ENSDARG00000041411


Danio rerio

Features
Gene ID: ENSDARG00000041411
  
Biological name :rad51
  
Synonyms : rad51 / RAD51 recombinase
  
Possible biological names infered from orthology : AC012476.1 / DNA repair 1 / Q06609 / Q08297
  
Species: Danio rerio
  
Chr. number: 20
Strand: 1
Band:
Gene start: 46427963
Gene end: 46442137
  
Corresponding Affymetrix probe sets: Dr.1514.1.A1_at (Zebrafish Array)   Dr.1514.2.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000060705
Ensembl peptide - ENSDARP00000102254
Ensembl peptide - ENSDARP00000123382
NCBI entrez gene - 406487     See in Manteia.
swissprot - Q5TYR0
swissprot - Q5TYR1
swissprot - Q5TYR2
ZFIN ID - ZDB-GENE-040426-2286
Ensembl - ENSDARG00000041411
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RAD51ENSGALG00000030313Gallus gallus
 AC012476.1ENSG00000285396Homo sapiens
 RAD51ENSG00000051180Homo sapiens
 Rad51ENSMUSG00000027323Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003593  AAA+ ATPase domain
 IPR010995  DNA repair Rad51/transcription factor NusA, alpha-helical
 IPR011941  DNA recombination/repair protein Rad51
 IPR013632  DNA recombination and repair protein Rad51-like, C-terminal
 IPR016467  DNA recombination and repair protein, RecA-like
 IPR020587  DNA recombination and repair protein RecA, monomer-monomer interface
 IPR020588  DNA recombination and repair protein RecA-like, ATP-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR033925  Rad51/DMC1/RadA


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination IMP
 biological_processGO:0000730 DNA recombinase assembly IBA
 biological_processGO:0006259 DNA metabolic process IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006312 mitotic recombination IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007131 reciprocal meiotic recombination IBA
 biological_processGO:0010212 response to ionizing radiation IBA
 biological_processGO:0042148 strand invasion IBA
 biological_processGO:0046686 response to cadmium ion IEP
 biological_processGO:0051597 response to methylmercury IDA
 biological_processGO:0070192 chromosome organization involved in meiotic cell cycle IBA
 biological_processGO:1990426 mitotic recombination-dependent replication fork processing IEA
 cellular_componentGO:0000794 condensed nuclear chromosome IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IBA
 molecular_functionGO:0000150 recombinase activity IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000400 four-way junction DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IBA
 molecular_functionGO:0004520 endodeoxyribonuclease activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008094 DNA-dependent ATPase activity IBA


Pathways (from Reactome)
Pathway description
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Presynaptic phase of homologous DNA pairing and strand exchange


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000094 blood island blood island hematopoietic stem cell proliferation decreased rate , abnormal
blood island hepatoblast apoptotic process increased occurrence , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000242 male organism male organism male sterile , abnormal
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 ZFA:0000669 head kidney head kidney decreased size , abnormal
head kidney hematopoietic stem cell proliferation increased rate , abnormal
head kidney nucleate erythrocyte decreased amount , abnormal
head kidney thromboblast increased amount , abnormal
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 ZFA:0001094 whole organism whole organism chromosome damaged , abnormal
whole organism decreased length , abnormal
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 ZFA:0001114 head head decreased size , abnormal
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 ZFA:0009006 sperm sperm absent , abnormal
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 ZFA:0009014 hematopoietic stem cell hematopoietic stem cell decreased amount , abnormal
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 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte increased size , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000005274 rad52 / RAD52 homolog, DNA repair protein / P43351* / P43352*  / complex / reaction
 ENSDARG00000043480 rbbp8 / F1R983 / retinoblastoma binding protein 8 / Q80YR6* / Q99708* / RB binding protein 8, endonuclease* / retinoblastoma binding protein 8, endonuclease*  / complex
 ENSDARG00000041411 rad51 / RAD51 recombinase / Q06609* / Q08297* / AC012476.1* / DNA repair 1 *  / complex
 ENSDARG00000079015 brca2 / breast cancer 2, early onset / P97929* / P51587* / BRCA2, DNA repair associated* / Breast cancer type 2 susceptibility protein homolog *  / complex
 ENSDARG00000104765 chek1 / checkpoint kinase 1 / O14757* / O35280* / Serine/threonine-protein kinase Chk1 *  / reaction






 

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