759 dna2 / DNA replication helicase/nuclease 2 / P51530* / Q6ZQJ5* / DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2*  / complex / reaction
 ENSDARG00000023002 dtl / Q5RHI5 / denticleless E3 ubiquitin protein ligase homolog (Drosophila) / Q9NZJ0* / Q3TLR7* / Denticleless protein homolog * / denticleless E3 ubiquitin protein ligase homolog*  / reaction / complex
 ENSDARG00000104571 gadd45ab / growth arrest and DNA-damage-inducible, alpha, b / P24522* / P48316* / GADD45A* / growth arrest and DNA damage inducible alpha* / Growth arrest and DNA damage-inducible protein G...  / complex / reaction
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / reaction / complex
 ENSDARG00000052649 Q9DDJ0 / ube2ia / ubiquitin-conjugating enzyme E2Ia / UBE2I* / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000104709 sprtn / SprT-like N-terminal domain / Q9H040*  / reaction / complex
 ENSDARG00000008748 ube2na / ubiquitin-conjugating enzyme E2Na / UBE2N* / P61089* / UBE2NL* / P61088* / ubiquitin conjugating enzyme E2 N* / ubiquitin conjugating enzyme E2 N like (gene/pseudogene)*  / complex
 ENSDARG00000045308 pola1 / polymerase (DNA directed), alpha 1 / P09884* / P33609* / DNA polymerase alpha 1, catalytic subunit*  / reaction / complex
 ENSDARG00000079632 si:dkey-28b4.7 / POLD4* / Q9CWP8* / Q9HCU8* / AP003419.1* / polymerase (DNA-directed), delta 4* / DNA polymerase delta 4, accessory subunit*  / reaction / complex
 ENSDARG00000018296 rev1 / REV1, polymerase (DNA directed) / Q9UBZ9* / Q920Q2* / DNA repair protein REV1 * / REV1, DNA directed polymerase*  / complex / reaction
 ENSDARG00000038543 wdr48b / Q6PFM9 / WD repeat domain 48b / WDR48* / Q8TAF3* / Q8BH57* / WD repeat domain 48*  / reaction / complex
 ENSDARG00000075672 pms2 / PMS1 homolog 2, mismatch repair system component / P54278* / Gm42421*  / complex / reaction
 ENSDARG00000045877 ube2nb / ubiquitin-conjugating enzyme E2Nb / UBE2N* / P61089* / UBE2NL* / P61088* / ubiquitin conjugating enzyme E2 N* / ubiquitin conjugating enzyme E2 N like (gene/pseudogene)*  / complex
 ENSDARG00000058801 rev3l / REV3-like, polymerase (DNA directed), zeta, catalytic subunit / Q61493* / O60673* / DNA polymerase zeta catalytic subunit * / REV3 like, DNA directed polymerase zeta catalytic subunit*  / complex / reaction
 ENSDARG00000028198 Q6PEH5 / ube2v2 / ubiquitin-conjugating enzyme E2 variant 2 / Q15819* / ubiquitin conjugating enzyme E2 V2*  / complex
 ENSDARG00000043581 gadd45aa / growth arrest and DNA-damage-inducible, alpha, a / P24522* / P48316* / GADD45A* / growth arrest and DNA damage inducible alpha* / Growth arrest and DNA damage-inducible protein G...  / reaction / complex
 ENSDARG00000060510 cul4b / cullin 4B / A2A432* / Q13620*  / complex / reaction
 ENSDARG00000100487 nploc4 / NPL4 homolog, ubiquitin recognition factor / Q8TAT6*  / reaction / complex
 ENSDARG00000054155 pcna / Q9PTP1 / proliferating cell nuclear antigen / P17918* / P12004* / Pcna-ps2*  / complex
 ENSDARG00000086374 isg15 / ISG15 ubiquitin-like modifier / P05161* / Q64339* / Ubiquitin-like protein ISG15 *  / complex
 ENSDARG00000020008 vcp / Q7ZU99 / valosin containing protein / P55072* / Q01853*  / complex / reaction
 ENSDARG00000096578 cul4a / cullin 4A / Q13619* / Q3TCH7*  / complex / reaction
 ENSDARG00000010051 ufd1l / ubiquitin recognition factor in ER associated degradation 1 / UFD1* / P70362* / Q92890*  / reaction / complex
 ENSDARG00000007438 ube2ib / Q9W6H5 / ubiquitin-conjugating enzyme E2Ib / UBE2I* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000070231 polh / polymerase (DNA directed), eta / Q9JJN0* / Q9Y253* / DNA polymerase eta*  / complex / reaction
 ENSDARG00000088072 usp43b / ubiquitin specific peptidase 43b / USP43* / Q70EL4* / Q8BUM9* / ubiquitin specific peptidase 43*  / complex / reaction
 ENSDARG00000026053 hltf / helicase-like transcription factor / Q14527* / Q6PCN7*  / complex
 ENSDARG00000075884 shprh / SNF2 histone linker PHD RING helicase / Q149N8* / Q7TPQ3* / E3 ubiquitin-protein ligase SHPRH *  / complex
 ENSDARG00000103494 usp43a / ubiquitin specific peptidase 43a / USP43* / Q70EL4* / Q8BUM9* / ubiquitin specific peptidase 43*  / reaction / complex






 

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