ENSDARG00000003938


Danio rerio

Features
Gene ID: ENSDARG00000003938
  
Biological name :rpa1
  
Synonyms : Q6NY74 / replication protein A1 / rpa1
  
Possible biological names infered from orthology : P27694 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit
  
Species: Danio rerio
  
Chr. number: 15
Strand: -1
Band:
Gene start: 26498339
Gene end: 26538989
  
Corresponding Affymetrix probe sets: Dr.7625.1.S1_at (Zebrafish Array)   NM_199811_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000029067
NCBI entrez gene - 327491     See in Manteia.
RefSeq - NM_199811
RefSeq Peptide - NP_956105
swissprot - Q6NY74
ZFIN ID - ZDB-GENE-030912-3
Ensembl - ENSDARG00000003938
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RPA1ENSGALG00000003072Gallus gallus
 RPA1ENSG00000132383Homo sapiens
 Rpa1ENSMUSG00000000751Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004365  OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
 IPR004591  Replication factor A protein 1
 IPR007199  Replication factor-A protein 1, N-terminal
 IPR012340  Nucleic acid-binding, OB-fold
 IPR013955  Replication factor A, C-terminal
 IPR031657  Replication protein A, OB domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication ISS
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0034502 protein localization to chromosome ISS
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005662 DNA replication factor A complex ISS
 cellular_componentGO:0016605 PML body IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding ISS
 molecular_functionGO:0003697 single-stranded DNA binding ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Removal of the Flap Intermediate from the C-strand
Activation of ATR in response to replication stress
SUMOylation of DNA damage response and repair proteins
Regulation of HSF1-mediated heat shock response
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Fanconi Anemia Pathway
Regulation of TP53 Activity through Phosphorylation
Activation of the pre-replicative complex
Removal of the Flap Intermediate
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain necrotic , abnormal
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 ZFA:0000012 central nervous system central nervous system necrotic , abnormal
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 ZFA:0000114 heart heart necrotic , abnormal
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 ZFA:0001094 whole organism whole organism viability , abnormal
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 ZFA:0001114 head head flat , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000003749 polb / polymerase (DNA directed), beta / P06746* / Q8K409* / DNA polymerase beta*  / reaction
 ENSDARG00000011404 fen1 / Q6TNU4 / flap structure-specific endonuclease 1 / P39748*  / reaction / complex
 ENSDARG00000023584 cdc7 / cell division cycle 7 homolog (S. cerevisiae) / Q9Z0H0* / O00311* / cell division cycle 7* / Cell division cycle 7-related protein kinase *  / complex / reaction
 ENSDARG00000026577 cdk2 / cyclin-dependent kinase 2 / P24941* / P97377*  / complex / reaction
 ENSDARG00000023678 ercc5 / excision repair cross-complementation group 5 / P28715* / ERCC excision repair 5, endonuclease*  / complex / reaction
 ENSDARG00000045308 pola1 / polymerase (DNA directed), alpha 1 / P09884* / P33609* / DNA polymerase alpha 1, catalytic subunit*  / reaction / complex
 ENSDARG00000040559 rad1 / RAD1 homolog (S. pombe) / Q9QWZ1* / O60671* / RAD1 checkpoint DNA exonuclease* / Cell cycle checkpoint protein RAD1 *  / reaction / complex
 ENSDARG00000103137 rmi2 / RecQ mediated genome instability 2 / Q3UPE3* / Q96E14* / RecQ-mediated genome instability protein 2 *  / complex / reaction
 ENSDARG00000056984 rad9a / RAD9 checkpoint clamp component A / Q99638* / Q9Z0F6* / Cell cycle checkpoint control protein RAD9A *  / complex / reaction
 ENSDARG00000038543 wdr48b / Q6PFM9 / WD repeat domain 48b / WDR48* / Q8TAF3* / Q8BH57* / WD repeat domain 48*  / reaction / complex
 ENSDARG00000052827 top3a / DNA topoisomerase III alpha / O70157* / Q13472* / topoisomerase (DNA) III alpha*  / reaction / complex
 ENSDARG00000098211 wrn / Werner syndrome / O09053* / Q14191* / Werner syndrome RecQ like helicase*  / reaction / complex
 ENSDARG00000052649 Q9DDJ0 / ube2ia / ubiquitin-conjugating enzyme E2Ia / UBE2I* / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000063076 atrip / ATR interacting protein / Q8BMG1* / Q8WXE1*  / reaction / complex
 ENSDARG00000028119 Q6NV25 / sumo3a / small ubiquitin-like modifier 3a / SUMO3* / Q9Z172* / P55854* / small ubiquitin-like modifier 3*  / reaction
 ENSDARG00000086374 isg15 / ISG15 ubiquitin-like modifier / P05161* / Q64339* / Ubiquitin-like protein ISG15 *  / complex
 ENSDARG00000078759 dna2 / DNA replication helicase/nuclease 2 / P51530* / Q6ZQJ5* / DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2*  / complex / reaction
 ENSDARG00000023002 dtl / Q5RHI5 / denticleless E3 ubiquitin protein ligase homolog (Drosophila) / Q9NZJ0* / Q3TLR7* / Denticleless protein homolog * / denticleless E3 ubiquitin protein ligase homolog*  / reaction / complex
 ENSDARG00000029250 poli / polymerase (DNA directed) iota / Q9UNA4* / DNA polymerase iota*  / reaction / complex
 ENSDARG00000038917 rad50 / RAD50 homolog, double strand break repair protein / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / reaction / complex
 ENSDARG00000079632 si:dkey-28b4.7 / POLD4* / Q9CWP8* / Q9HCU8* / AP003419.1* / polymerase (DNA-directed), delta 4* / DNA polymerase delta 4, accessory subunit*  / complex / reaction
 ENSDARG00000026224 fanci / Fanconi anemia, complementation group I / Q8K368* / Q9NVI1* / Fanconi anemia group I protein homolog *  / reaction / complex
 ENSDARG00000059963 polk / polymerase (DNA directed) kappa / Q9QUG2* / Q9UBT6* / DNA polymerase kappa*  / complex / reaction
 ENSDARG00000042456 MAD2L2 / Q568H3 / zgc:110299 / Q9D752* / Q9UI95* / mitotic arrest deficient 2 like 2* / Mitotic spindle assembly checkpoint protein MAD2B *  / reaction / complex
 ENSDARG00000018296 rev1 / REV1, polymerase (DNA directed) / Q9UBZ9* / Q920Q2* / DNA repair protein REV1 * / REV1, DNA directed polymerase*  / complex / reaction
 ENSDARG00000002385 atm / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / complex / reaction
 ENSDARG00000052721 prim2 / DNA primase subunit 2 / P33610* / P49643* / DNA primase large subunit *  / complex / reaction
 ENSDARG00000104709 sprtn / SprT-like N-terminal domain / Q9H040*  / reaction / complex
 ENSDARG00000040303 nbn / nibrin / Q5I2W8 / O60934* / Q9R207*  / complex / reaction
 ENSDARG00000038030 rbx1 / ring-box 1, E3 ubiquitin protein ligase / P62878* / P62877* / ring-box 1* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / reaction / complex
 ENSDARG00000105014 mre11a / MRE11 homolog A, double strand break repair nuclease / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / reaction / complex
 ENSDARG00000035993 sumo3b / small ubiquitin-like modifier 3b / SUMO3* / P55854* / small ubiquitin-like modifier 3*  / reaction
 ENSDARG00000060510 cul4b / cullin 4B / A2A432* / Q13620*  / complex / reaction
 ENSDARG00000054155 pcna / Q9PTP1 / proliferating cell nuclear antigen / P17918* / P12004* / Pcna-ps2*  / reaction / complex
 ENSDARG00000100487 nploc4 / NPL4 homolog, ubiquitin recognition factor / Q8TAT6*  / reaction / complex
 ENSDARG00000102741 sumo2b / Q6DHL4 / small ubiquitin-like modifier 2b / SUMO4* / SUMO2* / Q6EEV6* / P61956* / P61957* / small ubiquitin-like modifier 4* / small ubiquitin-like modifier 2*  / reaction
 ENSDARG00000053574 fancd2 / Fanconi anemia, complementation group D2 / Q80V62* / Q9BXW9* / Fanconi anemia group D2 protein homolog *  / reaction / complex
 ENSDARG00000008818 hsf1 / heat shock transcription factor 1 / P38532* / Q00613* / heat shock factor 1*  / complex / reaction
 ENSDARG00000037188 rpa2 / replication protein A2 / RPA4* / Q13156* / P15927* / replication protein A4*  / complex
 ENSDARG00000074410 brip1 / BRCA1 interacting protein C-terminal helicase 1 / Q5SXJ3* / Q9BX63* / Fanconi anemia group J protein homolog *  / complex / reaction
 ENSDARG00000096578 cul4a / cullin 4A / Q13619* / Q3TCH7*  / complex / reaction
 ENSDARG00000027689 pold1 / polymerase (DNA directed), delta 1, catalytic subunit / P28340* / P52431* / DNA polymerase delta 1, catalytic subunit*  / complex / reaction
 ENSDARG00000010051 ufd1l / ubiquitin recognition factor in ER associated degradation 1 / UFD1* / P70362* / Q92890*  / reaction / complex
 ENSDARG00000070231 polh / polymerase (DNA directed), eta / Q9JJN0* / Q9Y253* / DNA polymerase eta*  / complex / reaction
 ENSDARG00000020008 vcp / Q7ZU99 / valosin containing protein / P55072* / Q01853*  / complex / reaction
 ENSDARG00000043480 rbbp8 / F1R983 / retinoblastoma binding protein 8 / Q80YR6* / Q99708* / RB binding protein 8, endonuclease* / retinoblastoma binding protein 8, endonuclease*  / complex / reaction
 ENSDARG00000031680 ercc1 / excision repair cross-complementation group 1 / P07992* / P07903* / DNA excision repair protein ERCC-1 * / ERCC excision repair 1, endonuclease non-catalytic subunit*  / reaction / complex
 ENSDARG00000007438 ube2ib / Q9W6H5 / ubiquitin-conjugating enzyme E2Ib / UBE2I* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000058801 rev3l / REV3-like, polymerase (DNA directed), zeta, catalytic subunit / Q61493* / O60673* / DNA polymerase zeta catalytic subunit * / REV3 like, DNA directed polymerase zeta catalytic subunit*  / complex / reaction
 ENSDARG00000015070 pola2 / polymerase (DNA directed), alpha 2 / P33611* / Q14181* / DNA polymerase alpha 2, accessory subunit*  / reaction / complex
 ENSDARG00000075632 rad9b / RAD9 checkpoint clamp component B / Q6WBX7* / Q6WBX8*  / reaction / complex
 ENSDARG00000026540 ppp4r2a / protein phosphatase 4, regulatory subunit 2a / PPP4R2* / Q9NY27* / protein phosphatase 4 regulatory subunit 2*  / reaction
 ENSDARG00000045815 mcm10 / Q5RHY1 / minichromosome maintenance 10 replication initiation factor / Q0VBD2* / Q7L590*  / reaction / complex
 ENSDARG00000060041 lig1 / ligase I, DNA, ATP-dependent / P18858* / DNA ligase 1*  / complex / reaction
 ENSDARG00000043720 cdc45 / CDC45 cell division cycle 45 homolog (S. cerevisiae) / O75419* / Q9Z1X9* / cell division cycle 45* / Cell division control *  / complex / reaction
 ENSDARG00000053447 A1L1M4 / ppp4r2b / protein phosphatase 4, regulatory subunit 2b / PPP4R2* / Q9NY27* / protein phosphatase 4 regulatory subunit 2*  / reaction
 ENSDARG00000074796 dbf4 / DBF4 zinc finger / A * / Q9QZ41* / Q9UBU7*  / reaction / complex
 ENSDARG00000070570 ppp4ca / A8WGP3 / protein phosphatase 4, catalytic subunit a / PPP4C* / P97470* / P60510* / protein phosphatase 4 catalytic subunit*  / reaction
 ENSDARG00000088072 usp43b / ubiquitin specific peptidase 43b / USP43* / Q70EL4* / Q8BUM9* / ubiquitin specific peptidase 43*  / reaction / complex
 ENSDARG00000076439 ppp4cb / A9JRC7 / protein phosphatase 4, catalytic subunit b / PPP4C* / P97470* / P60510* / protein phosphatase 4 catalytic subunit*  / reaction
 ENSDARG00000103494 usp43a / ubiquitin specific peptidase 43a / USP43* / Q70EL4* / Q8BUM9* / ubiquitin specific peptidase 43*  / reaction / complex






 

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