ENSGALG00000006123


Gallus gallus

Features
Gene ID: ENSGALG00000006123
  
Biological name :
  
Synonyms :
  
Possible biological names infered from orthology : Q0VGM9 / Q9NZ71 / regulator of telomere elongation helicase 1 / RTEL1 / RTEL1-TNFRSF6B / RTEL1-TNFRSF6B readthrough (NMD candidate)
  
Species: Gallus gallus
  
Chr. number: 20
Strand: -1
Band:
Gene start: 9857387
Gene end: 9895824
  
Corresponding Affymetrix probe sets: Gga.12530.1.S1_s_at (Chicken Array)   Gga.18194.1.S1_at (Chicken Array)   Gga.18194.1.S1_s_at (Chicken Array)   GgaAffx.26754.1.S1_at (Chicken Array)   GgaAffx.26754.2.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000009867
Ensembl peptide - ENSGALP00000047807
Ensembl peptide - ENSGALP00000045608
NCBI entrez gene - 419262     See in Manteia.
RefSeq - XM_004947130
RefSeq - XM_004947133
RefSeq - XM_015296601
RefSeq - XM_417435
swissprot - A0A1D5NYZ7
swissprot - F1NE49
swissprot - A0A1D5P542
Ensembl - ENSGALG00000006123
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rtel1ENSDARG00000035074Danio rerio
 RTEL1ENSG00000258366Homo sapiens
 RTEL1-TNFRSF6BENSG00000026036Homo sapiens
 Rtel1ENSMUSG00000038685Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BRIP1 / Q3YK19 / Fanconi anemia group J protein homolog / Q5SXJ3* / Q9BX63* / BRCA1 interacting protein C-terminal helicase 1*ENSGALG0000000527920
DDX11* / Q6AXC6* / Q96FC9* / DEAD/H-box helicase 11* / Mus musculus DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 (Ddx11), transcript variant 2, mRNA.*ENSGALG000000396363


Protein motifs (from Interpro)
Interpro ID Name
 IPR006554  Helicase-like, DEXD box c2 type
 IPR006555  ATP-dependent helicase, C-terminal
 IPR010614  DEAD2
 IPR013020  ATP-dependent helicase Rad3/Chl1-like
 IPR014013  Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030845  Regulator of telomere elongation helicase 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000723 telomere maintenance IEA
 biological_processGO:0000732 strand displacement IEA
 biological_processGO:0006139 nucleobase-containing compound metabolic process IEA
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0010569 regulation of double-strand break repair via homologous recombination IEA
 biological_processGO:0031297 replication fork processing IEA
 biological_processGO:0032206 positive regulation of telomere maintenance IEA
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:0043247 telomere maintenance in response to DNA damage IEA
 biological_processGO:0045910 negative regulation of DNA recombination IEA
 biological_processGO:0090657 telomeric loop disassembly IEA
 biological_processGO:1902990 mitotic telomere maintenance via semi-conservative replication IEA
 biological_processGO:1904430 negative regulation of t-circle formation IEA
 biological_processGO:1904506 negative regulation of telomere maintenance in response to DNA damage IEA
 biological_processGO:1904535 positive regulation of telomeric loop disassembly IEA
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004003 ATP-dependent DNA helicase activity IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008026 ATP-dependent helicase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051539 4 iron, 4 sulfur cluster binding IEA
 molecular_functionGO:0070182 DNA polymerase binding IEA


Pathways (from Reactome)
Pathway description
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000040380 RAD51C / RAD51 paralog C / O43502* / Q924H5* / DNA repair 3 *  / reaction
 ENSGALG00000011533 XRCC3 / X-ray repair cross complementing 3 / O43542* / Q9CXE6* / X-ray repair complementing defective repair in Chinese hamster cells 3*  / reaction






 

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