ENSGALG00000005279


Gallus gallus

Features
Gene ID: ENSGALG00000005279
  
Biological name :BRIP1
  
Synonyms : BRIP1 / Fanconi anemia group J protein homolog / Q3YK19
  
Possible biological names infered from orthology : BRCA1 interacting protein C-terminal helicase 1 / Q5SXJ3 / Q9BX63
  
Species: Gallus gallus
  
Chr. number: 19
Strand: 1
Band:
Gene start: 7494633
Gene end: 7541587
  
Corresponding Affymetrix probe sets: Gga.17801.1.S1_s_at (Chicken Array)   GgaAffx.26464.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000038436
NCBI entrez gene - 417642     See in Manteia.
RefSeq - XM_015295788
RefSeq - NM_001033058
RefSeq - XM_015295789
RefSeq Peptide - NP_001028230
swissprot - Q3YK19
Ensembl - ENSGALG00000005279
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 brip1ENSDARG00000074410Danio rerio
 BRIP1ENSG00000136492Homo sapiens
 Brip1ENSMUSG00000034329Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RTEL1* / Q0VGM9* / Q9NZ71* / RTEL1-TNFRSF6B* / RTEL1-TNFRSF6B readthrough (NMD candidate)* / regulator of telomere elongation helicase 1*ENSGALG0000000612321
DDX11* / Q6AXC6* / Q96FC9* / DEAD/H-box helicase 11* / Mus musculus DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 (Ddx11), transcript variant 2, mRNA.*ENSGALG000000396363


Protein motifs (from Interpro)
Interpro ID Name
 IPR006554  Helicase-like, DEXD box c2 type
 IPR006555  ATP-dependent helicase, C-terminal
 IPR010614  DEAD2
 IPR013020  ATP-dependent helicase Rad3/Chl1-like
 IPR014013  Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006139 nucleobase-containing compound metabolic process IEA
 biological_processGO:0006281 DNA repair TAS
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007129 synapsis IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007284 spermatogonial cell division IEA
 biological_processGO:0007286 spermatid development IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0010705 meiotic DNA double-strand break processing involved in reciprocal meiotic recombination IEA
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:0051026 chiasma assembly IEA
 biological_processGO:0072520 seminiferous tubule development IEA
 biological_processGO:1990918 double-strand break repair involved in meiotic recombination IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003678 DNA helicase activity TAS
 molecular_functionGO:0004003 ATP-dependent DNA helicase activity IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008026 ATP-dependent helicase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051539 4 iron, 4 sulfur cluster binding IEA


Pathways (from Reactome)
Pathway description
Fanconi Anemia Pathway in DNA repair
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000734 RPA2 / RPA4* / Q13156* / P15927* / replication protein A2* / replication protein A4*  / complex / reaction
 ENSGALG00000002663 ATR / ATR serine/threonine kinase / Q13535*  / complex / reaction
 ENSGALG00000003072 RPA1 / Q5ZJJ2 / Replication protein A 70 kDa DNA-binding subunit / Q8VEE4* / P27694* / replication protein A1*  / reaction / complex
 ENSGALG00000004037 DNA2 / Q5ZKG3 / DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2 / P51530* / Q6ZQJ5* / DNA replication helicase...  / complex / reaction
 ENSGALG00000005028 TOP3A / DNA topoisomerase 3-alpha isoform 1 / O70157* / Q13472* / DNA topoisomerase III alpha* / topoisomerase (DNA) III alpha*  / complex / reaction
 ENSGALG00000007155 RMI2 / Q5ZM20 / RecQ-mediated genome instability protein 2 / Q96E14* / Q3UPE3* / RecQ mediated genome instability 2*  / complex / reaction
 ENSGALG00000014982 RBBP8 / RB binding protein 8, endonuclease / Q80YR6* / Q99708* / retinoblastoma binding protein 8, endonuclease*  / complex / reaction
 ENSGALG00000010748 EXO1 / exonuclease 1 / Q9QZ11* / Q9UQ84*  / complex / reaction
 ENSGALG00000017159 ATM / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / complex / reaction
 ENSGALG00000010700 RPA3 / replication protein A3 / P35244* / Q9CQ71* / Replication protein A 14 kDa subunit *  / complex / reaction
 ENSGALG00000017211 MRE11 / double-strand break repair protein MRE11 / Mre11a* / Q61216* / P49959* / MRE11 homolog, double strand break repair nuclease*  / reaction / complex
 ENSGALG00000006794 RAD50* / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / complex / reaction
 ENSGALG00000040909 WRN / Werner syndrome RecQ like helicase / O09053* / Q14191*  / complex / reaction






 

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