ENSGALG00000030313


Gallus gallus

Features
Gene ID: ENSGALG00000030313
  
Biological name :RAD51
  
Synonyms : DNA repair protein RAD51 homolog 1 / P37383 / RAD51
  
Possible biological names infered from orthology : AC012476.1 / DNA repair 1 / Q06609 / Q08297 / RAD51 recombinase
  
Species: Gallus gallus
  
Chr. number: 5
Strand: 1
Band:
Gene start: 907507
Gene end: 914989
  
Corresponding Affymetrix probe sets: Gga.16123.1.S1_at (Chicken Array)   Gga.2303.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000063189
Ensembl peptide - ENSGALP00000046453
NCBI entrez gene - 396086     See in Manteia.
RefSeq - XM_015286147
RefSeq - NM_205173
RefSeq - XM_015286146
RefSeq Peptide - NP_990504
swissprot - P37383
swissprot - A0A1L1RWH2
Ensembl - ENSGALG00000030313
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rad51ENSDARG00000041411Danio rerio
 AC012476.1ENSG00000285396Homo sapiens
 RAD51ENSG00000051180Homo sapiens
 Rad51ENSMUSG00000027323Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003593  AAA+ ATPase domain
 IPR010995  DNA repair Rad51/transcription factor NusA, alpha-helical
 IPR011941  DNA recombination/repair protein Rad51
 IPR013632  DNA recombination and repair protein Rad51-like, C-terminal
 IPR016467  DNA recombination and repair protein, RecA-like
 IPR020587  DNA recombination and repair protein RecA, monomer-monomer interface
 IPR020588  DNA recombination and repair protein RecA-like, ATP-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000722 telomere maintenance via recombination IEA
 biological_processGO:0000724 double-strand break repair via homologous recombination ISS
 biological_processGO:0000730 DNA recombinase assembly ISS
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0006259 DNA metabolic process IEA
 biological_processGO:0006268 DNA unwinding involved in DNA replication ISS
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006312 mitotic recombination IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISS
 biological_processGO:0007131 reciprocal meiotic recombination IBA
 biological_processGO:0010212 response to ionizing radiation IBA
 biological_processGO:0010833 telomere maintenance via telomere lengthening IEA
 biological_processGO:0031297 replication fork processing IEA
 biological_processGO:0032200 telomere organization IEA
 biological_processGO:0042148 strand invasion IBA
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0070192 chromosome organization involved in meiotic cell cycle IEA
 biological_processGO:0071312 cellular response to alkaloid IEA
 biological_processGO:0072711 cellular response to hydroxyurea IEA
 biological_processGO:1990414 replication-born double-strand break repair via sister chromatid exchange IEA
 biological_processGO:1990426 mitotic recombination-dependent replication fork processing IEA
 cellular_componentGO:0000228 nuclear chromosome ISS
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IEA
 cellular_componentGO:0000793 condensed chromosome IEA
 cellular_componentGO:0000794 condensed nuclear chromosome IEA
 cellular_componentGO:0000800 lateral element IEA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm IBA
 cellular_componentGO:0005737 cytoplasm ISS
 molecular_functionGO:0000150 recombinase activity IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000400 four-way junction DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding ISS
 molecular_functionGO:0003697 single-stranded DNA binding ISS
 molecular_functionGO:0004520 endodeoxyribonuclease activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008094 DNA-dependent ATPase activity IEA
 molecular_functionGO:0043142 single-stranded DNA-dependent ATPase activity ISS


Pathways (from Reactome)
Pathway description
Homologous DNA pairing and strand exchange
ATM mediated phosphorylation of repair proteins
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Presynaptic phase of homologous DNA pairing and strand exchange


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000017073 BRCA2 / BRCA2, DNA repair associated / P51587* / P97929* / Breast cancer type 2 susceptibility protein homolog *  / reaction / complex
 ENSGALG00000039171 RAD52 / DNA repair protein RAD52 homolog isoform 2 / P43351* / P43352* / RAD52 homolog, DNA repair protein*  / complex / reaction
 ENSGALG00000014982 RBBP8 / RB binding protein 8, endonuclease / Q80YR6* / Q99708* / retinoblastoma binding protein 8, endonuclease*  / complex
 ENSGALG00000030313 RAD51 / P37383 / DNA repair protein RAD51 homolog 1 / Q08297* / Q06609* / AC012476.1* / DNA repair 1 * / RAD51 recombinase*  / reaction / complex / -
 ENSGALG00000017290 RAD51AP1 / RAD51 associated protein 1 / Q96B01* / RAD51-associated protein 1 isoform 2 *  / complex
 ENSGALG00000042418 CHEK1 / Q8AYC9 / Serine/threonine-protein kinase Chk1 / O14757* / O35280* / checkpoint kinase 1*  / reaction






 

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