ENSGALG00000014982


Gallus gallus

Features
Gene ID: ENSGALG00000014982
  
Biological name :RBBP8
  
Synonyms : RB binding protein 8, endonuclease / RBBP8
  
Possible biological names infered from orthology : Q80YR6 / Q99708 / retinoblastoma binding protein 8, endonuclease
  
Species: Gallus gallus
  
Chr. number: 2
Strand: 1
Band:
Gene start: 103124812
Gene end: 103156745
  
Corresponding Affymetrix probe sets: Gga.12526.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000024123
NCBI entrez gene - 421071     See in Manteia.
RefSeq - XM_004939772
RefSeq - XM_015277968
RefSeq - XM_015277969
RefSeq - XM_015277970
RefSeq - XM_015277971
RefSeq - XM_015277972
RefSeq - XM_015277973
RefSeq - XM_015277974
RefSeq - XM_419158
RefSeq - XM_004939771
swissprot - E1C2F1
Ensembl - ENSGALG00000014982
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rbbp8ENSDARG00000043480Danio rerio
 RBBP8ENSG00000101773Homo sapiens
 Rbbp8ENSMUSG00000041238Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RBBP8NL / RBBP8 N-terminal like / Q8NC74*ENSGALG0000004593814


Protein motifs (from Interpro)
Interpro ID Name
 IPR013882  DNA endonuclease Ctp1, C-terminal
 IPR019518  DNA endonuclease Ctp1, N-terminal
 IPR033316  DNA endonuclease RBBP8-like
 IPR033594  DNA endonuclease RBBP8


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IEA
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000724 double-strand break repair via homologous recombination IEA
 biological_processGO:0001835 blastocyst hatching IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006289 nucleotide-excision repair IEA
 biological_processGO:0010792 DNA double-strand break processing involved in repair via single-strand annealing IEA
 biological_processGO:0031572 G2 DNA damage checkpoint IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:1903507 negative regulation of nucleic acid-templated transcription IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0017053 transcriptional repressor complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000014 single-stranded DNA endodeoxyribonuclease activity IEA
 molecular_functionGO:0001103 RNA polymerase II repressing transcription factor binding IEA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
HDR through Single Strand Annealing (SSA)
HDR through MMEJ (alt-NHEJ)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000734 RPA2 / RPA4* / Q13156* / P15927* / replication protein A2* / replication protein A4*  / complex / reaction
 ENSGALG00000002288 LIG3 / DNA ligase 3 / P49916* / ligase III, DNA, ATP-dependent*  / complex
 ENSGALG00000002663 ATR / ATR serine/threonine kinase / Q13535*  / reaction / complex
 ENSGALG00000003072 RPA1 / Q5ZJJ2 / Replication protein A 70 kDa DNA-binding subunit / Q8VEE4* / P27694* / replication protein A1*  / complex / reaction
 ENSGALG00000004037 DNA2 / Q5ZKG3 / DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2 / P51530* / Q6ZQJ5* / DNA replication helicase...  / complex / reaction
 ENSGALG00000005028 TOP3A / DNA topoisomerase 3-alpha isoform 1 / O70157* / Q13472* / DNA topoisomerase III alpha* / topoisomerase (DNA) III alpha*  / complex / reaction
 ENSGALG00000007155 RMI2 / Q5ZM20 / RecQ-mediated genome instability protein 2 / Q96E14* / Q3UPE3* / RecQ mediated genome instability 2*  / complex / reaction
 ENSGALG00000040909 WRN / Werner syndrome RecQ like helicase / O09053* / Q14191*  / complex / reaction
 ENSGALG00000005279 BRIP1 / Q3YK19 / Fanconi anemia group J protein homolog / Q5SXJ3* / Q9BX63* / BRCA1 interacting protein C-terminal helicase 1*  / reaction / complex
 ENSGALG00000033781 FEN1 / Q5ZLN4 / Flap endonuclease 1 / P39748* / flap structure-specific endonuclease 1*  / complex / reaction
 ENSGALG00000017159 ATM / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / complex / reaction
 ENSGALG00000014982 RBBP8 / RB binding protein 8, endonuclease / Q80YR6* / Q99708* / retinoblastoma binding protein 8, endonuclease*  / complex
 ENSGALG00000017290 RAD51AP1 / RAD51 associated protein 1 / Q96B01* / RAD51-associated protein 1 isoform 2 *  / complex
 ENSGALG00000010748 EXO1 / exonuclease 1 / Q9QZ11* / Q9UQ84*  / complex / reaction
 ENSGALG00000017211 MRE11 / double-strand break repair protein MRE11 / Mre11a* / Q61216* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSGALG00000006794 RAD50* / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / complex / reaction
 ENSGALG00000010700 RPA3 / replication protein A3 / P35244* / Q9CQ71* / Replication protein A 14 kDa subunit *  / reaction / complex
 ENSGALG00000017073 BRCA2 / BRCA2, DNA repair associated / P51587* / P97929* / Breast cancer type 2 susceptibility protein homolog *  / complex
 ENSGALG00000009228 PARP1 / poly / P09874* / poly(ADP-ribose) polymerase 1* / poly (ADP-ribose) polymerase family, member 1*  / complex / reaction
 ENSGALG00000030313 RAD51 / P37383 / DNA repair protein RAD51 homolog 1 / Q08297* / Q06609* / AC012476.1* / DNA repair 1 * / RAD51 recombinase*  / complex






 

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