ENSDARG00000074410


Danio rerio

Features
Gene ID: ENSDARG00000074410
  
Biological name :brip1
  
Synonyms : BRCA1 interacting protein C-terminal helicase 1 / brip1
  
Possible biological names infered from orthology : Fanconi anemia group J protein homolog / Q5SXJ3 / Q9BX63
  
Species: Danio rerio
  
Chr. number: 15
Strand: -1
Band:
Gene start: 27415772
Gene end: 27522838
  
Corresponding Affymetrix probe sets: Dr.15442.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000156330
Ensembl peptide - ENSDARP00000157362
Ensembl peptide - ENSDARP00000102913
Ensembl peptide - ENSDARP00000124530
Ensembl peptide - ENSDARP00000146170
Ensembl peptide - ENSDARP00000149459
Ensembl peptide - ENSDARP00000152216
Ensembl peptide - ENSDARP00000155228
NCBI entrez gene - 794038     See in Manteia.
RefSeq - XM_021481483
RefSeq Peptide - NP_001103766
swissprot - B7ZDD5
swissprot - F8W319
ZFIN ID - ZDB-GENE-081107-11
Ensembl - ENSDARG00000074410
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BRIP1ENSGALG00000005279Gallus gallus
 BRIP1ENSG00000136492Homo sapiens
 Brip1ENSMUSG00000034329Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rtel1 / regulator of telomere elongation helicase 1 / Q9NZ71* / Q0VGM9* / RTEL1-TNFRSF6B* / RTEL1-TNFRSF6B readthrough (NMD candidate)*ENSDARG0000003507421
ddx11 / F1R345 / DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 / Q6AXC6* / Q96FC9* / DEAD/H-box helicase 11* / Mus musculus DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 (Ddx11), transcript v...ENSDARG0000001107217


Protein motifs (from Interpro)
Interpro ID Name
 IPR006554  Helicase-like, DEXD box c2 type
 IPR006555  ATP-dependent helicase, C-terminal
 IPR010614  DEAD2
 IPR013020  ATP-dependent helicase Rad3/Chl1-like
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014013  Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006139 nucleobase-containing compound metabolic process IEA
 biological_processGO:0032508 DNA duplex unwinding IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004003 ATP-dependent DNA helicase activity IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008026 ATP-dependent helicase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA


Pathways (from Reactome)
Pathway description
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000003938 rpa1 / Q6NY74 / replication protein A1 / Q8VEE4* / P27694* / Replication protein A 70 kDa DNA-binding subunit *  / reaction / complex
 ENSDARG00000037188 rpa2 / replication protein A2 / RPA4* / Q13156* / P15927* / replication protein A4*  / complex / reaction
 ENSDARG00000063076 atrip / ATR interacting protein / Q8BMG1* / Q8WXE1*  / complex / reaction
 ENSDARG00000103137 rmi2 / RecQ mediated genome instability 2 / Q3UPE3* / Q96E14* / RecQ-mediated genome instability protein 2 *  / complex / reaction
 ENSDARG00000002385 atm / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / complex / reaction
 ENSDARG00000105014 mre11a / MRE11 homolog A, double strand break repair nuclease / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / reaction / complex
 ENSDARG00000043480 rbbp8 / F1R983 / retinoblastoma binding protein 8 / Q80YR6* / Q99708* / RB binding protein 8, endonuclease* / retinoblastoma binding protein 8, endonuclease*  / complex / reaction
 ENSDARG00000078759 dna2 / DNA replication helicase/nuclease 2 / P51530* / Q6ZQJ5* / DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2*  / complex / reaction
 ENSDARG00000040303 nbn / nibrin / Q5I2W8 / O60934* / Q9R207*  / complex / reaction
 ENSDARG00000038917 rad50 / RAD50 homolog, double strand break repair protein / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / reaction / complex
 ENSDARG00000098211 wrn / Werner syndrome / O09053* / Q14191* / Werner syndrome RecQ like helicase*  / reaction / complex
 ENSDARG00000052827 top3a / DNA topoisomerase III alpha / O70157* / Q13472* / topoisomerase (DNA) III alpha*  / reaction / complex






 

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