ENSDARG00000020008


Danio rerio

Features
Gene ID: ENSDARG00000020008
  
Biological name :vcp
  
Synonyms : Q7ZU99 / valosin containing protein / vcp
  
Possible biological names infered from orthology : P55072 / Q01853
  
Species: Danio rerio
  
Chr. number: 5
Strand: 1
Band:
Gene start: 41510387
Gene end: 41520980
  
Corresponding Affymetrix probe sets: Dr.25189.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000012048
NCBI entrez gene - 327197     See in Manteia.
swissprot - Q7ZU99
ZFIN ID - ZDB-GENE-030131-5408
Ensembl - ENSDARG00000020008
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 VCPENSGALG00000001986Gallus gallus
 VCPENSG00000165280Homo sapiens
 VcpENSMUSG00000028452Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
zgc:136908ENSDARG0000001198385


Protein motifs (from Interpro)
Interpro ID Name
 IPR003338  CDC48, N-terminal subdomain
 IPR003593  AAA+ ATPase domain
 IPR003959  ATPase, AAA-type, core
 IPR003960  ATPase, AAA-type, conserved site
 IPR004201  CDC48, domain 2
 IPR005938  AAA ATPase, CDC48 family
 IPR009010  Aspartate decarboxylase-like domain superfamily
 IPR015415  Vps4 oligomerisation, C-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR029067  CDC48 domain 2-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair ISS
 biological_processGO:0006914 autophagy ISS
 biological_processGO:0006974 cellular response to DNA damage stimulus ISS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0016236 macroautophagy ISS
 biological_processGO:0016567 protein ubiquitination ISS
 biological_processGO:0018279 protein N-linked glycosylation via asparagine ISS
 biological_processGO:0019985 translesion synthesis ISS
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway ISS
 biological_processGO:0032510 endosome to lysosome transport via multivesicular body sorting pathway ISS
 biological_processGO:0036503 ERAD pathway ISS
 biological_processGO:0043009 chordate embryonic development IMP
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0097352 autophagosome maturation ISS
 biological_processGO:2000058 regulation of ubiquitin-dependent protein catabolic process IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0035861 site of double-strand break ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity ISS


Pathways (from Reactome)
Pathway description
Translesion Synthesis by POLH
HSF1 activation
ABC-family proteins mediated transport
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Hedgehog ligand biogenesis
Josephin domain DUBs
Ovarian tumor domain proteases
Neutrophil degranulation
Protein methylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain apoptotic , abnormal
brain degeneration , abnormal
Show

 ZFA:0000024 retinal ganglion cell layer retinal ganglion cell layer neuron degenerate , abnormal
retinal ganglion cell layer decayed , abnormal
Show

 ZFA:0000101 diencephalon diencephalon nucleus aggregated , abnormal
diencephalon apoptotic , abnormal
diencephalon cell decreased amount , abnormal
Show

 ZFA:0000107 eye eye apoptotic , abnormal
eye nucleus aggregated , abnormal
eye size , abnormal
eye degeneration , abnormal
Show

 ZFA:0000435 cranial nerve II cranial nerve II decreased width , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased mobility , abnormal
Show

 ZFA:0001114 head head size , abnormal
Show

 ZFA:0001115 trunk trunk curved ventral , abnormal
Show

 ZFA:0001329 retinal inner plexiform layer retinal inner plexiform layer neuron degenerate , abnormal
retinal inner plexiform layer decayed , abnormal
Show

 ZFA:0009052 motor neuron motor neuron axon branched , abnormal
motor neuron axon truncated , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000004581 sel1l / sel-1 suppressor of lin-12-like (C. elegans) / Q9UBV2* / Q9Z2G6* / SEL1L ERAD E3 ligase adaptor subunit*  / complex
 ENSDARG00000008384 hdac6 / histone deacetylase 6 / Q9UBN7* / Q9Z2V5*  / complex
 ENSDARG00000099274 atxn3 / ataxin 3 / ATXN3L* / Q9H3M9* / P54252* / ataxin 3 like*  / reaction / complex
 ENSDARG00000010051 ufd1l / ubiquitin recognition factor in ER associated degradation 1 / UFD1* / P70362* / Q92890*  / complex
 ENSDARG00000100487 nploc4 / NPL4 homolog, ubiquitin recognition factor / Q8TAT6*  / complex
 ENSDARG00000020008 vcp / Q7ZU99 / valosin containing protein / P55072* / Q01853*  / complex
 ENSDARG00000008542 yod1 / Q567B1 / YOD1 deubiquitinase / Q5VVQ6* / Q8CB27*  / reaction / complex
 ENSDARG00000003938 rpa1 / Q6NY74 / replication protein A1 / Q8VEE4* / P27694* / Replication protein A 70 kDa DNA-binding subunit *  / complex / reaction
 ENSDARG00000037188 rpa2 / replication protein A2 / RPA4* / Q13156* / P15927* / replication protein A4*  / reaction / complex
 ENSDARG00000054155 pcna / Q9PTP1 / proliferating cell nuclear antigen / P17918* / P12004* / Pcna-ps2*  / reaction / complex
 ENSDARG00000042401 derl2 / derlin 2 / Q9GZP9*  / complex
 ENSDARG00000070231 polh / polymerase (DNA directed), eta / Q9JJN0* / Q9Y253* / DNA polymerase eta*  / reaction / complex
 ENSDARG00000060021 vcpkmt / valosin containing protein lysine (K) methyltransferase / Q8C436* / Q9H867* / valosin containing protein lysine methyltransferase*  / reaction
 ENSDARG00000017842 syvn1 / synovial apoptosis inhibitor 1, synoviolin / Q86TM6* / synoviolin 1*  / complex
 ENSDARG00000104709 sprtn / SprT-like N-terminal domain / Q9H040*  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr